Diabetic nephropathy (DN) is the single largest cause of end-stage renal disease (ESRD). Inflammation reaction mediated by NLRP3 inflammasome and Nrf2-related oxidative stress have been considered to play a very important role in progress diabetic (DN). Effective drugs for treatment still need be explored. Chlorogenic acid (CGA) kind polyphenol with Nrf2 activation property widely existed nature. The aims this study were evaluate renoprotective effect CGA elucidate anti-inflammation...

The most important control parameters in the methanol distillation process, which are directly related to product quality and yield, temperature, pressure water content of finished at top column. In order adapt development trend modern industrial technology be more accurate, faster stable, fusion multi-sensor data puts forward higher requirements. Traditional methods, such as PID fuzzy control, have disadvantages low heterogeneous processing capability, poor response speed accuracy when...

Background: RAC1 is involved in the progression of HCC as a regulator, but its prognostic performance and imbalance immune cell infiltration mediated by it are still unclear. We aim to explore properties HCC. Methods: separately downloaded data related from Cancer Genome Atlas (TCGA) GEO database. CIBERSORT deconvolution algorithm, weighted gene co-expression network analysis (WGCNA) LASSO algorithm participate identifying IRGs construction signatures. Results: The study discovered that...

Human immunodeficiency virus (HIV)–positive cases have been reported among people who injected drugs in Liangshan Prefecture southwest of China since 1995 and has become one the most seriously affected epidemic areas China. In 2004, several patients with HIV/acquired syndrome (AIDS) initiated antiretroviral treatment (ART) at Central Hospital Prefecture. From 2005 to 2013, number receiving ART dramatically increased. We conducted a retrospective cohort study analyze long-term survival time...

Previous studies have shown inconsistent or even contradictory results for some risk factors associated with HIV infection among drug users, and these may be partially explained by geographical variations.Data were collected from 11 methadone clinics in the Liangshan Yi Autonomous Prefecture 2004 to 2012. A non-spatial logistical regression model a geographically weighted logistic fitted analyze association between specific at individual level.This study enrolled 6,458 patients. The...

This study describes the current situation and projects dynamic trends for HIV prevalence in a highly endemic area of China, Liangshan Prefecture, Sichuan Province. Epidemiological, behavioral, population census data from multiple sources were analyzed to extract input an Asian Epidemic Model (AEM). Fitting curves historical used as baseline, future intervention scenarios explored using AEM. For 2007, modeled suggested ≉0.5% adult Liangshan, with estimated 17,450 people living HIV/AIDS 3,400...

Yi people make up about 50% of the population in Liangshan Prefecture, Sichuan Province, China, but accounted for 88.07% new HIV cases prefecture from 2011 to 2013. This study evaluated prevalence pregnant women Prefecture using sentinel surveillance (HSS) data over period 2009 2015.Xichang, Zhaojue County, and Butuo County were selected as HSS sites. We investigated temporal trends these areas, association between demographic behavioral characteristics risk infection.Data on a total 2797...

HIV-, HCV- and HIV/HCV co-infections among drug users have become a rapidly emerging global public health problem. In order to constrain the dual epidemics of HIV/AIDS use, China has adopted methadone maintenance treatment program (MMTP) since 2004. Studies geographic heterogeneity HIV HCV infections at local scale are sparse, which critical implications for future MMTP implementation policies covering both prevention in China. This study aimed characterize patterns prevalence township level...

Fused filament fabrication (FFF) additive manufacturing technology has the advantages of being low cost, having a simple operation, using wide types molding materials, and producing less pollution during printing process. However, mechanical properties molded sample are unsatisfactory due to limited bonding force between filaments forming process, which limits its further development application in engineering field. Herein, hybrid for heterogeneous materials based on ultrasonic-assisted...

With the continuous development of economy and society, power demand forecasting has become an important task industry. Accurate can promote operation supply However, since consumption is affected by a number factors, it difficult to accurately predict data. accumulation data in industry, machine learning technology shown great potential forecasting. In this study, gradient boosting decision tree (GBDT), extreme (XGBoost) light (LightGBM) are integrated stacking build XLG-LR fusion model...

Diabetes and thyroid dysfunction are two closely related endocrine diseases. Increasing evidences show that gut microbiota plays an important role in both glucose metabolism homeostasis. Meanwhile, copy number variation (CNV) of host salivary α-amylase gene (AMY1) has been shown to correlate with Hence, we aim characterize the CNV AMY1 type 2 diabetes (T2D) patients or without subclinical hypothyroidism (SCH).High-throughput sequencing was used analyze euthyroid T2D patients, SCH healthy...

This paper aimed to analyze the situation of HIV infection in Liangshan Yi Autonomous, including recent rate and ongoing strategies on prevention disease this prefecture.Surveillance data population size, medical institutions, from 2011 2013 prefecture was collected. The total numbers people living areas appeared as 412 608, 393 699 443 025 above mentioned three years. overall with HIV/AIDS were 4 480, 3 999 719 respectively years observation, using ELISA WB blot. We also used ELISA, Western...

Background The human immunodeficiency virus (HIV) and hepatitis C (HCV) are major public health problems. Many studies have been performed to investigate the association between demographic behavioral factors HIV or HCV infection. However, some of results these in conflict. Methodology/Principal Findings data all entrants 11 national methadone clinics Yi Autonomous Prefecture from March 2004 December 2012 were collected database. Several spatial regression models used analyze specific...

As a response to severe HIV epidemic in the Liangshan Prefecture, one of worst China, population based interventions, including two population-wide screening, have been carried out since 2005 at townships remote mountainous region Liangshan. The objective our mathematical modeling study is assess temporal dynamics on data collected area during period 2005-2010.A model was set up describe transmission area. calibrated by fitting it testing and treatment from 2008. Validation done comparing...

We aimed to evaluate HIV prevalence among residents of Liangshan Prefecture through sentinel surveillance (HSS) data over the period from 2010 2016, and investigate risk factors for infection in this population interactions them. Two sites (Dechang Ningnan counties) with majority-Han populations, 1 site (Butuo) a majority-Yi were selected. used questionnaires residents’ demographic behavioral characteristics performed testing. Multivariate logistic regression path analysis undertaken...

We aimed to analyze factors related human immunodeficiency virus (HIV) infection among 15 25-year-old rural unmarried Yi adolescents in Liangshan Autonomous Prefecture from 2011 2016, and investigate the relationship HIV-related risk factors.Three sites (Butuo, Zhaojue, Ganluo counties) with a population were selected 2016 prefecture. used questionnaires demographic behavioral characteristics performed HIV testing. Logistic regression analysis multiple correspondence (MCA) data.A total of...

Chronic hepatitis B (CHB) is a major global health burden. Liver fibrosis, an insidious process, the main histopathological change in CHB that might lead to end-stage liver disease if left untreated. The intermediate fibrosis (S2) optimal time start antiviral therapy. aim of present study was examine proteomic changes patients with at different fibrotic stages, view identify future serum biomarkers for S2. Ninety were grouped into mild (S0-1), (S2), and severe (S3-4) (61 men 29 women; age...

We evaluated HIV prevalence among unmarried youth in rural areas of Liangshan Prefecture southwest China over the period 2011–2015, and interactions between behaviors associated with risk. used sentinel surveillance (HSS) data for our analysis. questionnaires to investigate information aged 15 25 years performed testing. Multivariate logistic regression path analysis were applied explore associations behavioral factors related infection. A total 9536 enrolled this study, whom 2.75%...

Objective: To analyze the HIV-infection related behaviors among unmarried youths in rural areas of Liangshan prefecture from 2011 to 2013 and factors that influencing HIV transmission population under research. Methods: According sentinel surveillance methods for data collection, EpiData 3.1 SPSS 19.0 were used handle both Chi-square test logistic regression explore factors. Results: A total number 5 871 qualified involved this study with prevalence rate on infection those as 3.45% (201/5...

We propose a polarization-insensitive space-division multiplexing scheme with self-heterodyne detection by simplified one balanced photodiode receiver based on optical frequency comb. A 17×200-Gb/s 16QAM transmission over 1-km 19-core fiber using low-cost DFB laser is demonstrated.