Yun Chen

ORCID: 0009-0009-5749-3858
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About
Contact & Profiles
Research Areas
  • Corneal Surgery and Treatments
  • Monoclonal and Polyclonal Antibodies Research
  • Advanced Neuroimaging Techniques and Applications
  • Corneal surgery and disorders
  • Ocular Surface and Contact Lens
  • Advanced MRI Techniques and Applications
  • Medical Imaging Techniques and Applications
  • Glaucoma and retinal disorders
  • Protein purification and stability
  • Medical Imaging and Pathology Studies
  • Radiopharmaceutical Chemistry and Applications
  • Tensor decomposition and applications
  • Viral Infectious Diseases and Gene Expression in Insects
  • 3D Printing in Biomedical Research
  • Galectins and Cancer Biology
  • Radiomics and Machine Learning in Medical Imaging
  • Hydrogels: synthesis, properties, applications
  • Functional Brain Connectivity Studies
  • Plasma Applications and Diagnostics
  • Chemical Synthesis and Analysis
  • Biochemical and Structural Characterization
  • Electricity Theft Detection Techniques
  • Ultrasound in Clinical Applications
  • Cancer, Stress, Anesthesia, and Immune Response
  • Sparse and Compressive Sensing Techniques

The Affiliated Yongchuan Hospital of Chongqing Medical University
2024

Chongqing Medical University
2024

Wuhan Puai Hospital
2024

Citrus College
2023

Jiangnan University
2008-2023

Southeast University
2023

National Cancer Institute
2023

Chinese People's Armed Police Force
2023

Tsinghua University
2018-2022

Nanjing University of Chinese Medicine
2020-2022

Abstract Regeneration of corneal stroma has always been a challenge due to its sophisticated structure and keratocyte-fibroblast transformation. In this study, we fabricate grid poly (ε-caprolactone)-poly (ethylene glycol) microfibrous scaffold infuse the with gelatin methacrylate (GelMA) hydrogel obtain 3 D fiber construct; spacing is adjusted optimal construct that simulates stromal properties most similar native cornea. The topological (3 hydrogel, GelMA 2 culture dish) chemical factors...

10.1038/s41467-020-14887-9 article EN cc-by Nature Communications 2020-03-18

We are investigating the use of an (211)At-labeled anti-CD45 monoclonal antibody (mAb) as a replacement total body irradiation in conditioning regimens designed to decrease toxicity hematopoietic cell transplantation (HCT). As part that investigation, dose-escalation studies were conducted dogs using anticanine CD45 mAb, CA12.10C12, conjugated with maleimido-closo-decaborate(2-) derivative, 4. Unacceptable renal was noted receiving doses 0.27-0.62 mCi/kg range. This result not anticipated,...

10.1021/bc200401b article EN Bioconjugate Chemistry 2012-02-10

Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is characterized by chronic in area and lower urinary tract symptoms (LUTS). Previous neuroimaging studies demonstrated that was associated with the altered brain activity. However, pathological mechanisms control of CP/CPPS are not well-understood. Therefore, we sought to investigate topological properties white matter networks patients whether configuration frontal-parietal network disrupted. We collected 19 32 matched healthy...

10.1111/ejn.14962 article EN European Journal of Neuroscience 2020-09-28

Purpose.: To investigate the exact mechanism by which keratocytes promote corneal neovascularization. Methods.: The expression of matrix metalloproteinase 13 (MMP13), cluster differentiation 146 (CD146), VEGFa, VEGFc, VEGF receptor (r)2, and VEGFr3 normal alkali-burned rat corneas was determined via quantitative (q)RT-PCR and/or Western blot analysis or in situ hybridization. Corneal neovascularization observed under a slit lamp microscope evaluated immunohistochemistry. cells that expressed...

10.1167/iovs.14-14746 article EN Investigative Ophthalmology & Visual Science 2014-09-04

Rehabilitation of lower limb amputation in developing countries is quite challenging. Though there are basic to highly advanced prostheses available India, the set-up still facing difficulties countries. Prosthetic management difficult due lack availability and reduced affordability among low income populations. In this review we highlighted prosthetic rehabilitation status India. Currently, India advancing well field, but further studies required provide more evidence recommendation.

10.12998/wjcc.v11.i30.7380 article EN World Journal of Clinical Cases 2023-10-24

Existing reconstruction methods for single photon emission computed tomography (SPECT) are most based on discrete models, leading to low accuracy in reconstruction. Reconstruction integral equation models (IEMs) with a higher order piecewise polynomial discretization the pixel grid SEPCT imaging were recently proposed overcome deficiency of models. Discretization IEMs leads system large dimension, which may require computational costs solve. We develop SPECT method employs an IEM data...

10.3934/ipi.2019062 article EN cc-by Inverse Problems and Imaging 2019-12-03

Purpose: This study investigates the repairing process of rat cornea after surgery lamellar keratoplasty (LKP) and evaluates effects gelatin methacrylate (GelMA) hydrogel. Methods: In LKP group, stroma matrixes Sprague-Dawley rats were transplanted to enhanced green fluorescent protein rats, whereas those in GelMA group also embedded with a hydrogel during corneal transplantation. Grafted eyes harvested on days seven, 30, 90. Hematoxylin eosin staining, immunofluorescence scanning electron...

10.1167/tvst.10.14.25 article EN cc-by-nc-nd Translational Vision Science & Technology 2021-12-22

To observe the efficacy of vitrectomy with internal limiting membrane (ILM) peeling combined phacoemulsification intraocular lens (IOL) implantation in treatment cataract co-existing macular diseases.A total 28 patients (28 eyes) diseases were admitted to Aier Eye Hospital between May 2008 and 2011. The clinical characteristics analyzed this study. Subjects included 6 men 22 women, aged from 56 77 years (mean 64 years), duration disease ranging 2 36 months 9.3 months). All underwent a...

10.3969/j.issn.1000-4432.2012.01.005 article EN PubMed 2012-03-01

Abstract In 2021, the carbon neutral target was officially included in Chinese government work report, and term has also begun to enter public’s field of vision. This article summarizes research on neutrality. Firstly, introduces basic concept After that, described impact neutrality energy power industries. Finally, from perspective system, this some solutions achieve goal new system. provides references for exploring realization path

10.1088/1755-1315/1011/1/012018 article EN IOP Conference Series Earth and Environmental Science 2022-04-01

Introduction Type 2 diabetes mellitus (T2DM) has been found to be associated with abnormalities of the central and peripheral vascular nervous system, which were considered involved in development cognitive impairments erectile dysfunction (ED). In addition, altered brain function structure identified patients ED, especially psychological ED (pED). However, similarities differences neural mechanisms underlying pED T2DM (DM-ED) remained unclear. Methods Diffusion tensor imaging data acquired...

10.3389/fendo.2022.892563 article EN cc-by Frontiers in Endocrinology 2022-07-27

Diagnostic value of chest computed tomography scan based on artificial intelligence and deep learning in children with lobar pneumonia analysis image features before after treatment: A retrospective cohort study

10.61186/ijrr.22.1.199 article EN cc-by-nc International Journal of Radiation Research 2024-01-01

This paper presents a high-resolution microscale ultrasonic particle image velocimetry technique (termed as Micro-EPIV) for measuring multi-component velocity vectors in opaque flows such blood and biofluid flow microvessel. The method was tested by vitro imaging vivo small animal studies. bioflow were seeded with ultrasound contrast microbubbles, ldquoilluminatedrdquo acoustically 50 MHz 30 ultrasound, respectively. B-mode images obtained at frame rate of 10 frames per second (fps) 110 fps...

10.1109/iembs.2009.5334863 article EN Annual International Conference of the IEEE Engineering in Medicine and Biology Society 2009-09-01
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