A5084225566- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Immune Response and Inflammation
- Bone Metabolism and Diseases
- Corneal Surgery and Treatments
- Oral microbiology and periodontitis research
- Corneal surgery and disorders
- Alkaline Phosphatase Research Studies
- Bone and Dental Protein Studies
- Ophthalmology and Eye Disorders
- TGF-β signaling in diseases
- Proteoglycans and glycosaminoglycans research
- Healthcare and Venom Research
- Protein Tyrosine Phosphatases
- Microfluidic and Bio-sensing Technologies
- Natural product bioactivities and synthesis
- Migraine and Headache Studies
- Botany, Ecology, and Taxonomy Studies
- NF-κB Signaling Pathways
- Esophageal and GI Pathology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- HIV/AIDS oral health manifestations
- Microfluidic and Capillary Electrophoresis Applications
- S100 Proteins and Annexins
- Bone health and treatments
Kyushu Dental University
2021-2025
Kyoto Prefectural University of Medicine
2012-2016
Doshisha University
2012-2014
Tokyo University of Science
2014
Background/Objectives: Previously, we reported that high molecular weight hyaluronic acid (HMW-HA) exerts chondroprotective effects by enhancing dual specificity protein phosphatase 10/mitogen-activated kinase (MAPK) 5 (DUSP10/MKP5) expression and suppressing inflammatory cytokine-induced matrix metalloproteinase-13 (MMP13) in a human immortalized chondrocyte line (C28/I2 cells) via inhibition of MAPKs. The aim this study was to elucidate the mechanisms underlying enhancement DUSP10/MKP5...
Rebamipide, a gastroprotective drug, has been reported to suppress gastric mucosal inflammation. In Japan, rebamipide eyedrops have recently approved for the treatment of dry eye disease. Some patients with allergic conjunctival diseases such as vernal keratoconjunctivitis (VKC) or atopic (AKC) manifest decreased tear break-up time only. We report VKC/AKC refractory anti-allergic treatments who responded combination and conventional anti-allergic- and/or immunosuppressive/steroid eyedrops....
Chondrogenesis is strictly regulated by several factors, including cytokines, hormones, and extracellular matrix proteins. Mouse teratocarcinoma-derived lineage cells, differentiate into chondrocytes in the presence of insulin. Although ascorbic acid promotes chondrogenic differentiation, detailed regulative mechanisms underlying its role chondrogenesis remain unclear. Therefore, this study, we evaluated effects on insulin-induced differentiation ATDC5 cells intracellular signaling. The...
ABSTRACT Osteoclasts derived from hematopoietic stem cells express immunoreceptors on their cell surface. Previously, we showed that the β‐glucan curdlan suppressed osteoclastogenesis via binding to dectin‐1, a pattern recognition receptor. Curdlan negatively regulates osteoclast differentiation and bone resorption capacity by suppressing expression of nuclear factor activated T 1 (NFATc1), master for differentiation, in dectin‐1‐dependent manner; however, mechanism involved this process has...
Nanoparticles, spherical particles with diameters less than 100 nm, are promising theranostic devices for noninvasive diagnosis and therapy. In this study, nanoparticles composed of polyethylene glycol silica were prepared, their migration behavior was examined using capillary electrophoresis. The effects the sodium dodecyl sulfate concentration in electrolyte, nanoparticle size, encapsulated molecule on examined. addition into electrolyte had a significant effect electrophoretic mobility...
In recent years, magnesium hydroxide has been widely studied due to its bioactivity and biocompatibility. The bactericidal effects of nanoparticles on oral bacteria have also reported. Therefore, in this study, we investigated the biological inflammatory responses induced by periodontopathic bacteria. Macrophage-like cells, namely J774.1 were treated with LPS derived from Aggregatibacter actinomycetemcomitans two different sizes (NM80/NM300) evaluate their response. Statistical analysis was...
Corneal suturing is a surgical procedure used in patients with corneal trauma or transplants. It was reported that endogenous neutrophils are brightly labelled gene-targeted mice expressing enhanced green fluorescent protein (eGFP) under the control of lysozyme M promoter (LysM-eGFP mice).We applied intravital imaging methods to analyse vivo dynamics LysM-positive granulocytes (neutrophils) LysM-eGFP sutures and examined their role elicitation neutrophil infiltration.We found presuturing...
Purpose: To visualize intravital immune cell dynamics in the subconjunctival tissue during wound-healing process using multiphoton microscopy. Methods: Gene-targeted mice expressing enhanced green fluorescent protein under control of endogenous lysozyme M promoter (LysM-eGFP mice) were anesthetized with isoflurane, and injured by a 10-0 nylon conjunctival suture. Vessels visualized intravenous injection 70 kDa rhodamine-conjugated dextran. Using microscope, three-dimensional images acquired...
Background: Periodontal pathogens are related to the incidence of systemic diseases. This study aimed examine whether periodontal pathogen burden is associated with risk fever onset in older adults. Methods: Older adults nursing homes, aged ≥65 years, were enrolled. The was set Kitakyushu, Japan. body temperatures participants ≥37.2 °C and recorded for eight months. As pathogens, Porphyromonas gingivalis, Treponema denticola, Tannerella forsythia qualified by a real-time polymerase chain...
【背景】血友病患者の治療は進歩した。そこで治療の進歩による患者の学校・社会生活の詳細を明らかにするために，母親を対象に，若年世代の患者の学校・社会生活，母親の困り事について実態調査した。 【方法】血友病患者の母親を対象に，無記名自記式の質問紙調査を実施した。 【結果】母親27人の回答が得られ，息子である患者は30人だった。定期輸注実施は23人で，そのうち家庭で輸注を行う者は22人だった。通園経験のある者は27人だった。全ての行事に参加させた者が18人だった。宿泊行事中の定期輸注の実施について，中学生までは学校に支援依頼していた。患者８人は自己注射し，高校生以降の患者４人は，自室で一人の時に注射をしたという回答だった。母親の困り事は「血管確保の失敗と焦り」だった。 【結論】治療の進歩は患者の学校・社会生活を改善した。しかし継続的治療を支える家族の負担のもとに成立する。今後必要な医療支援として，患者の宿泊行事中の輸注において，患者が安心して注射できる場所についての助言が示された。