A5102834284- Diabetes Management and Research
- Growth Hormone and Insulin-like Growth Factors
- Diabetes Treatment and Management
- Pituitary Gland Disorders and Treatments
- Adrenal Hormones and Disorders
- Diabetes and associated disorders
- Hormonal Regulation and Hypertension
- Neuropeptides and Animal Physiology
- Diet and metabolism studies
- Pancreatic function and diabetes
- Cardiovascular Function and Risk Factors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- COVID-19 Clinical Research Studies
- Apelin-related biomedical research
- Cerebrovascular and Carotid Artery Diseases
- Blood Pressure and Hypertension Studies
- Metabolism, Diabetes, and Cancer
- Chronic Kidney Disease and Diabetes
- Cardiovascular Health and Disease Prevention
- Advanced Glycation End Products research
- Male Reproductive Health Studies
- Renal Diseases and Glomerulopathies
- Medication Adherence and Compliance
- Peripheral Artery Disease Management
- Childhood Cancer Survivors' Quality of Life
Istituti Ospitalieri di Cremona
2025
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
2000-2024
University of Brescia
1989-2022
Brescia University
2001
Ospedale Civile Di Ivrea
1997
Medica (Italy)
1991-1994
University of Wisconsin–Milwaukee
1990-1992
It is not presently known whether non-insulin-dependent diabetes mellitus (NIDDM) associated with the presence of structural alterations in small arteries or combination hypertension and NIDDM may have an additive effect on endothelial dysfunction. Therefore, we investigated subcutaneous 12 normotensive subjects (NT group), 18 patients essential (EH 13 NIDDM, 11 EH (NIDDM+EH group).Subcutaneous were evaluated by a micromyographic technique. The internal diameter, media-to-lumen ratio,...
AimsCoronavirus disease (Covid-19) could lead persons with pre-existing medical conditions to severe respiratory infections. The Italian Government introduced quarantine limit viral transmission. This measure people type 1 diabetes (PWT1D) disrupt daily care routine including PA practice difficulties in glycemia management. study aims explore level PWT1D before and during describe variation values.MethodsAn online survey investigating factors the perceived pre-established period after...
Intermittently Scanned Continuous Glucose Monitoring (isCGM) devices are increasingly being used in patients with type 2 diabetes mellitus (T2DM) on insulin therapy for their benefits regarding disease management. Evidence of isCGM use T2DM basal or non-insulin is lacking. This study aimed at assessing the efficacy and safety this population. was an observational, retrospective, real-world enrolling who were starting isCGM. Data from medical records (i.e., demographics, clinical...
Abstract Background Dysphagia is a geriatric syndrome often unrecognized or underestimated, and there lack of studies in heterogeneous population intermediate care (IC) services. This study aims to describe the prevalence dysphagia its association with syndromes older patients IC. Methods Prospective cohort 70 years admitted an IC unit. At admission, severity clinical conditions, comorbidity, delirium, frailty, sarcopenia, nutritional status, medications were assessed. Each patient was...
Arterial hypertension is frequently associated with the presence of endothelial dysfunction in human subcutaneous small resistance arteries, as evaluated by responses to acetylcholine or bradykinin; however it not known whether patients diabetes mellitus show similar alterations. Therefore, we have investigated function arteries normotensive subjects (NT), essential (EH), non-insulin-dependent (NIDDM), well both and (NIDDM+EH).All were submitted a biopsy fat Small dissected mounted on...
Glucocorticoids are thought to inhibit GH secretion through an enhancement of endogenous somatostatin tone. The aim our study was evaluate the effect arginine, a secretagogue that increases acting at hypothalamic level, probably by decreasing tone, on GH-releasing hormone (GHRH)-induced in three male and five female adult patients with nonendocrine disease who were receiving daily immunosuppressive glucocorticoid therapy. Six normal subjects (four males two females) served as controls....
The aim of our study was to analyze the effects sex and age on GH response galanin infusion in healthy subjects. We have studied 12 young (age, < 40 yr) nonobese volunteers [6 females: age, 31.0 +/- 2.5 yr; body mass index (BMI), 21.6 0.9 kg/m2; 6 males: 29.2 1.4 BMI, 23.3 0.4 kg/m2] 11 old > 65 subjects (5 83.8 3.8 23.4 79.7 4.6 0.2 kg/m2). All received an synthetic porcine (500 micrograms, iv) 100 mL saline from 0-45 min. Blood samples for measurement were drawn at -15, 0, 15, 30, 45, 60,...
Glucocorticoids have been shown to inhibit GH secretion in normal man when administered large amounts for several days. The aim of our study was 1. investigate the acute effects a single dose glucocorticoids on man; 2. look at relationship between increase serum cortisol concentration and response stimuli. Six healthy volunteers received three occasions random order an iv injection GHRH (1-29) NH2, 100 micrograms, alone or 60 min after oral administration either 25 50 mg cortisone acetate....
Glucocorticoids have been shown to inhibit GH secretion in normal man when acutely and chronically administered pharmacological amounts. Pyridostigmine (PD), an acetylcholinesterase inhibitor, is able elicit alone enhance the response GHRH subjects probably via a decrease hypothalamic release of somatostatin. The aim present study was investigate influence glucocorticoids on PD either or combination with adult subjects. Six healthy volunteers underwent six experimental protocols. They...
Abstract Background The potential impact of diabetes mellitus type 1 (DM1) on male fertility is currently poorly defined. Hyperglycaemia and insulin deficiency may affect spermatogenesis. Some evidence suggests that men with DM1 have a significant reduction in progressive sperm motility, morphology semen volume, without changes concentration count, but definite data are lacking. Objectives To evaluate the clinical parameters related to analysis. Materials methods We compared court 42...
SUMMARY objectives We aimed to investigate both nocturnal spontaneous and morning growth hormone (GH)‐releasing (GHRH)‐induced GH secretion in children on daily glucocorticoid treatment after liver transplantation evaluate the effect of pyridostigmine (an acetylcholinesterase inhibitor thought reduce hypothalamic somatostatin tone) these patients design performed a randomized, single‐blind, crossover study studied three male female Juvenile patients, within year orthotopic under...
Abstract Background Continuous glucose monitoring (CGM) shows in more detail the glycaemic pattern of diabetic subjects and provides several new parameters (“glucometrics”) to assess patients’ glycaemia consensually guide treatment. A better control levels might result improvement clinical outcome reduce disease complications. This study aimed gather an expert consensus on prognostic use CGM patients at high cardiovascular risk or with heart disease. Methods list 22 statements concerning...
Intermittently Scanned Continuous Glucose Monitoring (isCGM) devices are increasingly being used in patients with type 2 diabetes mellitus (T2DM) on insulin therapy for their benefits regarding disease management. Evidence of isCGM use T2DM treated basal or oral antidiabetic drugs is lacking. The aim this study was to assess the efficacy and safety population. This an observational, retrospective, real-world enrolling who were starting isCGM. Data from medical records (i.e. demographics,...
IDegLira was shown to maintain glycemic control while reducing risk of hypoglycemia and body weight gain. The REX study designed generate real-world evidence on the use in Italian clinical practice two different subgroups patients, those switching from a basal insulin-supported oral therapy (BOT group) plus bolus insulin regimen (BB group). Adult patients with T2D diagnosed for at least 12 months having started 2–3 prior enrolment, coming BOT or BB regimen, were enrolled this multicenter...
The role of glycemic control, both prior and during hospitalization, on mortality from COVID-19 in diabetic patients is debated. Furthermore, it not clear whether hyperglycemia has a direct effect or requires inflammatory mechanisms.To identify predictors clinical outcomes (in-hospital mortality, length respiratory failure, need for intensive care), considering hyperglycemia, inflammation markers history.Retrospective observational study 291 hospitalized with the Spedali Civili di Brescia...
Glucocorticoids are thought to inhibit growth hormone (GH) secretion through an enhancement of endogenous somatostatin tone. The aim our study was evaluate the effects GH-releasing (GHRH) and clonidine, alpha-2-adrenergic agonist which increases GH acting at hypothalamic level with unknown mechanism, on in seven adult patients (3M, 4F) non endocrine diseases daily immunosuppressive glucocorticoid therapy. Eleven normal subjects (7M, served as controls. Steroid-treated showed a blunted...
To characterize patients with APS type 4 among those affected by diagnosed and monitored at our local Reference Center for Autoimmune Polyglandular Syndromes.Monocentric observational retrospective study enrolling in a Center. Clinical records were retrieved analyzed.111 subjects (51 males) 4, mean age the onset was 23.1 ± 15.1 years. In 15 diagnosis of performed during first clinical evaluation, other 96 after latency 11 years (range 1-46). The most frequent diseases I diabetes mellitus...
To investigate the glycated albumin (GA) introduction implications, as an add-on strategy to traditional glycemic control (Hb1Ac and fasting plasma glucose - FPG) instruments, considering insulin-naïve individuals with type 2 diabetes mellitus (T2DM), treated oral therapies.A Health Technology Assessment was conducted in Italy, a multi-dimensional approach useful validate any innovative technology. The HTA dimensions, derived from EUnetHTA Core Model, were deployed by means of literature...
Physical exercise can induce micro-albuminuria, a urinary albumin excretion rate of 20–200 ng/min, in diabetics without micro-.albuminuria at rest (stage II diabetic nephropathy). The aim the present study was to evaluate acute effects captopril, an angiotensin converting enzyme (ACE) inhibitor, and nifedipine, calcium channel blocker, on exercise- induced micro-albuminuria hypertensive with stage nephropathy. Eleven World Health Organisation (WHO) stages l–ll non-obese (five...