A5032151219- Heavy Metal Exposure and Toxicity
- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Birth, Development, and Health
- Child Nutrition and Water Access
- Maternal Mental Health During Pregnancy and Postpartum
- Energy and Environment Impacts
- Noise Effects and Management
- Health, Environment, Cognitive Aging
- Heavy metals in environment
- COVID-19 and Mental Health
- Trace Elements in Health
- Mercury impact and mitigation studies
- Air Quality Monitoring and Forecasting
- Child and Adolescent Psychosocial and Emotional Development
- Stress Responses and Cortisol
- COVID-19 Pandemic Impacts
- Gestational Diabetes Research and Management
- Bone health and osteoporosis research
- COVID-19 epidemiological studies
- Neonatal Respiratory Health Research
- SARS-CoV-2 and COVID-19 Research
- Infant Development and Preterm Care
- Pregnancy and preeclampsia studies
Columbia University
2023-2025
Mexican Social Security Institute
2020-2024
Center for Children
2024
University of Cundinamarca
2022
Instituto Nacional de Salud Pública
2015-2021
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2016-2021
Science Council
2019
National Institute of Public Health
2019
Instituto Nacional de Salud
2018
National Institute of Public Health
2018
Purpose The Early Life Exposure in Mexico to ENvironmental Toxicants (ELEMENT) Project is a mother–child pregnancy and birth cohort originally initiated the mid-1990s explore: (1) whether enhanced mobilisation of lead from maternal bone stores during poses risk fetal subsequent offspring neurodevelopment; (2) calcium supplementation lactation can suppress mitigate adverse effects exposure on health development. Through utilisation carefully archived biospecimens measure other prenatal...
Lead (Pb) exposure during pregnancy may increase the risk of adverse maternal, infant, or childhood health outcomes by interfering with hypothalamic-pituitary-adrenal-axis function. We examined relationships between maternal blood bone Pb concentrations and features diurnal cortisol profiles in 936 pregnant women from Mexico City. From 2007–11 we recruited hospitals/clinics affiliated Mexican Social Security System. was measured (BPb) second trimester mothers' tibia patella 1-month...
Exposure to endocrine-disrupting chemicals during development may play a role in the increasing prevalence of metabolic syndrome and type 2 diabetes among children adolescents by interfering with homeostasis.To explore associations between utero peripubertal urinary phthalate metabolite bisphenol A (BPA) concentrations markers homeostasis.Early Life Mexico Environmental Toxicants (ELEMENT): longitudinal cohort study pregnant women City their offspring.Public maternity hospitals City.Women...
Prenatal smoke exposure, maternal obesity, aberrant fetal growth, and preterm birth are all risk factors for offspring metabolic syndrome. Cord blood aryl-hydrocarbon receptor repressor (AHRR) DNA methylation is responsive to smoking during pregnancy. AHRR serves not only inhibit (AHR) transcription, which involved in mediating xenobiotic metabolism, but it also cell growth differentiation. Other than smoking, other predictors of status remain unknown; we sought identify them among newborns....
As renal development and maturation processes begin in utero continue through early childhood, sensitive developmental periods arise during which metal exposures can program subclinical nephrotoxicity that manifests later life. We used novel dentine biomarkers of established nephrotoxicants including arsenic (As), cadmium (Cd), lead (Pb), chromium (Cr), lithium (Li), their mixtures, to identify critical windows exposure-associated kidney function alterations preadolescents.Participants...
Postpartum depression (PPD), which affects up to 1 in 5 mothers globally, negatively impacts the health of both and children. Exposure ambient air pollution has been linked depressive symptoms animal models human studies, but relationship between PPD not widely studied. In a birth cohort Mexico City (509 with available data), we examined association exposure particulate matter ≤2.5 μm diameter (PM2.5) psychological dysfunction at 6 months postpartum. Daily PM2.5 estimates were derived from...
Background: Evidence suggests exposure to endocrine-disrupting chemicals (EDCs) can influence Metabolic Syndrome (MetS) risk in adults, but it is unclear if EDCs impact women during midlife. We examined measured adult were predictive of MetS and its components 9 years later. Methods: urinary phthalate metabolites, phenols, parabens collected 2008 among 73 females from the ELEMENT study. (Abdominal Obesity, Hypertriglyceridemia, Cholesterolemia, Hypertension, Hyperglycemia) assessed 2017....
Despite the removal of lead from gasoline in 1997, elevated blood levels (BLLs) > 5 µg/dL are still detectable children living Mexico City. The use lead-glazed ceramics may explain these persistent exposure levels. lacks a national surveillance program for BLL, but temporal trends can be derived epidemiological studies. With this approach, we leveraged series birth cohorts to report BLL 1987 2002 and expanded our analysis 2015. Data were 1–5-year-old five City followed between 1988 BLLs...
Exposure to air pollution is associated with increased blood pressure (BP) in adults and children. Some evidence suggests that exposure during the prenatal period may contribute adverse cardiorenal health later life. Here we apply a distributed lag model (DLM) approach identify critical windows underlie association between particulate matter ≤ 2.5 μm diameter (PM2.5) children's BP at ages 4-6 years.Participants included 537 mother-child dyads enrolled Programming Research Obesity, GRowth...
Satellite-based PM
High blood pressure (BP) in childhood is frequently renal origin and a risk factor for adult hypertension cardiovascular disease. Shorter gestations are known increased BP adults children, due part to nephron deficit children born preterm. As nephrogenesis incomplete until 36 weeks gestation, prenatal lead exposure occurring during susceptible period of development may contribute programming later life The relationship between shorter gestation children's has not yet been explored identify...
To estimate the prevalence of elevated (≥5.0μg /dL) blood lead levels (BLL) and its association with use glazed ceramics (LGC).In 2018, we measured capillary BLL in a representative sample children 1 to 4 years old residing Mexican localities under 100 000 inhabitants (Ensanut 100k). We inquired about LGC for food preparation consumption. BLL, multinomial logit models stratified by region were generated.The was 21.8%. For North, Central South regions, 9.8, 20.7 25.8%, respectively. The...