A5086148274- Sexual function and dysfunction studies
- Sexuality, Behavior, and Technology
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- Genital Health and Disease
- Cancer-related molecular mechanisms research
- Hypothalamic control of reproductive hormones
- Chromatography in Natural Products
- Virus-based gene therapy research
- Magnetic properties of thin films
- MicroRNA in disease regulation
- Phytochemical Studies and Bioactivities
- RNA modifications and cancer
- Toxoplasma gondii Research Studies
- Extracellular vesicles in disease
- Barrier Structure and Function Studies
- Reproductive tract infections research
- RNA Research and Splicing
- Viral Infectious Diseases and Gene Expression in Insects
- Genetic Syndromes and Imprinting
- Traditional Chinese Medicine Analysis
- Magnetic Properties and Applications
- Pharmacogenetics and Drug Metabolism
- Semiconductor materials and devices
- Natural product bioactivities and synthesis
Fujian Institute of Research on the Structure of Matter
2025
South China Agricultural University
2025
Shenzhen Technology University
2024
Wannan Medical College
2023
First Affiliated Hospital of Wannan Medical College
2023
First Affiliated Hospital of Anhui Medical University
2015-2022
Anhui Medical University
2015-2022
GlobalFoundries (Singapore)
2020-2022
Tongji University
2019-2021
Nanjing Medical University
2021
IL-8 plays an integral role in promoting the malignant phenotype breast cancer, and its production is directly influenced by inflammatory cytokines tumor microenvironment. Here, we show that activation of IL-1beta receptors on HS578t MDA-MB-231 cancer cells strongly induces expression RNA stabilization persistently activated at least 12-24 hr after stimulation. SB 203580 rapamycin reversed effect a dose-dependent manner, suggesting involvement p38/MAP kinase mTOR pathways. A luciferase...
The prognosis for patients with head and neck cancer (HNC) remains poor, owing to uncontrolled tumor invasion metastasis. Epithelial-mesenchymal transition (EMT) serves an important role in this metastasis, transient receptor potential polycystic 2 (TRPP2) enhances metastasis by regulating EMT human laryngeal squamous cell carcinoma. present study examined whether exosomes/TRPP2 small interfering RNA (siRNA) complexes were able reduce suppressing TRPP2 expression FaDu cells, a line of...
We demonstrate highly reliable and mass-production ready 22nm FD-SOI 40Mb embedded-MRAM for industrial-grade (-40~125°C) applications. This technology having 5x solder reflows compatibility stack has passed JEDEC standard qualification (ECC-OFF) with total reliability failures below the product life-time bit-failure-rate requirement industrial-grade. Using design-process co-optimization, we show extended performance to meet -40~150°C operation Auto-Grade-1 applications stable read...
BACKGROUND:MicroRNAs (miRNAs) play pivotal roles in spermatogenesis. MicroRNA-210 (miR-210) expression was up-regulated the testes of sterile men with non-obstructive azoospermia (NOA). However, underlying mechanisms miR-210 involved spermatogenesis patients NOA are unknown.MATERIAL AND METHODS:Expression and insulin-like growth factor II (IGF2) cases (only including maturation arrest hypospermatogenesis) were detected this study. We carried out vitro experiments to determine if IGF2...
Lead is one of the most common heavy metal pollutants in environment. Prolonged exposure to lead will induce oxidative stress, inflammation, and apoptosis kidneys, which turn causes kidney injury. Lycium barbarum polysaccharide (LBP) well known for its numerous pharmacological properties. This study aims explore efficacy mechanism LBP against lead-induced damage mice. Symptoms renal injury were induced mice by using 25 mg/kg acetate (PbAc2), different doses (200, 400, 600 BW) orally...
Abstract The synthesis of diethyl carbonate (DEC) faces several challenges, including the difficulty in separating and recycling highly active organic alkali catalysts, poor catalyst stability, high operational costs associated with traditional transesterification methods. Additionally, industrial processes often suffer from low production capacity slow reaction kinetics. In this study, we explore catalytic performance various metal‐compound‐based catalysts supported on commercial activated...
Avian influenza viruses (AIVs) are potential pandemic of global concern, posing a major threat to both the poultry industry and human health. Host factors play key role in replication AIVs, while function complement component 4 binding protein, membrane (C4BPM) this process is still unclear. This research reports that C4BPM promotes H5N1 H9N2 AIVs by inhibiting type I interferons (IFNs). infection up-regulate expression chicken embryo fibroblast cells (DF-1). To verify knockout (C4BPM-KO)...
Abstract Background In the Greater Mekong sub-region, Plasmodium vivax has become predominant species and imposes a major challenge for regional malaria elimination. This study aimed to investigate variations in genes potentially related drug resistance P. populations from China–Myanmar border area. addition, this also wanted determine whether divergence existed between parasite associated with asymptomatic acute infections. Methods A total of 66 isolates were obtained patients who attended...
Abstract Cancer is one of the most fatal diseases that threaten human health, whereas more than 90% mortality cancer patients caused by tumor metastasis, rather growth primary tumors. Thus, how to effectively control or even reverse migration cells great significance for therapy. CtBP, a transcriptional cofactor displaying high expression in variety cancers, has become main targets prediction, diagnosis, and treatment. The roles CtBP promoting tumorigenesis have been well studied vitro,...
Abstract Purpose Testosterone deficiency and changes in testosterone levels are important men's health may be associated with fat accumulation. In order to investigate the connection between accumulation adult males, we employed lipid product compared it triglyceride–glucose Homeostasis Model Assessment of Insulin Resistance. Materials methods An intersecting surface research participators from 2013 2014 was carried out using National Health Nutrition Examination Survey, addition,...
Introduction There are limited data on the treatment satisfaction with dapoxetine in patients premature ejaculation (PE). Aims We aimed to evaluate satisfaction, effectiveness and safety of for PE patients. Methods Subjects received (30 mg or 60 mg) alone combination a phosphodiesterase type 5 inhibitor, if concurrent erectile dysfunction more than 4 weeks clinical practice. Main outcome measures include Clinical Global Impression Change (CGIC) Satisfaction (CGIS). Results From March 2014...
Abstract Dysregulation of autophagy is associated with the neurodegenerative processes in Alzheimer's disease (AD), yet it remains controversial whether a cause or consequence AD. We have previously expressed full‐length human APP Drosophila and established fly AD model that exhibits multiple AD‐like symptoms. Here we report depletion CHIP effectively palliated APP‐induced pathological symptoms, including morphological, behavioral, cognitive defects. Mechanistically, required for...
BACKGROUND The STin2 VNTR polymorphism has a variable number of tandem repeats in intron 2 the serotonin transporter gene. We aimed to explore relationship between and lifelong premature ejaculation (LPE). MATERIAL AND METHODS recruited total 115 outpatients who complained ejaculating prematurely were diagnosed as LPE, 101 controls without PE complaint. Allelic variations genotyped using PCR-based technology. evaluated associations allelic genotypic frequencies well intravaginal latency time...
Abnormal phosphorylation of claudins changes the interaction and aggregation tight junction proteins, affecting intestinal epithelial barrier. Selective blockade transient receptor potential vanilloid 4 (TRPV4) alleviated experimental colitis. Whether TRPV4 affects barrier relationship to claudin-7 remain unknown. In present study, we investigated expression in human colonic tissues cells. Using site-directed mutagenesis approach, also identified roles between phosphorylation. Increased was...
BACKGROUND:This study aimed to explore the relationship between premature ejaculation (PE) and serotonin transporter gene-linked polymorphic region (5-HTTLPR) with respect biallelic triallelic classifications. MATERIAL AND METHODS:A total of 115 outpatients who complained ejaculating prematurely were diagnosed as having lifelong (LPE) 101 controls without PE complaint recruited. All subjects completed a detailed questionnaire genotyped for 5-HTTLPR polymorphism using PCR-based technology. We...
The purpose of the study is to evaluate relationship between NIH-CPSI and IIEF-5 in Chinese men with CP/CPPS. A large cross-sectional multicenter survey was conducted from July 2012 January 2014. Men were recruited urology clinics which located at five cities China. All participated by completing a verbal questionnaire (consisted sociodemographics, past medical history, sexual self-estimated scales). results showed that 1,280 completed survey. Based on CP/CPPS definition, total 801 diagnosed...
Cutaneous squamous cell carcinoma (CSCC) is the second most common worldwide. Clinical treatment for patients with CSCC remains non-ideal. Insulin-like growth factor binding protein 3 (IGFBP3), a member of insulin-like (IGF) system, participates in several biological processes, including cellular proliferation and apoptosis. Here, we explored functional role IGFBP3 apoptosis A431 cells, human line.Differential expression analysis, immunohistochemistry, immunoblotting, TUNEL assay, CCK8 assay...
TRPV4 is a type of nonselective cation channel, and activation in the gastrointestinal tract causes experimental colitis mice. A previous study found that tyrosine-phosphorylated claudin-7 increased colitis. The relationship between remains undefined. In present study, we developed mutant by replacing tyrosine with glutamic acid at position 210, named cld7-Y210E colonic cells. We GSK1016790A permeability control cell monolayers, which was decreased antagonist HC067047. monolayers cells, no...
Opa interacting protein 5 (OIP5), which is a cancer/testis-specific gene, plays cancer-promoting role in various types of human cancer. However, the OIP5 carcinogenesis and progression ovarian cancer remains unknown.We first analyzed expression tumors with Sangerbox online analysis tool. GSE12470, GSE14407 GSE54388 were downloaded from Gene Expression Omnibus (GEO) database, GEO2R was used to screen differentially expressed genes tissues. Ontology (GO) enrichment explore related biological...