Erica L. Kleinbrink
A5082406605- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Genetic Associations and Epidemiology
- RNA modifications and cancer
- Acute Myeloid Leukemia Research
- Estrogen and related hormone effects
- Epigenetics and DNA Methylation
- RNA and protein synthesis mechanisms
- Pancreatic function and diabetes
- Histone Deacetylase Inhibitors Research
- RNA regulation and disease
- Diet, Metabolism, and Disease
- Chromosomal and Genetic Variations
- Ion channel regulation and function
- Circular RNAs in diseases
- Ion Transport and Channel Regulation
- CRISPR and Genetic Engineering
- Helicobacter pylori-related gastroenterology studies
- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- interferon and immune responses
- Metabolism, Diabetes, and Cancer
- Protein Degradation and Inhibitors
- Genetic Mapping and Diversity in Plants and Animals
Wayne State University
2016-2023
McGill University
2023
University of Michigan
2010-2013
The link between DNA methylation, obesity, and adiposity-related diseases in the general population remains uncertain.We conducted an association study of body mass index (BMI) differential methylation for over 400,000 CpGs assayed by microarray whole-blood-derived from 3,743 participants Framingham Heart Study Lothian Birth Cohorts, with independent replication three external cohorts 4,055 participants. We examined variations whole blood gene expression Mendelian randomization analyses to...
Aims: Causal transcripts at genomic loci associated with type 2 diabetes are mostly unknown. The chr8p23.1 variant rs4841132, an insulin resistant risk phenotype, lies in the second exon of a long non-coding RNA (lncRNA) gene, LOC157273, located 175 kilobases from PPP1R3B, which encodes key protein regulating insulin-mediated hepatic glycogen storage humans. We hypothesized that LOC157273 regulates expression PPP1R3B human hepatocytes. Methods: tested our hypothesis using Stellaris...
In the post-genomic era, our understanding of molecular regulators physiologic and pathologic processes in pregnancy is expanding at whole-genome level. Longitudinal changes known protein-coding transcriptome during normal pregnancy, which we recently reported (Gomez-Lopez et al., 2019), have improved definition major operant networks, yet pregnancy-related functions non-coding RNA remain poorly understood. A key finding ENCODE (Encyclopedia DNA Elements) Consortium, successor Human Genome...
Long non-coding RNAs (lncRNAs) are transcripts of a recently discovered class genes which do not code for proteins. LncRNA approximately as numerous protein-coding in the human genome. However, comparatively little remains known about lncRNA functions. We globally interrogated changes transcriptome oestrogen receptor positive breast cancer cells following treatment with oestrogen, and identified 127 oestrogen-responsive lncRNAs. Consistent emerging evidence that most lack homologues outside...
Summary Metabolic dysregulation in multiple tissues alters glucose homeostasis and influences risk for type 2 diabetes (T2D). To identify pathways influencing T2D-relevant glycemic traits (fasting [FG], fasting insulin [FI], two-hour [2hGlu] glycated hemoglobin [HbA1c]), we investigated associations of exome-array variants up to 144,060 individuals without ancestries. Single-variant analyses identified novel at 21 coding 18 loci, whilst gene-based tests revealed signals two genes, TF (HbA1c)...
Genome-wide association studies for glycemic traits have identified hundreds of loci associated with these biomarkers glucose homeostasis. Despite this success, the challenge remains to link variant associations genes, and underlying biological pathways.
Autoantibodies against mitochondrial-derived antigens play a key role in chronic tissue inflammation autoimmune disorders and cancers. Here, we identify autoreactive nuclear genomic DNA (nDNA)-encoded mitochondrial gene products (GAPDH, PKM2, GSTP1, SPATA5, MFF, TSPOAP1, PHB2, COA4, HAGH) recognized by breast cancer (BC) patients' sera as nonself, supporting direct relationship of autoimmunity to carcinogenesis. Autoreactivity multiple nDNA-encoded was mapped protein-coding regions, 3'...
One of the major discoveries early post-genomic era, as embodied by gene catalogs FANTOM and ENCODE (Encyclopedia DNA Elements) consortia, is that two-thirds human genes do not encode known proteins. Those ~40,000 non-protein-coding (non-coding RNA) (www.gencodegenes.org) remain poorly understood. Long non-coding RNA (lncRNA) are most numerous category ncRNA genes. Hundreds lncRNAs have recently-discovered functions now understood to be fundamental nuclear cytoplasmic, epigenetic...
Metabolic dysregulation in multiple tissues influences risk for type 2 diabetes (T2D). To identify pathways and influencing T2D-relevant glycemic traits we investigated associations of exome-array variants up to 144,060 nondiabetic individuals ancestries. Single-variant analyses identified 21 novel coding variant (18 loci), whilst gene-based tests revealed signals at TF (HbA1c) G6PC [(Fasting Glucose (FG), Fasting Insulin (FI)]. Pathway tissue enrichment trait-associated transcripts...
Abstract Aims Causal transcripts at genomic loci associated with type 2 diabetes are mostly unknown. The chr8p23.1 variant rs4841132, an insulin resistant risk phenotype, lies in the second exon of a long non-coding RNA (lncRNA) gene, LOC157273 , located 175 kilobases from PPP1R3B which encodes key protein regulating insulin-mediated hepatic glycogen storage humans. We hypothesized that regulates expression human hepatocytes. Methods tested our hypothesis using Stellaris fluorescent in-situ...