A5057683990- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- Viral Infections and Immunology Research
- Poxvirus research and outbreaks
- Plant Virus Research Studies
- Herpesvirus Infections and Treatments
- Influenza Virus Research Studies
- Immune Cell Function and Interaction
- Viral gastroenteritis research and epidemiology
- Animal Virus Infections Studies
- SARS-CoV-2 and COVID-19 Research
- Plant and soil sciences
- Agriculture and Farm Safety
- Urticaria and Related Conditions
- Agroforestry and silvopastoral systems
- interferon and immune responses
- Virus-based gene therapy research
- Agricultural and Food Production Studies
- T-cell and B-cell Immunology
- Leptospirosis research and findings
- Viral Infections and Vectors
- Immunodeficiency and Autoimmune Disorders
- Ethics in medical practice
- Diabetes and associated disorders
The Pirbright Institute
2021-2025
Academia Nacional de Medicina
2023
Secretaria de Ciência, Tecnologia e Inovação
2023
United Nations Industrial Development Organization
2023
Georgetown University
2023
Fundação Oswaldo Cruz
2023
Instituto de Saúde
2023
World Health Organization Regional Office for the Americas
2019
Hospital General Universitario Gregorio Marañón
2013
Lumpy skin disease virus (LSDV) is an emerging poxviral pathogen of cattle that currently spreading throughout Asia. The situation high importance for farmers and policy makers in In October 2020, feral Hong Kong developed multi-focal cutaneous nodules consistent with lumpy (LSD). Gross histological pathology further supported the diagnosis samples were sent to OIE Reference Laboratory at Pirbright Institute confirmatory testing. LSDV was detected using quantitative polymerase chain reaction...
In the light of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, we have developed a porcine (PRCV) model for in depth mechanistic evaluation pathogenesis, virology and immune responses this important family viruses. Pigs are large animal with similar physiology immunology to humans natural host PRCV. Four PRCV strains were investigated shown induce different degrees lung pathology. Importantly, although all four replicated equally well cell lines vitro upper tract...
Leptospirosis is an endemic zoonotic disease in Brazil and widespread throughout rural populations the state of Rio Grande do Sul. This study aimed to identify presumptive infecting Leptospira serogroups human animal cases describe their occurrences within ecoregions by species. Data for leptospirosis were gathered from government's passive surveillance systems identified based on a two-fold titer difference microscopic agglutination test (MAT) panel. A total 22 different reported across...
During 2022, outbreaks of foot-and-mouth disease (FMD) were reported across the islands Indonesia, a country that had previously maintained an FMD-free (without vaccination) status since 1990. This report describes near-complete genome sequence representative FMD virus collected from these cases belonging to O/ME-SA/Ind-2001e lineage.
We describe detection of SAT2 topotype XIV foot-and-mouth disease viruses in western Asia during 2022-2023. Sequences show the originated eastern Africa and were introduced into on >1 occasion. The rapid spread naive animals highlights risks for onward transmission potential endemicity Asia.
The pig is a natural host for influenza viruses and integrally involved in virus evolution through interspecies transmissions between humans swine. Swine have many physiological, anatomical, immunological similarities to humans, are an excellent model human influenza. Here, we employed single cell RNA-sequencing (scRNA-seq) flow cytometry characterize the major leukocyte subsets bronchoalveolar lavage (BAL), twenty-one days after H1N1pdm09 infection or respiratory immunization with...
Lumpy skin disease virus (LSDV) is a member of the capripoxvirus (CPPV) genus Poxviridae family. LSDV rapidly emerging, high-consequence pathogen cattle, recently spreading from Africa and Middle East into Europe Asia. We have sequenced whole genome historical isolates Pirbright Institute archive, field recent outbreaks in Sri Lanka, Mongolia, Nigeria Ethiopia. These sequences were compared to published genomes classified different subgroups. Two subgroups contained vaccine or vaccine-like...
Summary Lumpy skin disease virus (LSDV) is an emerging poxviral pathogen of cattle that currently spreading throughout Asia. The situation high importance for farmers and policy makers in In October 2020, feral Hong Kong developed multifocal cutaneous nodules consistent with lumpy (LSD). Gross histological pathology further supported the diagnosis samples were sent to OIE Reference Laboratory at Pirbright Institute confirmatory testing. LSDV was detected using quantitative polymerase chain...
Porcine respiratory disease is multifactorial and most commonly involves pathogen co-infections. Major contributors include swine influenza A (swIAV) porcine reproductive syndrome (PRRSV) viruses. Experimental co-infection studies with these two viruses have shown that clinical outcomes can be exacerbated, but how innate adaptive immune responses contribute to pathogenesis control has not been thoroughly evaluated. We investigated following experimental simultaneous of pigs swIAV H3N2...
Kosovo has previously seen two bluetongue (BT) epizootics, each caused by a different serotype, BTV-9 in 2001 and BTV-4 2014. Since 2014, no clinical cases of BT have been reported Kosovo. In September, 2020, signs suggestive BTV infection were observed several sheep farms Blood samples from (n = 40) collected subjected to further molecular investigations. Molecular analyses confirmed serotype 4 (BTV-4) thirty-six five across regions. Full genome sequence indicated that the strains...
The possible emergence of drug-resistant avian flu raises concerns over the limited effectiveness currently approved antivirals (neuraminidase inhibitors - NAIs) in hypothetical event a zoonotic spillover. Our study demonstrated that recombinant A(H6N1) viruses showed reduced inhibition (RI) by multiple NAI drugs following introduction point mutations found predominantly neuraminidase gene (NA) NAI-resistant human influenza strains (E119V, R292K and H274Y; N2 numbering). Moreover,...
Abstract The pig is a natural host for influenza viruses and integrally involved in virus evolution through interspecies transmissions between humans swine. Swine have many physiological, anatomical, immunological similarities to humans, are an excellent model human influenza. Here, we employed single RNA-sequencing (scRNA-seq) flow cytometry characterize the major leucocyte subsets bronchoalveolar lavage (BAL), twenty-one days after H1N1pdm09 infection or respiratory immunization with...
Nesses últimos vinte anos, cresceu mui¬to a importância de entendermos que esta¬mos todos conectados neste planeta, tam¬bém com os animais, e compartilhamos um ecossistema. Esta ideia é destacada pela abor¬dagem Saúde Única. Existem várias defi¬nições Única (One Health), entre elas elaborada pelo Painel Especialistas Alto Nível em One Health (acrônimo inglês: OHHLEP). Poderíamos sugerir alguns aspectos estão presentes na maioria das definições, eles da colaboração diferentes disciplinas...