A5080876898- Child Nutrition and Water Access
- Gut microbiota and health
- Birth, Development, and Health
- Genetics, Aging, and Longevity in Model Organisms
- Antibiotic Use and Resistance
- Gastroesophageal reflux and treatments
- Gastric Cancer Management and Outcomes
- Spine and Intervertebral Disc Pathology
- Telomeres, Telomerase, and Senescence
- Viral gastroenteritis research and epidemiology
- Global Maternal and Child Health
- Helicobacter pylori-related gastroenterology studies
- Musculoskeletal pain and rehabilitation
- Climate Change and Health Impacts
- Colorectal Cancer Surgical Treatments
- Eosinophilic Esophagitis
- Colorectal Cancer Screening and Detection
- Pregnancy and preeclampsia studies
- Evolution and Genetic Dynamics
University of California, Berkeley
2020-2025
Johns Hopkins Medicine
2025
Johns Hopkins University
2025
University of California, San Diego
2023
Inje University
2014
Abstract Antibiotics can trigger antimicrobial resistance and microbiome alterations. Reducing pathogen exposure undernutrition reduce infections antibiotic use. We assess effects of water, sanitation, handwashing (WSH) nutrition interventions on caregiver-reported use in Bangladesh Kenya, longitudinally measured at three timepoints among birth cohorts (ages 3–28 months) a cluster-randomized trial. Over 50% children used antibiotics least once the 90 days preceding data collection. In...
Gut microbiomes contribute to animal health and fitness. The immense biochemical diversity of bacteria holds particular potential for neutralizing environmental toxins thus helping hosts deal with new toxic challenges. To explore this potential, we used Caenorhabditis elegans harboring a defined microbiome, the antibiotic neomycin as model toxin, differentially affecting microbiome strains, also worms. Worms exposed showed delayed development reduced survival but were protected when...
Abstract Shorter telomere length (TL) is associated with an increased risk for developing chronic or age-related diseases in adults. The process of shortening accelerated response to stress and well characterized adult populations from high-income countries. Prior studies suggest the relationship between stress, shorter TL, disease initiates early life. Nested within WASH Benefits Bangladesh trial, we examined associations parental stressors, including maternal exposure intimate partner...
In the present study, we evaluated efficacy and tolerability between same-day bowel preparation protocols using 2 sachets of Picosulfate a 4 L split-dose polyethylene glycol (PEG) for afternoon colonoscopy.The study had single-center, prospective, randomized, investigator-blinded, non-inferiority design. We quality according to Ottawa scale, patient tolerability, compliance, incidence adverse events, sleep quality, polyp/adenoma detection rate.Among 196 patients analyzed (mean age, 55.3...
Abstract Frequent antibiotic use in areas with high infection burdens can lead to antimicrobial resistance and microbiome alterations. Reducing pathogen exposure child undernutrition reduce infections subsequent use. We assessed effects of water, sanitation, handwashing (WSH) nutrition interventions on pediatric Bangladesh Kenya, using longitudinal data from birth cohorts (at ages 3-28 months) enrolled the WASH Benefits cluster-randomized trials. Over 50% children used antibiotics at least...
Abstract Background and Aims Isolation of Helicobacter pylori is considered difficult because the requirement additional biopsy tissue effort involved in isolation bacterium. We investigated whether H can be cultured from samples used for rapid urease test (RUT). Methods Totally, 174 specimens 87 patients referred endoscopy were prospectively included. During endoscopy, two obtained, one each gastric antrum corpus, placed into a commercially available RUT kit. After detection activity, was...
Nematodes are common in most terrestrial environments, where populations often known to undergo cycles of boom and bust. Useful such scenarios, nematodes present developmental programs diapause, giving rise stress-resistant larvae enabling dispersal search new resources. Best studied Caenorhabditis elegans, stress resistant dauer emerge under adverse conditions, primarily starvation, migrate niches they can resume development reproduce. C. elegans is a bacterivore but has been shown harbor...
Poor immune function increases children's risk of infection and mortality. Several maternal factors during pregnancy may affect infant the postnatal period. We conducted observational analyses within WASH Benefits Bangladesh randomized controlled trial. measured biomarkers in 575 pregnant women postnatally their children. Maternal first second trimester included: nutrition status via vitamin D (25-hydroxy-D [25(OH)D]), ferritin, soluble transferrin receptor (sTfR), retinol binding protein...
Human activity is altering the environment in a rapid pace, challenging adaptive capacities of genetic variation within animal populations. Animals also harbor extensive gut microbiomes, which play diverse roles host health and fitness may help expanding capabilities. The unprecedented scale human usage xenobiotics contamination with environmental toxins describes one challenge against bacteria their immense biochemical diversity would be useful, by increasing detoxification capacities. To...
Esophageal symptoms, that is, heartburn, regurgitation, dysphagia, and chest pain are common in the general population. Also symptoms of back related to pathology lumbosacral spine. The right crus diaphragm forms esophageal hiatus, originates from lumbar spine, may be affected by spine resulting symptoms. We studied whether there was an association between