A5033042913- Lung Cancer Treatments and Mutations
- RNA modifications and cancer
- Lung Cancer Diagnosis and Treatment
- Gene expression and cancer classification
- Cancer Genomics and Diagnostics
- Chronic Disease Management Strategies
- Healthcare Policy and Management
- Radiomics and Machine Learning in Medical Imaging
- Bioinformatics and Genomic Networks
- Scientific Computing and Data Management
- Healthcare Operations and Scheduling Optimization
- Emergency and Acute Care Studies
- Distributed and Parallel Computing Systems
- Health disparities and outcomes
- Prostate Cancer Treatment and Research
- Computational Physics and Python Applications
- Cancer-related molecular mechanisms research
- Healthcare Systems and Reforms
- Molecular Biology Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Patient Satisfaction in Healthcare
- Mental Health and Patient Involvement
- Data Visualization and Analytics
- Patient-Provider Communication in Healthcare
- Health Systems, Economic Evaluations, Quality of Life
Institute for Clinical Evaluative Sciences
2021-2025
SingHealth
2017-2024
McMaster University
2020-2022
University of Ottawa
2022
SingHealth Duke-NUS Academic Medical Centre
2021-2022
Louisiana State University
2022
Louisiana State University Health Sciences Center New Orleans
2022
Duke-NUS Medical School
2021
Bayer (United States)
2020
Erasmus MC
2020
We introduce BPG, a framework for generating publication-quality, highly-customizable plots in the R statistical environment. This open-source package includes multiple methods of displaying high-dimensional datasets and facilitates generation complex multi-panel figures, making it suitable datasets. A web-based interactive tool allows online figure customization, from which code can be downloaded integration with computational pipelines. BPG provides new approach linking scripted data...
Background Older adults living in social housing report poor health and access to healthcare services. This study aimed estimate the prevalence of chronic diseases, influenza vaccination cancer screenings among residents versus non-residents Ontario, Canada. Methods We conducted a population-based cohort for all health-insured Ontarians alive aged 40 or older as 1 January 2020. Social were identified using postal codes. Validated administrative data case definitions used identify individuals...
Identification of genes that are upregulated during mammary epithelial cell morphogenesis may reveal novel regulators tumorigenesis. We have demonstrated gene expression programs in cells grown monolayer cultures differ significantly from those three-dimensional (3D) cultures. identify a protein tyrosine phosphate, PTPRO, was mature MCF-10A 3D structures but had low to undetectable levels Downregulation PTPRO by RNA interference inhibited proliferation arrest morphogenesis. Low correlated...
Tumour samples containing distinct sub-populations of cancer and normal cells present challenges in the development reproducible biomarkers, as these biomarkers are based on bulk signals from mixed tumour profiles. ISOpure is only mRNA computational purification method to date that does not require a paired tumour-normal sample, provides personalized profile for each patient, has been tested clinical data. Replacing profiles with ISOpure-preprocessed led better prognostic gene signatures...
Biomarkers lie at the heart of precision medicine. Surprisingly, while rapid genomic profiling is becoming ubiquitous, development biomarkers usually involves application bespoke techniques that cannot be directly applied to other datasets. There an urgent need for a systematic methodology create biologically-interpretable molecular models robustly predict key phenotypes. Here we present SIMMS (Subnetwork Integration Multi-Modal Signatures): algorithm fragments pathways into functional...
To explore the handling of psychiatric patients in medical hospitals and emergency departments (EDs) as well hospital characteristics associated with availability services these settings.From October 1, 2017, to April 2018, a telephone survey regarding presence nature was attempted among all US registered Medicare hospitals.Of included 4812 hospitals, 2394 (50%) were surveyed. Of 1108 (46%) have some available, either EDs or through consultation on general inpatient wards. If ED active...
Abstract Background Patients with chronic kidney disease (CKD) are at high risk of end-stage (ESKD). The Kidney Failure Risk Equation (KFRE), which predicts ESKD among patients CKD, has not been validated in primary care clinics Southeast Asia (SEA). Therefore, we aimed to (1) evaluate the performance existing KFRE equations, (2) recalibrate for better predictive precision, and (3) identify optimally feasible thresholds nephrologist referral dialysis planning SEA. Methods All CKD visiting...
Background The COVID-19 pandemic has had a major impact on health systems globally. sufficiency of hospitals' bed resource is cornerstone for access to care which can significantly the public outcomes. Objective We describe development dynamic simulation framework support agile planning during in Singapore. Materials and Methods study data were derived from Singapore General Hospital domain sources over period 1 January 2020 till 31 May covering when initial outbreak surge cases happened....
Previously we demonstrated that an mRNA signature reflecting cellular proliferation had strong prognostic value. As clinical applicability of signatures can be controversial, sought to improve our marker’s utility by validating its biological relevance, reproducibility in independent data sets and using technique. To facilitate evaluation with quantitative PCR (qPCR) a novel computational procedure was used reduce the number genes without significant information loss. These were validated...
Abstract We introduce BPG, an easy-to-use framework for generating publication-quality, highly-customizable plots in the R statistical environment. This open-source package includes novel methods of displaying high-dimensional datasets and facilitates generation complex multi-panel figures, making it ideal datasets. A web-based interactive tool allows online figure customization, from which code can be downloaded seamless integration with computational pipelines. BPG is available at...
While the dysregulation of specific pathways in cancer influences both treatment response and outcome, few current prognostic markers explicitly consider differential pathway activation. Here we explore this concept, focusing on K-Ras mutations lung adenocarcinoma (present 25%-35% patients).The effect mutation status accuracy existing signatures was evaluated 404 patients. Genes associated with were identified used to create a RAS activation classifier provide more accurate measure status....
<b><i>Background:</i></b> Chronic kidney disease (CKD) is a major global public health challenge. We investigated determinants of CKD and their clinical utility in an ethnically diverse Southeast Asian population. <b><i>Methods:</i></b> Electronic records (EHR) adults ≥40 years who visited any one 4 government polyclinics Singapore from January 1, 2012 to December 31, 2015 were analyzed. was defined as estimated glomerular filtration rate...
Jansen, Luc A.W. MSc; Ellison, Ashley E. MD; Nguyen, Francis DO; Martina, Andrew Spencer, Jordan M. Specker, Amy BA; Wierdsma, André I. PhD; Kathol, Roger G. van Schijndel, Maarten A. MD, MSc Author Information
Here we show real-time multiple gas identification on a mobile platform through the use of an array nanomechanical membrane-type surface stress sensors (MSS). Commercially available hardware is used to integrate MSS into portable unit with wireless capability. This transmits data consumer tablet where displayed and processed in real-time. To achieve processing limited computational power commercial hardware, machine learning algorithm known as Random Forest implemented. We demonstrate...
The opioid crisis remains a major public health concern. In ambulatory surgery, persistent postoperative use is poorly described and temporal trends are unknown. A population-based retrospective cohort study was undertaken in Ontario, Canada using routinely collected administrative data for adults undergoing surgery between 1 January 2013 31 December 2017. primary outcome use, defined best-practice methods. Multivariable generalised linear models were used to estimate the association of with...
<h3>Importance</h3> Data on the long-term health care expenditures associated with bariatric surgery consisting of Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy are lacking. <h3>Objective</h3> To compare 4-year after RYGB vs gastrectomy, identify factors independently expenditures, procedures in terms subsequent hospitalizations, procedures, all-cause mortality. <h3>Design, Setting, Participants</h3> In this propensity score–matched cohort study, all residents Ontario, Canada, who...
Managing bed utilization by ensuring the supply keeps up with demand is not an easy task in a large public hospital many medical disciplines. The managers who make decisions on reserving and allocating beds centrally require high-dimensional data from several information systems supporting processes emergency room, specialized clinics wards. In this work, we put together automated process for cleaning, consolidating integrating into reports required to analyse occupancy situations across...