A5111853477- Advanced MRI Techniques and Applications
- Functional Brain Connectivity Studies
- Radiopharmaceutical Chemistry and Applications
- Advanced Neuroimaging Techniques and Applications
- Medical Imaging Techniques and Applications
- Gestational Trophoblastic Disease Studies
- Neuropeptides and Animal Physiology
- GABA and Rice Research
- Cerebrovascular and Carotid Artery Diseases
- Chemical Synthesis and Analysis
- Neuroscience and Neuropharmacology Research
- Food Quality and Safety Studies
- Inflammatory mediators and NSAID effects
- Neurosurgical Procedures and Complications
- Receptor Mechanisms and Signaling
- Algebraic Geometry and Number Theory
- Cerebrospinal fluid and hydrocephalus
- Phytoestrogen effects and research
- Advanced Algebra and Geometry
- Reproductive System and Pregnancy
- Cardiovascular Disease and Adiposity
- Intracranial Aneurysms: Treatment and Complications
- Amino Acid Enzymes and Metabolism
- Cancer Research and Treatments
- Infective Endocarditis Diagnosis and Management
RIKEN Center for Biosystems Dynamics Research
2019-2025
Institute for Development and Economic Analysis
2015-2018
The University of Tokyo
2018
Yazaki (United States)
2018
RIKEN Center for Computational Science
2013
Meijo University
2012
Ibaraki University
2011
Showa University
2003-2009
Shionogi (Japan)
1992-2007
National Institute of Technology, Nara College
2007
Macaque monkeys are an important animal model where invasive investigations can lead to a better understanding of the cortical organization primates including humans. However, tools and methods for noninvasive image acquisition (e.g. MRI RF coils pulse sequence protocols) data preprocessing have lagged behind those developed To resolve structural functional characteristics smaller macaque brain, high spatial, temporal, angular resolutions combined with signal-to-noise ratio required ensure...
Abstract We classify nef vector bundles on a smooth hyperquadric of dimension three with first Chern class two over an algebraically closed field characteristic zero. In particular, we see that they are globally generated.
Global glycomics of human whole serum glycoproteins appears to be an innovative and comprehensive approach identify surrogate non-invasive biomarkers for various diseases. Despite the fact that quantitative is premised on highly efficient reproducible oligosaccharide liberation from glycoproteins, it should noted there no validated protocol which deglycosylation efficiency proven quantitative. To establish a standard procedure evaluate N-glycan release by peptide-N-glycosidase F (PNGase F)...
Cyclooxygenase (COX), a prostanoid-synthesizing enzyme, is considered to be involved in the neuroinflammatory process of neurodegenerative diseases. However, role COX progression neurodegeneration not well understood. We hypothesized that vivo imaging by PET will contribute elucidation function during Alzheimer's disease (AD). <sup>11</sup>C-labeled ketoprofen methyl ester (racemic (<i>RS</i>)-<sup>11</sup>C-KTP-Me) developed recently our group useful probe for COX-1 neuroinflammation. The...
Abstract Cortical areas have traditionally been defined by their distinctive layer cyto- and/or myelo- architecture using postmortem histology. Recent studies delineated many measuring overall cortical myelin content and its spatial gradients the T1w/T2w ratio MRI in living primates, including humans. While of areal transitions might benefit from profile this myelin-related contrast, a significant confound is Gibbs’ ringing artefact, which produces signal fluctuations resembling layers....
Mapping the vascular organization of brain is great importance across various domains basic neuroimaging research, diagnostic radiology, and neurology. However, intricate task precisely mapping vasculature regions cortical layers presents formidable challenges, resulting in a limited understanding neurometabolic factors influencing brain’s microvasculature. Addressing this gap, our study investigates whole-brain volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo...
Abstract Functional magnetic resonance imaging (fMRI) of awake macaque monkeys holds promise for advancing our understanding primate brain organization, including humans. However, estimating functional connectivity in animals is challenging due to the limited duration sessions and relatively low sensitivity neural activity. To overcome these challenges, we developed a 24-channel 3T receive radiofrequency (RF) coil optimized parallel macaques. This enabled acquisition multiband...
Localising accurate brain regions needs careful evaluation in each experimental species due to their individual variability. However, the function and connectivity of areas is commonly studied using a single-subject cranial landmark-based stereotactic atlas animal neuroscience. Here, we address this issue small primate, common marmoset, which increasingly widely used systems We developed non-invasive multi-modal neuroimaging-based targeting pipeline, accounts for intersubject anatomical...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTTotal synthesis of kasugamycinY. Suhara, F. Sasaki, G. Koyama, K. Maeda, H. Umezawa, and M. OhnoCite this: J. Am. Chem. Soc. 1972, 94, 18, 6501–6507Publication Date (Print):September 1, 1972Publication History Published online1 May 2002Published inissue 1 September 1972https://pubs.acs.org/doi/10.1021/ja00773a038https://doi.org/10.1021/ja00773a038research-articleACS PublicationsRequest reuse permissionsArticle Views423Altmetric-Citations24LEARN...
A highly potent recombinant L-methionine gamma-lyase (METase) conjugated with polyethylene glycol (PEG) was characterized physicochemically and pharmacokinetically in vivo vitro. Pegylated METase (PEG-METase), which contains pyridoxal 5'-phosphate (PLP) as a cofactor the molecule, is anticancer agent that can deplete from plasma. Although pegylation decreased its specific activity, dithiothreitol (DTT) treatment increased it over three times detachment of one PEG moiety modified cysteine...
The mold Aspergillus oryzae is widely used in Japan as a koji for the fermentation of sake, miso, and soy sauce belongs to genus section Flavi (Gams et al., 1985), which includes A. flavus, sojae, tamarii, parasiticus, nomius.Aspergillus sojae also fermentation.On other hand, nomius are known commonly infect cereal grains peanuts; it kwown that many their isolates produce aflatoxins, carcinogenic secondary metabolites.Many taxonomical studies on these species have been carried out
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTElectrochemical Preparation of Platinum Isocyanide Clusters Containing Chelating Diphosphines. An Unprecedented Trinuclear Complex Involving a Coordinatively Unsaturated Metal Center, [{Pt(diphosphine)(isocyanide)}2Pt](PF6)2Tomoaki Tanase, Hirokazu Ukaji, Yasuko Kudo, Masahiro Ohno, Kimiko Kobayashi, and Yasuhiro YamamotoCite this: Organometallics 1994, 13, 4, 1374–1389Publication Date (Print):April 1, 1994Publication History Published online1 May...
In the present study, we measured accumulation of glutamate after hyperosmotic shock in Escherichia coli growing synthetic medium. The was high medium containing sucrose at a pH above 8 and decreased with decreases pH. same results were obtained when carried out sodium chloride. internal level potassium ions cells higher than that neutral A mutant deficient transport systems for accumulated upon stress without significant increase ions. When osmolarity moderate below 8, E....
The interaction between pullulanase from Klebsiella pneumoniae and alpha-, beta-, gamma-cyclodextrins 6-O-alpha-glucosyl-alpha-cyclodextrin 6-O-alpha-glucosyl-beta-cyclodextrin was examined by means of inhibition studies the enzyme activity, UV difference spectroscopy, flow calorimetry. All above cyclodextrins were found to be competitive inhibitors, but beta-cyclodextrin showed strong inhibition, inhibitor constants being two orders magnitude less than those alpha- gamma-cyclodextrins....
With the objective of minimizing aokusami (beany flavor), which is an undesirable aspect soymilk flavor, we studied effects heating on lipid peroxide content, a factor contributing to beany flavor. We also prepared various desserts containing using this process, and evaluated by sensory test. The content from soaked swollen soybeans steamed at 75°C in relative humidity 80-90% for 10 minutes was substantially lower than that lacked lipoxygenase 14% or less non-heat-treated soybeans....
Mapping the vascular organization of brain is great importance across various domains basic neuroimaging research, diagnostic radiology, and neurology. However, intricate task precisely mapping vasculature regions cortical layers presents formidable challenges, resulting in a limited understanding neurometabolic factors influencing brain's microvasculature. Addressing this gap, our study investigates whole-brain volume using ferumoxytol-weighted laminar-resolution multi-echo gradient-echo...
To keep an enzyme stable in solution, the stabilities of various polyhydric alcohols were investigated, and it was found that 70% aqueous sorbitol solution strikingly against both storage at 33°C heating 80°C. It seems reasonable to ascribe this stability such high osmotic pressure concentration decreased viable counts microorganisms. The reason why is most effective among now being investigated. This will be good advantage as food improver, medicines or so on.
Nucleoside analogs labeled with positrons, such as (11)C and (18)F, are considered valuable in visualizing the proliferative activity of tumor cells vivo using positron emission tomography (PET). We recently developed (11)C-labeled thymidine [(11)C]zidovudine ([(11)C]AZT) [(11)C]stavudine ([(11)C]d4T) via Pd(0)-Cu(I) co-mediated rapid C-C coupling reaction. In this study, to examine whether [(11)C]AZT [(11)C]d4T might be useful for visualization tumors vivo, we performed PET imaging, tissue...