A5103071034- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Circular RNAs in diseases
- Drug Transport and Resistance Mechanisms
- Protein Interaction Studies and Fluorescence Analysis
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Metabolomics and Mass Spectrometry Studies
- Wnt/β-catenin signaling in development and cancer
- Natural product bioactivities and synthesis
- Renal cell carcinoma treatment
- RNA Research and Splicing
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Cholangiocarcinoma and Gallbladder Cancer Studies
- MRI in cancer diagnosis
- Immune cells in cancer
- Fibroblast Growth Factor Research
- Single-cell and spatial transcriptomics
- Cancer-related gene regulation
- Dermatology and Skin Diseases
- Cell Adhesion Molecules Research
- Surgical Sutures and Adhesives
Hubei University of Chinese Medicine
2024
Nanjing Medical University
2024
Jiangsu Province Hospital
2024
Sun Yat-sen University
2014-2023
Liaoning University
2021-2023
Third Affiliated Hospital of Sun Yat-sen University
2020-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Peking University
2023
Peking University Third Hospital
2023
Beijing National Laboratory for Molecular Sciences
2023
Abstract The Warburg effect is an important characteristic of tumor cells, making it attractive therapeutic target. Current anticancer drug development strategies predominantly focus on inhibitors the specific molecular effectors involved in cell proliferation. These drugs or natural compounds, many which target and underlying mechanisms, still need to be characterized. To elucidate effects a diterpenoid, oridonin, we first demonstrated activity oridonin both vitro vivo colorectal cancer...
Abstract Clinical and experimental evidence indicates that macrophages could promote solid-tumor progression metastasis. However, the mechanisms underlying this process remain unclear. Here we show yes-associated protein 1 (YAP1), a transcriptional regulator controls tissue growth regeneration, has an important role in tumor necrosis factor α (TNF α)-induced breast cancer migration. Mechanistically, macrophage conditioned medium (CM) or TNFα triggers IκB kinases (IKKs)-mediated YAP...
Polypeptides encoded by long noncoding RNAs (lncRNAs) are a novel class of functional molecules. However, whether these hidden polypeptides participate in the TP53 pathway and play significant biological role is still unclear. Here, we discover that TP53-regulated lncRNAs can encode peptides, two which various human cell lines. Using ribosome profiling RNA-seq approaches HepG2 cells, systematically identified more than 300 further confirmed 15 peptides. Furthermore, several peptides were...
Glioma is an intracranial malignant tumor and remains largely incurable. Circular RNAs are prominent modulators in glioma progression. This study investigated the function of circular RNA DLC1 (circDLC1) proliferation cells. circDLC1 expression tissues cells was determined using RT-qPCR. The effect on analyzed CCK-8, colony formation, EdU staining assays. METTL3, miR-671-5p, CTNNBIP1 expressions were determined. N6 methyladenosine (m6A) level MeRIP. binding relationship between miR-671-5p or...
Disrupted mitochondrial dynamics and mitophagy contribute to functional deterioration of skeletal muscle (SM) during aging, but the regulatory mechanisms are poorly understood. Our previous study demonstrated that expression thyroid hormone receptor α (TRα) decreased significantly in aged mice, suggesting alteration thyroidal elements, especially TRα, might attenuate local THs action thus cause degeneration SM with while underlying mechanism remains be further explored. In this study,...
Significance Small RNAs (sRNAs) are most important regulators in eukaryotes. Although different kinds of sRNAs have been extensively studied higher eukaryotes, their role remains largely unknown protozoa. We systematically investigated the full genome Giardia lamblia , primitive eukaryote known. Surprisingly, we found that two major types (i.e., endogenous siRNAs and tRNA-derived sRNAs) encoded G. whereas canonical microRNAs could not be identified this parasite. Additional studies showed...
The aberrant expression of long non‑coding RNAs is closely associated with drug resistance in multiple types cancer. Long intergenic RNA 00707 (LINC00707) has previously been reported to be an oncogene able promote lung adenocarcinoma cell proliferation and metastasis. However, its role the progression cisplatin (DDP) non‑small‑cell cancer (NSCLC) requires further elucidation. In present study, LINC00707 microRNA (miR)‑145 levels were measured using reverse transcription‑quantitative PCR...
Secreted frizzled-related protein 2 (SFRP2) is a glycoprotein with frizzled-like cysteine-rich domain that binds Wnt ligands or frizzled receptors to regulate signaling. SFRP2 frequently hypermethylated in glioma patients, and analysis of TCGA data indicates one the most downregulated genes radiotherapy treated patients. In present study, we aimed explore potential function tumorigenesis radioresistance glioma. The RNA sequencing samples were downloaded analyzed. expression 166 patients was...
Abstract Background Hepatocellular carcinoma (HCC) is a common cancer and the leading cause persistent hepatitis B virus (HBV) infection. We aimed to identify some core genes pathways for HBV-related HCC. Methods Gene expression profiles of GSE62232, GSE121248, GSE94660 were available from Expression Omnibus (GEO). The GSE62232 GSE121248 analysis datasets was validation dataset. GEO2R online tool Venn diagram software applied analyze commonly differentially expressed between HCC tissues...
Vulnerable atherosclerotic plaque rupture is the principal mechanism that accounts for myocardial infarction and stroke. High matrix metalloproteinase-9 (MMP-9) expression activity have been proven to lead instability. Metformin, a first-line treatment type 2 diabetes, beneficial vulnerability. However, underlying its anti-atherogenic effect remains unclear. Molecular docking surface plasmon resonance experiments showed metformin directly interacts with MMP-9, incubated MMP-9 overexpressing...
We hypothesized that specific amino acids or acylcarnitines would have benefits for the differential diagnosis of diabetes. Thus, a targeted metabolomics and in patients with diabetes its complications was carried out.A cohort 54 normal individuals 156 type 2 mellitus and/or diabetic enrolled from First Affiliated Hospital Jinzhou Medical University studied. The subjects were divided into five main groups: individuals, impaired fasting glucose, overt diabetes, microvascular complications,...
Objectives The small noncoding RNAs (sncRNAs) including microRNAs and the noncanonical sncRNAs [i.e., tRNA-derived (tsRNAs) rRNA-derived (rsRNAs)] are a vital class of gene regulators in response to variety diseases. We focus on an sncRNA signature enriched hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF) develop plasma exosome-based noninvasive biomarker for human ACLF. Methods In this work, related HBV-ACLF were identified by RNA sequencing (RNA-seq) exosomes collected...
Background: Patients with chronic hepatitis B (CHB) severe acute exacerbation (SAE) are at a progression stage of acute-on-chronic liver failure (ACLF) but uniform models for predicting ACLF occurrence lacking. We aimed to present risk prediction model early identify the patients high and predict survival patient. Methods: selected best variable combination using novel recursive feature elimination algorithm develop validate classification regression also an online application on cloud...
Ratio of carbohydrate antigen 19-9 level to total bilirubin (CA19-9/TB) is used reduce the influence obstructive jaundice on concentration CA19-9, thereby determining correlation between CA19-9/TB and tumor recurrence or long-term prognosis patients with pancreatic head cancer (PHC).In this study, a 339 were enrolled. The optimal cut-off value was determined by ROC curve based preoperative 1-year survival, divided into low-ratio group (Group 1) high-ratio 2) accordingly. Univariate...
The liver is the largest glandular organ in body and has a unique distribution of cells biomolecules. However, treatment outcome end-stage disease extremely poor. Single-cell sequencing new advanced powerful technique for identifying rare cell populations biomolecules by analyzing characteristics gene expression between individual cells. These might be used as potential targets immunotherapy diseases contribute to development precise individualized treatment. Compared whole-tissue RNA...
Objective: To study the segment of liver according to large amount three-dimensional(3D) reconstructive images normal human livers and vascular system, recognize basic functional unit based on anatomic features intrahepatic portal veins. Methods: The enhanced CT primitive DICOM files 1 260 from different age groups who treated October 2013 February 2017 provided by 16 hospitals were analyzed using computer-aided surgery system.The 3D system reconstructed, digital model was established.The...