A5034496669- T-cell and B-cell Immunology
- Pancreatic function and diabetes
- Immune Cell Function and Interaction
- Pancreatic and Hepatic Oncology Research
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Immune responses and vaccinations
- Systemic Sclerosis and Related Diseases
- Neuroendocrine Tumor Research Advances
- Influenza Virus Research Studies
- Immune cells in cancer
- Mental Health Research Topics
- Inflammatory Myopathies and Dermatomyositis
- Child and Adolescent Psychosocial and Emotional Development
- Epigenetics and DNA Methylation
- Molecular Biology Techniques and Applications
- Diabetes and associated disorders
- Immune Response and Inflammation
- Reproductive System and Pregnancy
- Dermatological and COVID-19 studies
- Nutrition, Genetics, and Disease
- Atherosclerosis and Cardiovascular Diseases
- SARS-CoV-2 and COVID-19 Research
- Health, Environment, Cognitive Aging
- Patient Satisfaction in Healthcare
Stanford University
2001-2025
University of California, Los Angeles
2024
Center for Rheumatology
2023
Institute of Infection and Immunity
2023
Stratford University
2020
University of California, San Diego
2015-2018
The University of Sydney
2009
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. Here we develop three protein arrays to measure IgG autoantibodies connective tissue diseases, anti-cytokine antibodies, anti-viral antibody responses in serum from 147 hospitalized patients. Autoantibodies are identified approximately 50% patients but less than 15% healthy controls. When present, largely target autoantigens rare disorders such as myositis, systemic...
Autoimmune diseases disproportionately affect females more than males. The XX sex chromosome complement is strongly associated with susceptibility to autoimmunity. Xist long non-coding RNA (lncRNA) expressed only in randomly inactivate one of the two X chromosomes achieve gene dosage compensation. Here, we show that ribonucleoprotein (RNP) complex comprising numerous autoantigenic components an important driver sex-biased Inducible transgenic expression a non-silencing form male mice...
The microenvironment of pancreatic ductal adenocarcinoma (PDAC) is characterized by a dense fibrotic stroma (desmoplasia) generated cancer-associated fibroblasts (CAFs) derived from stellate cells (PSCs) and (PFs). Using an unbiased GPCRomic array approach, we identified 82 G-protein-coupled receptors (GPCRs) commonly expressed CAFs 5 primary PDAC tumors. Compared with PSCs PFs, have increased expression GPR68 (a proton-sensing GPCR), the results confirmed immunoblotting, Cancer Genome Atlas...
The widespread presence of autoantibodies in acute infection with SARS-CoV-2 is increasingly recognized, but the prevalence non-SARS-CoV-2 infections and critical illness has not yet been reported. We profiled IgG 267 patients from 5 independent cohorts viral, bacterial, noninfectious illness. Serum samples were screened using Luminex arrays that included 58 cytokines 55 autoantigens, many which are associated connective tissue diseases (CTDs). Samples positive for anti-cytokine antibodies...
Abstract Coronavirus Disease 2019 (COVID-19), caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), is associated with a wide range of clinical manifestations, including autoimmune features and autoantibody production. We developed three different protein arrays to measure hallmark IgG autoantibodies Connective Tissue Diseases (CTDs), Anti-Cytokine Antibodies (ACA), anti-viral antibody responses in 147 hospitalized COVID-19 patients centers. Autoantibodies were identified...
Introduction Idiopathic Multicentric Castleman Disease (iMCD) is a polyclonal lymphoproliferative disorder involving cytokine storms that can lead to organ failure and death. The cause of iMCD unknown, but some clinical evidence suggests an autoimmune etiology. For example, connective tissue disorders (CTDs) share many features, autoantibodies have been anecdotally reported in individual patients. This study investigates whether common are shared across Methods We assembled custom bead-based...
Pulmonary fibrosis is a characteristic of various interstitial lung diseases (ILDs) with differing etiologies. Clinical trials in progressive pulmonary (PPF) enroll patients based on previously described clinical criteria for past progression, which include practice guideline PPF classification and inclusion from the INBUILD trial. In this study, we compared ability FVC (forced vital capacity) progression baseline biomarker levels to predict future cohort PFF Patient Registry.
Systemic lupus erythematosus (SLE) is a severe autoimmune disease mediated by pathogenic autoantibodies. While complement protein C4 associated with SLE, its isoforms (C4A and C4B) are not equal in their impact. Despite being 99% homologous, genetic studies identified C4A as more protective than C4B. By generating gene-edited mouse strains expressing either human or C4B crossing these the 564lgi strain, we show that, overall, C4A-like 564Igi mice develop less humoral autoimmunity C4B-like...
BackgroundDepression exerts a staggering toll that is worsened with co-occurring chronic conditions such as obesity. It imperative to develop more effective interventions for depression and identify objective biological plausible neural mechanisms understand intervention outcomes. The current study uses functional neuroimaging determine whether behavioural changes the negative affect circuit these relate subsequent improvements in both symptom problem-solving outcomes depressed patients...
Abstract Background Pulmonary arterial hypertension (PAH) affects approximately 10% of patients with systemic sclerosis (SSc) and is a leading cause death. We sought to identify serum cytokine signatures that risk stratify SSc for this potentially fatal complication. Methods Subjects at high PAH incident based on right heart catheterization (RHC) were enrolled in the multi-center prospective registry, Hypertension Assessment Recognition Outcomes Scleroderma (PHAROS). Low-risk Stanford had...
Background: Family dementia caregivers often suffer from an immense toll of grief while caring for their loved ones. We sought to identify the clinical relationship between grief, depression and mindfulness neural predictors symptomatology improvement. Methods: 23 family were assessed at baseline depression, which 17 underwent functional magnetic resonance imaging (fMRI). During fMRI, shown faces either dementia-stricken relative or that a stranger, paired with grief-related neutral words....
Systemic lupus erythematosus (SLE) affects 1 in 537 Black women, which is >2-fold more than White women. patients develop the disease at a younger age, have severe symptoms, and greater chance of early mortality. We used multiomics approach to uncover ancestry-associated immune alterations with SLE healthy controls that may contribute biologically disparities. Cell composition, signaling, epigenetics, proteomics were evaluated by mass cytometry; droplet-based single-cell transcriptomics...
Abstract The widespread presence of autoantibodies in acute infection with severe respiratory syndrome coronavirus-2 (SARS-CoV-2) is increasingly recognized, but the prevalence infections organisms other than SARS-CoV-2 has not yet been reported. We used protein arrays to profile IgG from 317 samples 268 patients across a spectrum non-SARS-CoV-2 infections, many whom were critically ill pneumonia. Anti-cytokine antibodies (ACA) identified > 50% infected viruses and pathogens, including...
Abstract Background and Aims Current understanding of histone post-translational modifications [histone modifications] across immune cell types in patients with inflammatory bowel disease [IBD] during remission flare is limited. The present study aimed to quantify at a single-cell resolution IBD how they differ compared healthy controls. Methods We performed case-control 94 subjects [83 11 controls]. had either ulcerative colitis [n = 38] or Crohn’s 45] clinical flare. used epigenetic...