A5088202912- melanin and skin pigmentation
- Skin Protection and Aging
- Biochemical Analysis and Sensing Techniques
- RNA regulation and disease
- Olfactory and Sensory Function Studies
- Mast cells and histamine
- Cell Adhesion Molecules Research
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Acne and Rosacea Treatments and Effects
- Hair Growth and Disorders
- Urbanization and City Planning
- Antimicrobial Resistance in Staphylococcus
- Cardiac tumors and thrombi
- Garlic and Onion Studies
- Color Science and Applications
- Autoimmune Bullous Skin Diseases
- Vasculitis and related conditions
- Cancer and Skin Lesions
- Breast Implant and Reconstruction
- Breast Cancer Treatment Studies
- Marine Sponges and Natural Products
- Plant-Microbe Interactions and Immunity
- Immune Cell Function and Interaction
- Genetic and rare skin diseases.
University of the Ryukyus
2025
University of the Ryukyus University Hospital
2024
Yamagata University
2014-2023
Tohoku University Hospital
2002-2022
Kagawa University
2022
Yamagata University Hospital
2022
Niigata University
2021
Okayama University Hospital
2020
Tokyo University of Foreign Studies
2020
The University of Kitakyushu
2020
ABSTRACT RIG-I-like receptors and Toll-like (TLRs) play important roles in the recognition of viral infections. However, how these molecules contribute to defense against poliovirus (PV) infection remains unclear. We characterized sensors PV transgenic mice expressing receptor. observed that alpha/beta interferon (IFN-α/β) production response occurred an MDA5-dependent but RIG-I-independent manner primary cultured kidney cells vitro . These results suggest that, similar RNA other...
Mice and cattle use distinct pathways for the first cell segregation into inner mass (ICM) trophectoderm (TE) lineages at blastocyst stage. However, limited knowledge is available regarding reliable transcriptional networks that orchestrate complex developmental processes this stage in nonrodent species. In order to elucidate site-dominant transcriptomic properties of bovine blastocysts, we separated samples ICM TE using both mechanical chemical methods performed silico prescreening...
Abstract Background Rising seawater temperatures increasingly threaten coral reefs. The ability of larvae to withstand heat is crucial for maintaining reef ecosystems. Although several studies have investigated larvae’s genetic responses thermal stress, most relied on pooled sample sequencing, which provides population-level insights but may mask individual genotype variability. This study uses larval sequencing investigate genotype-specific stress and the selective pressures shaping their...
Summary Hermansky–Pudlak syndrome (HPS) is an autosomal recessive disorder characterized by oculocutaneous albinism (OCA), a bleeding tendency, and ceroid deposition. Most of the causative genes for HPS encode subunits biogenesis lysosome‐related organelles complex (BLOC). In this study, we identified one patient each with HPS4, HPS6, HPS9 whole‐exome sequencing. Next, analyzed hair samples from three patients representative HPS1 controls using electron microscopy chemical methods. All had...
Abstract Albinism, which is commonly inherited as an autosomal recessive trait, characterized by a reduction or absence of melanin in the eyes, skin, and hair. To date, more than 20 causal genes for albinism have been identified; thus, accurate diagnosis requires next‐generation sequencing (NGS). In this study, we analyzed 46 patients who tested negative oculocutaneous (OCA)1–4 Hermansky‐Pudlak syndrome (HPS)1 based on conventional analysis, addition to 28 new Japanese patients, using...
Streptococcus pyogenes causes various diseases in humans. While the prevalence of fluoroquinolone-resistant S. isolates has been increasing since 2000 USA and Europe, it remained very low Japan. We isolated a strain analysed its genetics. TU-296, resistant to levofloxacin (MIC 16 mg/L), was from throat patient their thirties with pharyngitis autumn 2007. carried out susceptibility tests for antimicrobial agents PCR analysis genes gyrA, gyrB, parC parE quinolone resistance-determining region,...
In recent years, not only the residence but also effort of health promotion by improving social environment including working and regional has attracted attention. This paper introduces a subjective assessment tool work environment, referred to as "CASBEE- Office Health Checklist". is an for workers themselves evaluate satisfaction office where spend lot time. By using this tool, people are aware factors that affect intellectual productivity, it expected they can conduct management...
Abstract Human skin color is known to be associated with the risk of cutaneous cancer. Some reports indicated that pigmentation‐related gene variants were cancer in C aucasian populations, but there are no similar East A sian populations. This study aimed evaluate association between genes and J apanese We studied associations 12 four melanin index variations 198 patients compared these findings those 500 controls by using multiple logistic regression analysis. Furthermore, we analyzed an...
Post-inflammatory hyperpigmentation (PIH) is a common cutaneous condition that can cause disfigured appearance. However, the pathophysiology of PIH remains poorly understood, at least in part, because an appropriate animal model for research has not been established. In order to analyze pathomechanism PIH, we successfully induced hairless version transgenic mice (hk14-SCF Tg/HRM) have human-type epidermis containing melanin by repeated hapten application 2,4-dinitrofluorobenzene....
Angiosarcoma of the breast is very rare and can be divided into primary secondary angiosarcoma. Radiation-induced angiosarcoma (RIAS) classified as Diagnosis RIAS difficult due to its rarity, interpretation pathological imaging complicated. In National Comprehensive Care Network (NCCN) guidelines, first choice treatment surgery with negative margins. Adjuvant radiotherapy (RT) for close soft tissue margins should considered. Preoperative or adjuvant chemotherapy nonmetastatic disease not...
Coronavirus disease 2019 (COVID-19) vaccination is recommended for patients with inflammatory bowel (IBD); however, suppressed immune responses have been reported fully vaccinated under immunosuppressive therapy, mainly from Western countries. We prospectively analyzed antibody titers of IBD in Asia induced by two-dose and additional dose messengerRNA COVID-19 vaccine.After measuring high-affinity titers, factors associated were identified multiple regression analyses using the following...
ABSTRACT A 42‐year‐old man was admitted complaining of the sudden onset headache, vomiting, vertigo, and gait disturbance. The authors found hemiparesis his right limbs, Horner's syndrome, decreased pain temperature sensation face left limbs. Diffusion‐weighted imaging (DWI) showed an acute small infarct located on side lateral lower medulla. This is first report Opalski's syndrome with medullary infarction detected by DWI.
Abstract Background Acquired skin hypopigmentation has many etiologies, including autoimmune melanocyte destruction, aging, inflammation, and chemical exposure. Distinguishing lesions from normally pigmented is clinically important to precisely assess disease severity. However, no gold standard assessment method been reported. We aimed investigate whether spectrophotometers are useful for assessing vitiligo rhododendrol (4‐(4‐hydroxyphenol)‐2‐butanol) (Rhododenol ® )‐induced leukoderma...