A5041583426- Global Cancer Incidence and Screening
- Colorectal Cancer Screening and Detection
- Carcinogens and Genotoxicity Assessment
- Breast Cancer Treatment Studies
- Advanced MRI Techniques and Applications
- Cancer Risks and Factors
- BRCA gene mutations in cancer
- Economic and Financial Impacts of Cancer
- Prostate Cancer Treatment and Research
- Prostate Cancer Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- DNA Repair Mechanisms
- Scientific Computing and Data Management
- Ethics in Clinical Research
- NMR spectroscopy and applications
- Estrogen and related hormone effects
- Cervical Cancer and HPV Research
- Breast Lesions and Carcinomas
- Distributed and Parallel Computing Systems
- Molecular Biology Techniques and Applications
- Computational Physics and Python Applications
- RNA modifications and cancer
- Chemical Safety and Risk Management
- Molecular Junctions and Nanostructures
- Computational Drug Discovery Methods
University of Hong Kong
2023
Statistics Canada
2021-2023
Ontario Institute for Cancer Research
2012-2019
National Cancer Institute
2000-2015
University Health Network
2012-2014
Princess Margaret Cancer Centre
2012-2014
University of Toronto
2012-2014
National Institutes of Health
1987-2008
Markey Cancer Center
2007
University of California, San Francisco
1994-2004
Pharmacological inactivation of oncogenes is being investigated as a possible therapeutic strategy for cancer. One potential drawback that cessation such therapy may allow reactivation the oncogene and tumor regrowth. We used conditional transgenic mouse model MYC-induced tumorigenesis to demonstrate brief MYC results in sustained regression tumors differentiation osteogenic sarcoma cells into mature osteocytes. Subsequent did not restore cells' malignant properties but instead induced...
Background: Available cancer statistics pertain primarily to white and African American populations.This study describes racial or ethnic patterns of cancer-specific survival relative risks (RRs) death for all cancers combined the colon rectum, lung bronchus, prostate, female breast 6 major US groups.Methods: Cancer-specific rates were analyzed more than 1.78 million patients who resided in 9 SEER (Surveillance, Epidemiology, End Results) Program geographic areas diagnosed between 1975 1997...
We report cancer incidence, mortality, and stage distributions among Asians Pacific Islanders (API) residing in the U.S. note health disparities, using experience of non-Hispanic white population as referent group. New databases added to publicly available SEER*Stat software will enable public researchers further investigate patterns API groups.Cancer diagnoses groups occurring from 1 January 1998 31 December 2002 were included 14 Surveillance, Epidemiology, End Results (SEER) Program state...
BackgroundClinical prognostic groupings for localised prostate cancers are imprecise, with 30–50% of patients recurring after image-guided radiotherapy or radical prostatectomy. We aimed to test combined genomic and microenvironmental indices in cancer improve risk stratification complement clinical factors.MethodsWe used DNA-based alone combination intra-prostatic hypoxia measurements develop four 126 low-risk intermediate-risk (Toronto cohort) who will receive radiotherapy. validated these...
Abstract Motivation: The NanoString nCounter Platform is a new and promising technology for measuring nucleic acid abundances. It has several advantages over PCR-based techniques, including avoidance of amplification, direct sequence interrogation digital detection absolute quantification. These features minimize aspects experimental error hold promise dealing with challenging conditions such as archival formalin-fixed paraffin-embedded samples. However, systematic inter-sample technical...
The authors present a unique application of polyvinyl alcohol (PVA) cryogel as an anthropomorphic, elastic, vascular phantom material that can be used in MR imaging. composition consists two nontoxic ingredients: water and PVA. biomechanical properties adjusted to similar those excised porcine aortas by varying the number freeze-thaw cycles which PVA solution is exposed. T1, T2, shrinkage, tensile tubes function cycles. images dual elastic aortic undergoing pulsatile motion are shown.
The interpretation of chronic bioassay tests for carcinogenicity requires that the data be appropriately recorded. A “case history” each animal links pathology organ to length its life. This information can used in tumor incidence light survival information. role historical controls was discussed, and use significance a multidisciplinary approach assessment pattern response suggested. Multiple comparison methods valid continuous (or measurement) do not apply discrete analyses these studies....
Neoplastic and nonneoplastic lesions in untreated (C57BL/6N x C3H/HeN)F1 (B6C3F1) mice used as controls carcinogenesis tests were tabulated evaluated. The most common neoplasms 2,543 male hepatocellular adenomas carcinomas. In 2,522 female mice, tumors lymphomas, leukemias, pulmonary carcinomas, pituitary adenomas. risk of developing increased with the age mouse. Hepatocellular carcinomas metastasized 12% animals these tumors. Other than lymphomas few other metastasized. Nonneoplastic...
Fas, a member of the tumor necrosis factor receptor family, can induce apoptosis when activated by Fas ligand binding or anti-Fas antibody crosslinking. Genetic studies have shown that defect in Fas-mediated resulted abnormal development and function immune system mice. A point mutation cytoplasmic domain (a single base change from T to at 786), replacing isoleucine with asparagine, abolishes signal transducing property Fas. Mice homozygous for this mutant allele (lprcg/lprcg mice) develop...
Abstract BACKGROUND Prostate cancer mortality rates in the United States declined sharply after 1991 white men and 1992 black men. The current study was conducted to investigate possible mechanisms for declining prostate States. METHODS authors examined compared patterns of incidence, survival rates, among using 1969–1999 U.S. 1975–1999 survival, incidence‐based from Surveillance, Epidemiology, End Results (SEER) Program population. SEER data represent approximately 10% RESULTS incidence...
Variability in the incidence rates of some common naturally occurring tumors for 72 inbred F344 rat and 54 (C57BL/6N × C3H/HeN)F1 (B6C3F1) mouse control groups used carcinogenesis bioassays was evaluated. Significant heterogeneity observed at least two six laboratories lymphomas-leukemias, liver tumors, pituitary male endometrial stromal polyps female rat. interlaboratory several tumor types In contrast, lung lymphomas-leukemias B6C3F1 mice were relatively homogeneous within four five...
Most proteins destined for the extracellular space require disulfide bonds folding and stability. Disulfide are introduced co- post-translationally in endoplasmic reticulum (ER) cargo a redox relay that requires terminal electron acceptor. Oxygen can serve as acceptor vitro, but its role vivo remains unknown. Hypoxia causes ER stress, suggesting oxygen protein folding. Here we demonstrate existence of two phases bond formation living mammalian cells, with differential requirements oxygen....
We introduce BPG, a framework for generating publication-quality, highly-customizable plots in the R statistical environment. This open-source package includes multiple methods of displaying high-dimensional datasets and facilitates generation complex multi-panel figures, making it suitable datasets. A web-based interactive tool allows online figure customization, from which code can be downloaded integration with computational pipelines. BPG provides new approach linking scripted data...
Inflammatory breast carcinoma (IBC) and noninflammatory locally advanced (LABC) are both associated with poor prognosis; however, whether they distinct clinicopathologic entities remains controversial.To determine IBC LABC were different, we compared tumor characteristics, prognosis, age-specific incidence rate patterns in the Surveillance, Epidemiology, End-Results program. An age of 50 years served as a surrogate marker for menopause.Younger at diagnosis, poorer grade, negative estrogen...
Black females have lower breast carcinoma survival rates compared with white females. One possible reason is that black more advanced-stage disease. Another factor may be racial differences in the utilization of cancer treatments.The authors determined 6-year stage specific rates, adjusting for age and treatments (using estrogen receptor [ER] status), to determine whether there were treatment. Racial distributions disease used examine impact factors on diagnosis.For all cases, general,...
Hormone receptor expression (presence-positive or absence-negative) may reflect different stages of one disease breast cancer types. Determining whether hormone represents more phenotypes would have important paradigmatic and practical implications.Breast records were obtained from the National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) database. The study included 19,541 non-Hispanic white women with node-negative cancer. Standard tumor cell characteristics...
The age-specific incidence rate curve for breast carcinoma overall increases rapidly until age 50 years, and then continues to increase at a slower older women. In this analysis, our objective was compare patterns different morphologic types of carcinoma.We analyzed curves by histopathologic subclassification using records from 11 standard National Cancer Institute's Surveillance, Epidemiology, End Results (SEER) registries, diagnosed during the years 1992 1999. Data were examined <50 > or...