A5055966066- Colorectal Cancer Surgical Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Ureteral procedures and complications
- Optical Imaging and Spectroscopy Techniques
- Enhanced Recovery After Surgery
- Infrared Thermography in Medicine
- Kidney Stones and Urolithiasis Treatments
- Pediatric Urology and Nephrology Studies
- Surgical Simulation and Training
- Abdominal Surgery and Complications
- Gastric Cancer Management and Outcomes
- Anorectal Disease Treatments and Outcomes
- Nanoplatforms for cancer theranostics
- Endometriosis Research and Treatment
- Aortic aneurysm repair treatments
- Spectroscopy Techniques in Biomedical and Chemical Research
- Organ Transplantation Techniques and Outcomes
- Uterine Myomas and Treatments
- Click Chemistry and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Photodynamic Therapy Research Studies
- Urological Disorders and Treatments
- Photoacoustic and Ultrasonic Imaging
- Colorectal Cancer Screening and Detection
- Esophageal and GI Pathology
Tawam Hospital
2025
Maastricht University Medical Centre
2014-2024
Maastricht University
2014-2024
Institut de Recherche contre les Cancers de l’Appareil Digestif
2020-2023
University Medical Center
2017-2023
Institut de Chirurgie Guidée par l'Image
2020-2022
University of Amsterdam
2019
Jordan Hospital
1999
Background: Ureteral injury during laparoscopic surgery is rare, but when it occurs, can be a serious problem. Near-infrared fluorescence (NIRF) with methylene blue (MB) administration promising technique for easier and potentially earlier intraoperative visualization of the ureter. Aim this prospective study was to assess feasibility NIRF imaging ureter colorectal surgery, using MB. Methods: Patients undergoing were included received intravenous injection MB preoperatively. The visualized...
The development of real-time, wide-field and quantitative diffuse optical imaging methods to visualize functional structural biomarkers living tissues is a pressing need for numerous clinical applications including image-guided surgery. In this context, Spatial Frequency Domain Imaging (SFDI) an attractive method allowing the fast estimation properties using Single Snapshot Optical Properties (SSOP) approach. Herein, we present novel implementation SSOP based on combination deep learning...
Ureteric injury is reported to occur in 1–7.6% of colorectal surgeries. To reduce the incidence ureteral injury, it essential identify ureters. The use near-infrared fluorescence (NIRF) imaging with intravenously administered dyes might be added value for visualization during laparoscopy. aim this study assess performance three preclinical dyes; IRDye® 800BK, 800NOS and 800CW, laparoscopy ureter pigs. In female Dutch landrace pigs, new were evaluated. each pig, 1 dye was tested using a 6-mg...
Hyperspectral imaging (HSI) is a non-invasive modality already applied to evaluate hepatic oxygenation and discriminate different models of ischemia. Nevertheless, the ability HSI detect predict reperfusion damage intraoperatively was not yet assessed. Hypoxia caused by artery occlusion (HAO) in liver brings about dreadful vascular complications known as ischemia-reperfusion injury (IRI). Here, we show evaluation viability an HAO model with artificial intelligence-based analysis HSI. We have...
Mastectomy skin flap necrosis (MSFN) and partial DIEP (deep inferior epigastric artery perforator) loss represent two frequently reported complications in immediate autologous breast reconstruction. These could be prevented when areas of insufficient tissue perfusion are detected intraoperatively. Hyperspectral imaging (HSI) is a relatively novel, non-invasive technique, which used to objectively assess through analysis oxygenation patterns (StO2%), near-infrared (NIR%), hemoglobin (THI%),...
Background: Tonsillectomy and appendectomy are the most frequently performed surgical procedures in pediatric adult populations. However, comprehensive data examining their occurrence within same hospital setting remain sparse. This study aimed to characterize demographic clinical profiles of patients undergoing tonsillectomy assess frequency outcomes those who additionally underwent appendectomy. Methods: A retrospective review was on 337 at a tertiary care from 2015 2017. Data collected...
Abstract Liver ischaemia reperfusion injury (IRI) is a dreaded pathophysiological complication which may lead to an impaired liver function. The level of oxygen hypoperfusion affects the cellular damage during phase. Consequently, intraoperative localisation and quantification impairment would help in early detection ischaemia. To date, there no real-time, non-invasive, tool can compute organ oxygenation map, quantify discriminate different types vascular occlusions intraoperatively....
Ischemia at the site of an intestinal anastomosis is one most important risk factors for anastomotic leakage (AL). Consequently, adequate microperfusion essential optimal tissue oxygenation and healing. As visual inspection viability does not guarantee objective evaluation microperfusion, surgeons are in dire need supportive tools to decrease after colorectal surgery.In this feasibility study, laparoscopic laser speckle contrast imaging (LSCI) was used evaluate experimental ischemic bowel...
Complete mesocolic excision (CME), which involves the adequate resection of tumor-bearing colonic segment with "en bloc" removal its mesocolon along embryological fascial planes is associated superior oncological outcomes. However, CME presents a higher complication rate compared to non-CME resections due risk vascular injury. Hyperspectral imaging (HSI) contrast-free optical technology, facilitates quantitative physiological tissue parameters and visualization anatomical structures. This...
Iatrogenic ureteric injury remains a risk in laparoscopic pelvic procedures. Near-infrared fluorescence (NIRF) imaging is promising new technique for enhanced intraoperative visualization of anatomical structures that could improve the safety surgery. A dye, IRDye® 800-BK, has been developed ureters using NIRF. The present study was first evaluation performance 800-BK during NIRF laparoscopy. This consisted three parts: real-time vivo pigs surgery, ex freshly explanted pig and human ureters....
Dual emissions at ~700 and 800 nm have been achieved from a single NIR-AZA fluorophore 1 by establishing parameters in which it can exist either its isolated molecular or aggregated states.Dual near infrared (NIR) fluorescence color lymph node (LN) mapping with was large-animal porcine model, injection site, channels nodes all detectable both 700 using preclinical open camera system.The also compatible imaging two clinical instruments for guided surgery.Methods: An hydrophilic phobic...
Gastric conduit (GC) is used for reconstruction after esophagectomy. Anastomotic leakage (AL) incidence remains high, given the extensive disruption of gastric circulation. Currently, there no reliable method to intraoperatively quantify perfusion. Hyperspectral imaging (HSI) has shown its potential serosal StO2. Confocal laser endomicroscopy (CLE) allows automatic mucosal microcirculation quantification as functional capillary density area (FCD-A). The aim this study was and GC's...
Abstract Iatrogenic ureteral injuries (IUI) occur in 0.5–1.3% of cases during abdominal surgery. If not recognized intraoperatively, IUI increase morbidity/mortality. A universally accepted method to prevent is lacking. Near-infrared fluorescent imaging (NIRF), penetrating deeper than normal light within the tissue, might be useful, therefore ureter visualization combining NIRF with special dyes (i.e. IRDye 800BK) promising. Aim this work evaluate detection ureters using stents coated a...
Intestinal resection causes inevitable vascular damage, which cannot always be seen during an intraoperative clinical assessment of local intestinal perfusion. If left unaltered, impaired perfusion can lead to complications, such as anastomotic leakage (AL). Therefore, we demonstrate the use a novel laparoscopic laser speckle contrast imaging (LSCI)-based approach in order assess construction anastomoses.Three segments were isolated from small intestine pig, while each was compromised by...
Despite the increasing number of laparoscopic hepatic procedures for resection hepatocellular carcinoma (HCC), intraoperative tumor localization and demarcation remains challenging in comparison to open surgery. In this study, we evaluated feasibility positive liver segment staining through super-selective intra-arterial indocyanine green (ICG) administration.Eight patients presenting with a single HCC underwent an interventional vascular procedure followed by A microcatheter was advanced...
Imaging techniques that enhance visualisation of the anatomy may help prevent bile duct injury. Near-Infrared Fluorescence is such a technique. Previous experiments with ICG have shown illumination extra-hepatic ducts feasible. Yet, there room for improvement in target as compared to background. Experiments IRDye® 800CW show promising results. However, this dye too expensive routine clinical use. The aim study test first applicability two newly developed preclinical dyes regarding...
Transanal total mesorectal excision is a promising novel sphincter-saving procedure for low rectal cancer. However, the transanal bottom-up dissection associated with increased rates of iatrogenic urethral injuries. Near-infrared fluorescence (NIRF) imaging, given its deeper tissue penetration, has been explored in limited number studies enhanced intra-operative visualization. In this study, we feasibility novel, ultrabright, biocompatible fluorescent polymer to coat urinary catheters...