A5076524804- Silkworms and Sericulture Research
- Silk-based biomaterials and applications
- Fungal Biology and Applications
- Insect Resistance and Genetics
- Web Data Mining and Analysis
- Cancer-related molecular mechanisms research
- Antimicrobial Peptides and Activities
- Topic Modeling
- Natural Language Processing Techniques
- Computational Drug Discovery Methods
- Invertebrate Immune Response Mechanisms
- Entomopathogenic Microorganisms in Pest Control
- Influenza Virus Research Studies
- Advanced Steganography and Watermarking Techniques
- Insect symbiosis and bacterial influences
- Machine Learning in Bioinformatics
- vaccines and immunoinformatics approaches
- Music and Audio Processing
- Genomics and Phylogenetic Studies
- Advanced Text Analysis Techniques
- Chromosomal and Genetic Variations
- Electrospun Nanofibers in Biomedical Applications
- COVID-19 and Mental Health
- Environmental Quality and Pollution
- Circular RNAs in diseases
Jilin University
2024-2025
Beijing Normal University
2025
Gansu University of Traditional Chinese Medicine
2024
University of Hong Kong
2023-2024
HKU-Pasteur Research Pole
2024
Second Hospital of Shandong University
2021-2023
Nanjing University of Science and Technology
2023
Shenzhen Institutes of Advanced Technology
2020-2023
Chinese University of Hong Kong
2023
Guangdong Medical College
2023
The tobacco cutworm, Spodoptera litura, is among the most widespread and destructive agricultural pests, feeding on over 100 crops throughout tropical subtropical Asia. By genome sequencing, physical mapping transcriptome analysis, we found that gene families encoding receptors for bitter or toxic substances detoxification enzymes, such as cytochrome P450, carboxylesterase glutathione-S-transferase, were massively expanded in this polyphagous species, enabling its extraordinary ability to...
Abstract The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire tick virome has not been assessed. We sequenced meta-transcriptomes 31 different species in Ixodidae Argasidae families from across mainland China, identified 724 RNA with distinctive compositions among genera. A total 1,801 assembled complete or nearly viral genomes revealed an extensive diversity genome architectures tick-associated viruses,...
The SilkDB is an open-access database for genome biology of the silkworm (Bombyx mori). Since draft sequence was completed and first released 5 years ago, we have collaborated with other groups to make much remarkable progress on research, such as completion a new high-quality assembly well construction genome-wide microarray survey gene expression profiles. To accommodate these genomic data house more comprehensive information, reconstructed web interfaces. In version (v2.0) SilkDB, updated...
Long noncoding RNAs (lncRNAs) are emerging as important regulators in various biological processes. However, to date, no systematic characterization of lncRNAs has been reported the silkworm Bombyx mori. In present study, we generated eighteen RNA-seq datasets with relatively high depth. Using an in-house designed lncRNA identification pipeline, 11,810 were identified for 5,556 loci. Among these lncRNAs, 474 transcripts intronic (ilncRNAs), 6,250 intergenic (lincRNAs), and 5,086 natural...
The ATP-binding cassette (ABC) superfamily is a large protein family with diverse physiological functions in all kingdoms of life. One distinguished subfamily, the pleiotropic drug resistance (PDR) transporters, has only been identified plants and fungi. Here, we Nicotiana tabacum PDR gene, NtPDR6, which homolog Petunia hybrida PDR1. full-length cDNA NtPDR6 had 4482-bp open reading frame encoding full-size ABC transporter 1493 amino acids. Sequence comparison showed that high homology plant...
Silk proteins are synthesized in the middle and posterior silk glands of silkworms, then transit into anterior gland, where fibers produced, stored processed. The mechanism formation spinning has not been fully elucidated, transcriptome analyses specific to gland have reported. In present study, we explored gene expression profiles five regions samples using RNA-Seq method. As a result, there were 959,979,570 raw reads obtained, which 583,068,172 mapped silkworm genome. A total 7419 genes...
Traditional quantitative structure-activity relationship (QSAR) is a term describing variety of approaches that are substantial interest for chemistry. Quantitative sequence-activity model (QSAM), applying QSAR strategy to explore sequence-activity/function biosystems, greatly meaningful but meanwhile extremely difficult. For biomolecules, high molecular weight, diverse structural morphology and intricate interaction network all bring in traditional methodologies unprecedented challenges....
The wild silkworm Bombyx mandarina is widely believed to be an ancestor of the domesticated silkworm, mori. Silkworms are often used as a model for studying mechanism species domestication. Here, we performed transcriptome sequencing using Illumina HiSeq2000 platform. We produced 100,004,078 high-quality reads and assembled them into 50,773 contigs with N50 length 1764 bp mean 941.62 bp. A total 33,759 unigenes were identified, 12,805 annotated in Nr database, 8273 Pfam 9093 Swiss-Prot...
In recent years, many potential n-type near-room-temperature thermoelectric materials belonging to the [Bi2]m[Bi2Q3]n family have been discovered, whereas new p-type are relatively rare. this study, Sb is doped based on Bi0.6Sb0.4Te by adjusting carrier concentration and then transforms into materials. A novel material, Bi0.45Sb0.55Te, discovered in family. With an increase doping of Sb, leads a significant decrease bipolar diffusion thermal conductivity. Moreover, when >50%, lattice...
Activity cliff (AC) is a phenomenon that pair of similar molecules differ by small structural alternation but exhibit large difference in their biochemical activities. This affects various tasks ranging from virtual screening to lead optimization drug development. The AC has been extensively investigated limited knowledge accumulated about the pharmaceutical peptides with canonical amino acids. study introduces quantitative definition and benchmarking framework AMPCliff for antimicrobial...
Online question-and-answer (Q&A) systems based on the Large Language Model (LLM) have progressively diverged from recreational to professional use. However, beginners in programming often struggle correct code errors independently, limiting their learning efficiency. This paper proposed a Multi-Agent framework with environmentally reinforcement (E-RL) for correction called Code Learning (Co-Learning) community, assisting independently. It evaluates performance of multiple LLMs an...
Nanoparticle-loaded hydrogels - localized drug delivery devices containing a combination of therapeutic nanoparticles and implantable hydrogel have been recipients increased focus interest for cancer treatment. However, it is difficult the released to penetrate deeply into tumors because dense collagen network in tumor extracellular matrix, which greatly limits their antitumor effect. We hypothesized that implantation loaded with both losartan (Los) might enhance penetration Los has proven...
Abstract The complete genome of Cordyceps militaris was sequenced using single-molecule real-time (SMRT) sequencing technology at a coverage over 300×. size 32.57 Mb, and 14 contigs ranging from 0.35 to 4.58 Mb with an N50 2.86 were assembled, including 4 telomeric sequences on both ends additional 8 either the 5′ or 3′ end. A methylome database constructed SMRT m4C m6A methylated nucleotides, many unknown modification types identified. major methylation motif is GA GGAG, GC CG/GC. In C ....
In the silkworm Bombyx mori, pigment mutants with diverse body colors have been maintained throughout domestication for about 5000 years. The larval color is formed through mutual interaction of melanin, ommochromes, pteridines and uric acid. These pigments/compounds are synthesized by cooperative action various genes enzymes. Previous reports showed that ommochrome pteridine increased in quail (q) mutants. To understand increase alterations synthesis q mutant, transcriptome profiles...
Bacillus bombysepticus is a Gram-positive spore-forming bacterium. Here, we announce the first complete genome sequence of this organism isolated from cadavers silkworm larvae that had been sick. The contains single circular chromosome and plasmid. Analyses B. will provide insights into its pathomechanisms biology.
As a master nitrogen regulator in most actinomycetes, GlnR both governs central metabolism and regulates many carbon, phosphate, secondary metabolic pathways. To date, studies have been focused on the regulon, while little is known about transcriptional for glnR itself. It has observed that transcription can be upregulated Mycobacterium smegmatis under nitrogen-limited growth conditions; however, detailed regulatory mechanism still unclear. Here, we demonstrate gene M. transcriptionally...