A5090774757- Acute Myeloid Leukemia Research
- Synthesis and Characterization of Heterocyclic Compounds
- Synthesis and Biological Evaluation
- Lymphoma Diagnosis and Treatment
- Synthesis and pharmacology of benzodiazepine derivatives
- Synthesis and Reactivity of Heterocycles
- Phenothiazines and Benzothiazines Synthesis and Activities
- Breast Cancer Treatment Studies
- Neuroscience and Neuropharmacology Research
- Chronic Lymphocytic Leukemia Research
- Thyroid Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Medical and Biological Ozone Research
- Quinazolinone synthesis and applications
- Organic Chemistry Cycloaddition Reactions
- Liver Disease and Transplantation
- Hematopoietic Stem Cell Transplantation
- Tracheal and airway disorders
- Chronic Myeloid Leukemia Treatments
- COVID-19 and healthcare impacts
- Male Breast Health Studies
- Chemical synthesis and pharmacological studies
- Telomeres, Telomerase, and Senescence
- Breast Lesions and Carcinomas
- Reconstructive Surgery and Microvascular Techniques
Ospedale Vincenzo Cervello
2011-2025
Agostino Gemelli University Polyclinic
2009-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2024-2025
Università Cattolica del Sacro Cuore
2006-2015
University of Sassari
1988-1997
University of Genoa
1989
Aims : The histological diagnosis is critical for the postsurgical management and follow‐up of thyroid malignancies. differential between papillary carcinoma hyperfunctioning lesions, either with hyperplasia or a follicular architecture, can create real diagnostic difficulty. aim this study was to evaluate expression several antibodies considered be markers malignancy in malignant neoplasms include most effective them panel. Methods results One hundred resected nodules—58 benign lesions 42...
Mesenchymal tumors of the breast represent a rare and diverse group neoplasms, accounting for 0.5% all tumors. These originate from mesenchymal tissues encompass variety histological subtypes. Malignant are particularly aggressive, characterized by high propensity local recurrence an overall poor prognosis. The rarity these cases has hindered development robust clinical studies, resulting in lack standardized diagnostic treatment guidelines considerable variability management. This review...
Abstract Background The addition of a FLT3 inhibitor (FLT3i) to standard chemotherapy treat fit newly diagnosed (ND) patients with ‐mutated acute myeloid leukemia (AML) represents the care resulting from clinical trial results. However, evidence regarding FLT3i adoption in routine practice is still scarce. Methods Clinical data are reported 394 ND AML enrolled retrospective observational Italian Cohort Study on and treated an upfront intensive regimen (FLT3i group, n = 92) or without (CT...
Mesenchymal tumors of the breast constitute a rare and heterogeneous group neoplasms, representing only 0.5% to 1% all tumors. Originating from mesenchymal tissues, these include various histological subtypes. They are particularly aggressive, characterized by high propensity for local recurrence an overall poor prognosis. The rarity cases has impeded development comprehensive clinical studies, leading lack standardized diagnostic protocols treatment guidelines. This review provides thorough...
To evaluate the efficacy of thyroid fine needle aspiration cytology (FNAC) processed by liquid-based (LBC) as compared to conventional smears (CS) in 10,360 consecutive cases 3 reference periods.In 1997-1998, 2,394 FNACs had CS; 2001-2002, 3,463 both CS and LBC; 2004-2005, 4,503 only LBC. Three arbitrary parameters were chosen compare two different methods: rate inadequacy (IR), indeterminacy (INDR) malignancy (MR). In same biennia 6,184 thyroidectomy specimens examined.IR was, respectively,...
Transbronchial needle aspiration (TBNA) is recognized as a valuable tool for the sampling of mediastinal lymph nodes. In this study, we report data about diagnostic yield conventional TBNA in diagnosis and staging lung cancer.All patients with suspected cancer who underwent bronchoscopy years 2008 to 2012 were evaluated. was performed on nodes enlarged at chest computed tomography scan and/or increased fluorodeoxyglucose uptake positron emission tomography/computed scan. Cytologic results...
Abstract Background Pathologic complete response (pCR) after neoadjuvant treatment (NAD) is a strong prognostic biomarker associated with improved survival in breast cancer patients, especially HER2-positive and Triple negative subtypes. PIK3CA mutated up to 20% of HER2 positive cancers, contributes anti-HER-2 resistance may be predictive the lack anti NAD. mutations occur primarily at hotspots E545K exon 9 H1047R 20. Next generation sequencing has our knowledge regarding biology mechanisms...
The currently adopted prognostic factors for ILC are usually borrowed from the ductal histotype, despite differences in terms of clinico-pathological features and outcome. Thus, aim this analysis was to more precisely stratify prognosis undergone (neo)adjuvant therapy, explore addition chemotherapy (CT) endocrine therapy (ET) adjuvant setting. Clinico-pathological data consecutive patients (pts) affected by pure luminal/HER2-negative (stage I-III), surgery, were collected into 2 cohorts...
Introduction Acute myeloid leukemia (AML) relapse is the main cause of death after allogeneic stem cell transplant (allo-SCT). In AML FLT3+, it was shown that Sorafenib used as maintenance therapy allo-SCT, significantly reduces risk and death. Methods We analyzed 29 adult patients with FLT3m underwent from 2019 to 2023. All received midostaurin plus conventional CT during induction consolidation. After transplantation, administered in all independently MRD status at transplantation. Results...
Purpose To determine genetic features of a pediatric uveal melanoma in 6-year-old girl by array-based comparative genomic hybridization (a-CGH) and assess prognosis, to search for constitutional copy number variations (CNVs) encompassing oncosuppressor genes. Methods High-resolution a-CGH was performed on DNA from cancer cells peripheral blood cells. Histopathology clinical staging the tumor were simultaneously assessed. Results Array-based CGH revealed no CNVs associated with poor...
8081 Background: High-dose (HD) chemotherapy supported by ASCT exhibited promising results in a few, small retrospective series of SCNSL. Herein we report the interim analysis phase II trial (ClinicalTrials.gov #NCT00801216) addressing new R-HDS combination with these poor-prognosis pts. Methods: Pts (≤65 ys old; ECOG PS 0-3) SCNSL at diagnosis or relapse were treated 2 c. HD-methotrexate + HD-cytarabine (induction); 3 sequential HD-cyclophosphamide, HD-cytarabine, HD-etoposide (R-HDS);...