A5005493976- Nitric Oxide and Endothelin Effects
- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Blood Pressure and Hypertension Studies
- Cardiovascular Disease and Adiposity
- Cardiovascular Function and Risk Factors
- Receptor Mechanisms and Signaling
- Heart Failure Treatment and Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular and exercise physiology
- Skin and Cellular Biology Research
- Ion Transport and Channel Regulation
- High-Energy Particle Collisions Research
- Cardiovascular Health and Disease Prevention
- Particle physics theoretical and experimental studies
- Dermatological and Skeletal Disorders
- Cellular Mechanics and Interactions
- Advanced Data Compression Techniques
- High Altitude and Hypoxia
- Video Coding and Compression Technologies
- Diabetes Treatment and Management
- Peripheral Artery Disease Management
- Cardiovascular Issues in Pregnancy
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Particle Detector Development and Performance
University of Ferrara
2024
Istituto Nazionale di Fisica Nucleare, Sezione di Ferrara
2024
Sapienza University of Rome
1995-2006
Brescia University
2001
University of Brescia
1997-2000
Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia
1999-2000
Aarhus University
1998
Fondazione Andrea Cesalpino
1993-1996
University of L'Aquila
1994
Endothelin-1 (ET-1) is a potent vasoactive and mitogenic peptide produced by the vascular endothelium. In this study, we evaluated whether insulin stimulates ET-1 secretion human endothelial cells derived from umbilical cord veins permanent hybrid Ea.hy 926. Moreover, to provide evidence that may stimulate in vivo, plasma levels were 7 type II diabetic normotensive males (mean age, 54.3 +/- 4.0 yr) during 2-h hyperinsulinemic euglycemic clamps (287 pmol insulin/m2.min-1) as well 12 obese...
Structural alterations of small arteries in patients with essential hypertension are characterized by inward eutrophic remodeling. However, secondary hypertension, as well experimental models high circulating renin, hypertrophic remodeling, which is smooth muscle cell hypertrophy animal models. The aim our study was to determine whether remodeling subcutaneous forms associated and/or the elastic modulus vessel wall. Fifteen renovascular 9 primary aldosteronism, and 13 normotensive subjects...
This paper presents the successful application of a phase-lock feedback system to maintain resonance condition radio frequency (rf) spin rotator (specifically, an rf Wien filter) with respect 120 kHz precession in Cooler Synchrotron (COSY) storage ring. Real-time monitoring and filter signal allows relative phase between two be stabilized at arbitrary setpoint. The compensates for deviations by adjusting and/or as needed. With this method, variation demand standard deviation...
We evaluated the effects on cardiovascular structure of angiotensin-converting enzyme (ACE) inhibitor enalapril and angiotensin II receptor blocker losartan, administered either at hypotensive or nonhypotensive dosage in spontaneously hypertensive rats (SHR). SHR were treated from ages 4 to 12 weeks with low-dose (1 mg x kg(-1) d(-1)) enalapril, (0.5 high-dose (25 (15 losartan. Untreated WKY also studied. Rats killed 13 age, heart was weighed. Mesenteric small arteries dissected mounted a...
Arterial hypertension is frequently associated with the presence of endothelial dysfunction in human subcutaneous small resistance arteries, as evaluated by responses to acetylcholine or bradykinin; however it not known whether patients diabetes mellitus show similar alterations. Therefore, we have investigated function arteries normotensive subjects (NT), essential (EH), non-insulin-dependent (NIDDM), well both and (NIDDM+EH).All were submitted a biopsy fat Small dissected mounted on...
Objective The time course of programmed cell death (apoptosis) in the vasculature spontaneously hypertensive rats (SHRs) is still unclear. Moreover, no data are presently available about possible interrelationships between apoptosis and vascular remodelling. aim this study was to investigate mesenteric small resistance arteries large (aortas) SHRs normotensive Wistar-Kyoto (WKY) at different ages, before after development overt hypertension. Methods Twenty-four (4, 8 or 12 weeks old) 24...
It was previously observed that a significant regression of structural alterations and endothelial dysfunction in mesenteric small arteries spontaneously hypertensive rats (SHRs) may be obtained after therapy with angiotensin-converting enzyme (ACE) inhibitors. is not clear whether angiotensin II-type 1 receptor blockers share this properties. We evaluated the effects ACE inhibitor enalapril II-receptor blocker candesartan cilexetil on resistance arteries, cardiac mass, function SHRs....
In order to verify the influence of salt sensitivity on blood pressure response orally administered kallikrein, we evaluated efficacy glandular kallikrein (derived from porcine pancreas) in 28 essential hypertensives (21 males and 9 females) aged between 40 62 years. After a placebo run-in period, patients were assigned receive oral therapy (150 IU 3 times day; n = 18 patients) or (n 10 over period 8 days random double-blind fashion. salt-resistant 8), administration did not modify levels....
OBJECTIVE To evaluate the effects of captopril on circulating catecholamine levels in NIDDM patients and possible relationship between captopril-related changes insulin sensitivity. RESEARCH DESIGN AND METHODS Fourteen nonobese normotensive men (aged 44.5 ± 5.1 years) underwent a 2-h euglycemic-hyperinsulinemic clamp (40 mU·m−2 · min−1). Baseline evaluation sensitivity was followed by random assignment each patient to either or placebo treatment, according crossover double-blind design....
OBJECTIVE To evaluate plasma amai natriuretic factor (ANF) behavior in hypertensive patients with either insulin-dependent (type I) or non-insulin-dependent II) diabetes. RESEARCH DESIGN AND METHODS Plasma ANF levels were measured euglycemic normotensive (n = 18) and 18), diabetic I diabetes, n 12; type II 12), 22). In all groups, determined at the end of a normal NaCl diet period (120 mmol per day for 10 days) both supine upright positions. RESULTS significantly higher (P < 0.05)...
We have already demonstrated that maternal consumption of beverages with high polyphenol compounds causes fetal ductal constriction, as a result COX-2 and prostaglandin inhibition. This study tested the hypothesis in normal pregnancies ingestion polyphenol-rich common (MIPRB) interferes flow velocities size right ventricle. A prospective analysis 140 third-trimester fetuses from mothers was carried out, determining systolic diastolic (DFV) to left ventricular dimension ratio. Mean...
Despite the absence of cardiac or renal pathologies, edema and mild hyponatremia may often occur in patients affected by chronic obstructive pulmonary disease (COPD). Therefore, it has been suggested that hypoxia influence release different hormones regulating sodium handling. To evaluate effect hyperoxia O2 removal on plasma digitalis-like substance (DLS) levels, 9 COPD 7 normal subjects were studied. After 1 h supine position, was administered for 3 a tight-fitting face-mask. Blood samples...
Objective To evaluate the functional responses of mesenteric small resistance arteries spontaneously hypertensive rats (SHR) and Wistar–Kyoto (WKY) rat controls to endothelin-1 (ET-1), in presence absence an ETA receptor antagonist drug as well ETB agonist. Methods Twenty aged 12 weeks were studied. They 10 SHR WKY rats. Mesenteric (relaxed diameter 100–180 μm) dissected mounted on a micromyograph (Mulvany's technique). A dose-response curve for response ET-1 was plotted cumulative...
Abstract A series of observations has suggested that one or more digoxin-like immunoreactive substances (DLIS) in biological fluids is able to cross-react with the antidigoxin antibody. Whether this substance endogenous inhibitor Na+/K+ ATPase not been well established. The aim study was identify and characterize DLIS from human urine. Treated urine healthy men run on an affinity chromatography column at a flow rate 1 mL/min which ligand antibody (antiserum) digoxin. Eluates were applied...
The recently installed internal gas target at LHCb presents exceptional opportunities for an extensive physics program heavy-ion, hadron, spin, and astroparticle physics. A storage cell placed in the LHC primary vacuum, advanced Gas Feed System, availability of multi-TeV proton ion beams recent upgrade detector make this project unique worldwide. In paper, we outline main components system, prospects it offers hardware challenges encountered during its implementation. commissioning phase has...
The recently installed internal gas target at LHCb presents exceptional opportunities for an extensive physics program heavy-ion, hadron, spin, and astroparticle physics. A storage cell placed in the LHC primary vacuum, advanced Gas Feed System, availability of multi-TeV proton ion beams, recent upgrade detector make this project unique worldwide. In paper, we outline main components system, prospects it offers, hardware challenges encountered during its implementation. commissioning phase...
The effect of insulin on the vasoconstriction induced by norepinephrine is presently controversial. Therefore, aims our study were: (1) to evaluate low- and high-dose concentration-response curve in small resistance arteries spontaneously hypertensive rats (SHR) Wistar Kyoto (WKY) before after development hypertension, (2) effects antihypertensive treatment vascular response norepinephrine. Fifty-six were included study. Six SHR treated with enalapril 6 candesartan cilexetil from 4th 12th...
It has been suggested that kallikrein-kinin system may influence carbohydrate metabolism via a kinin-mediated increment of insulin-mediated glucose uptake. To evaluate the effect acute inhibition on insulin sensitivity, randomized, placebo-controlled, double-blind study was performed in 15 male non-insulin-dependent diabetic patients. After basal evaluation sensitivity with 2-h euglycaemic hyperinsulinaemic clamp (40 mU m−2 min−1), patients were infused either aprotinin (200 000 U.I.C. as...
s: Wednesday, May 31, 2000: ORAL SESSION 2C: PEPTIDES/CIRCULATING FACTORS/RENIN ANGIOTENSIN SYSTEM
This work investigates a H.264 coding scheme for video transmission over links characterized by heavy packet losses and low available bitrate. The resilient tools such Flexible Macroblock Ordering, Redundant Slices Arbitrary Slice Ordering are here tuned in order to adapt the application layer parameters physical layers characteristics. Due limited bandwidth, differentiated on Region Of Interest. Moreover, tool is integrated suitable level interleaving counteract bursty nature of errors....
Rizzoni, D.; Rodella, L.; Porteri, E.; Rezzani, R.; Guelfi, Piccoli, A.; Castellano, M.; Muiesan, M. Bianchi, Rosei, E. Agabiti Author Information