A5006836606- Tryptophan and brain disorders
- Liver Disease Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Stress Responses and Cortisol
- Advanced Neuroimaging Techniques and Applications
- Ferroptosis and cancer prognosis
- Advanced MRI Techniques and Applications
- Drug-Induced Hepatotoxicity and Protection
- Dementia and Cognitive Impairment Research
- Alcohol Consumption and Health Effects
- Liver Diseases and Immunity
- Epigenetics and DNA Methylation
- Bipolar Disorder and Treatment
- Genomics, phytochemicals, and oxidative stress
- Advanced biosensing and bioanalysis techniques
- Multiple Sclerosis Research Studies
- Gold and Silver Nanoparticles Synthesis and Applications
- Immune cells in cancer
- Hepatitis B Virus Studies
- Advanced Photocatalysis Techniques
- Molecular Communication and Nanonetworks
- Electrokinetic Soil Remediation Techniques
- Covalent Organic Framework Applications
- Alzheimer's disease research and treatments
- Heavy metals in environment
Nanchang Hangkong University
2023-2024
Southern Medical University
2020-2023
Fuzhou University
2022
Shenzhen Pingle Orthopedic Hospital
2022
Chongqing University
2018-2021
Background & AimsAcute liver failure (ALF) is a condition with high mortality and morbidity, characterized by glutathione depletion, oxidative stress, mitochondrial dysfunction. Ferroptosis may be involved in ALF. Indeed, emerging studies have shown that ferroptosis plays significant role However, the mechanism of hepatocytes during ALF remains unknown.MethodsHepatic-specific transforming growth factor β receptor 1 knockout (TGFβr1Δhep-CKO) mice nuclear erythroid 2-related 2 (Nrf2-/-) were...
Neuronal iron overload contributes to synaptic damage and neuropsychiatric disorders. However, the molecular mechanisms underlying deposition in depression remain largely unexplored. Our study aims investigate how nuclear factor-erythroid 2 (NF-E2)-related factor (Nrf2) ameliorates hippocampal dysfunction reduces brain functional connectivity (FC) associated with excessive depression. We treated mice chronic unpredictable mild stress (CUMS) chelator deferoxamine mesylate (DFOM) a high-iron...
Acute hepatic damage is a severe condition characterized by inflammation and oxidative stress, which serious threat to people's life health. But there are few effective treatments for acute liver injury. Therefore, safe therapeutic approaches preventing urgently needed. Lupeol natural compound, has significant antioxidant anti-inflammatory properties in disease. However, the protective mechanism of lupeol against injury remains unclear. Here, zebrafish mutant mice were utilized investigate...
Background: The precise physiopathological association between the courses of neurodegeneration and cognitive decline in type 2 diabetes mellitus (T2DM) remains unclear. This study sought to comprehensively investigate distribution characteristics gray matter atrophy middle-aged T2DM patients with newly diagnosed mild impairment (MCI). Methods: Four groups, including 28 early-onset MCI, T2DM, MCI (T2DM-MCI), age-, sex-, education-matched healthy controls underwent 3-dimensional...
Alcoholic liver disease (ALD) has become a heavy burden on health worldwide. Ginsenoside Rb1 (GRb1), extracted from Panax quinquefolium L . , protective effects many diseases, but the effect and mechanisms of GRb1 ALD remain unknown. This study aimed to investigate discover potential mechanisms. Zebrafish larvae were exposed 350 mM ethanol for 32 h establish model acute alcoholic injury, then treated with 6.25, 12.5, or 25 μM 48 h. The human hepatocyte cell line was stimulated by 100...
Most conventional chemotherapeutics indiscriminately kill both cancerous and healthy cells cause toxic side effects, limiting the maximum tolerated dose thereby compromising therapeutic efficacy. To address this challenge, here dual-targeting intelligent DNA guided missile (GM)-integrated nanospacecraft (NSC) (abbreviated as GM-NSC) is demonstrated for staged chemotherapeutic drug delivery exclusively into cancer then mitochondria (not cells). GM-NSC essentially a core/shell nanocomposite...
Patients with type 2 diabetes mellitus (T2DM) are highly susceptible to developing dementia, especially for those mild cognitive impairment (MCI), but its underlying cause is still unclear. This study aims investigate the early detection of white matter structural network changes in T2DM patients MCI and assess relationship between alterations patients. In this study, we performed a battery neuropsychological tests diffusion tensor MRI 30 T2MD-MCI patients, normal cognition (T2DM-NC) age-,...
The aim of this study was to investigate cerebral cortical thickness alterations in patients with type 2 diabetes mellitus (T2DM) and their association mild cognitive impairment (MCI). Thirty T2DM without MCI, 30 healthy controls were recruited. All subjects underwent high-resolution sagittal T1-weighted structural imaging using a 3-dimensional magnetization prepared rapid acquisition gradient echo (MPRAGE) sequence. thicknesses the whole brain 3 groups analyzed compared analysis variance...
Alcoholic liver disease (ALD), recognized as an important health problem worldwide, is a direct consequence of alcohol consumption, which can induce alcoholic fatty liver, steatohepatitis, fibrosis and cirrhosis. p-Hydroxyacetophenone (p-HAP) mainly used hepatoprotective choleretic compound has anti-hepatitis B, antioxidation anti-inflammatory effects. However, no experimental report focused on p-HAP in ALD, the effect mechanism ALD remains mystery. In addition, there research treatment ALD....
Abstract Liver fibrosis is a course of chronic liver dysfunction, can develop into cirrhosis and hepatocellular carcinoma. Inflammatory insult owing to pathogenic factors plays crucial role in the pathogenesis fibrosis. Indoleamine 2,3-dioxygenase 1 (IDO1) affect infiltration immune cells many pathology processes diseases, but its has not been elucidated completely. Here, markedly elevated protein IDO1 livers was identified, dendritic (DCs) immune-phenotypes were significantly altered after...
This study investigated the impact of soil colloidal characteristics on transfer patterns different Cu and Cd speciation in contaminated treated with three amendments: lime (L), zero-valent iron (ZVI), attapulgite (ATP). It seeks to clarify activation hazards aging processes these modifications Cd. Compared control (CK), available concentrations amendments reduced short term (6 months) by 96.49%, 5.54%, 89.78%, respectively, declined 55.43%, 32.31%, 93.80%, respectively. Over a 12-year...
Type 2 diabetes mellitus (T2DM) patients are highly susceptible to developing dementia, especially for those with mild cognitive impairment (MCI), but its underlying cause is still unclear. In this study, we performed a battery of neuropsychological tests and high-resolution sagittal T1-weighted structural imaging explore how T2DM affects white matter volume (WMV) cognition in 30 T2DM-MCI patients, normal (T2DM-NC) age-, sex-, education-matched healthy control (HC) individuals. The WMV the...
Abstract Background Depression is a serious mental illness, which one of the main causes disability at present. The cause and location depression are still unclear. purpose this study to establish stable reliable model non-human primate depression, further confirm significance neuritis in pathogenesis by combining vivo vitro experiments. Methods We simulated environment human established cynomolgus monkeys pro-depressive prodedure (PDP). was evaluated behavioral test neurotransmitter...