A5102922131- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cardiac Valve Diseases and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Infective Endocarditis Diagnosis and Management
- Cardiac Imaging and Diagnostics
- Orthopedic Surgery and Rehabilitation
- Colorectal Cancer Treatments and Studies
- Retinal Imaging and Analysis
- Lung Cancer Treatments and Mutations
- Acute Ischemic Stroke Management
- Advanced Neuroimaging Techniques and Applications
- Shoulder Injury and Treatment
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Aortic Disease and Treatment Approaches
- Cardiovascular Disease and Adiposity
- Elbow and Forearm Trauma Treatment
- Shoulder and Clavicle Injuries
- Diabetes Management and Research
- Antimicrobial Resistance in Staphylococcus
- Diabetes Treatment and Management
- Venous Thromboembolism Diagnosis and Management
- Mechanical Circulatory Support Devices
- Clinical Laboratory Practices and Quality Control
Semmelweis University
2016-2025
Institut Gustave Roussy
2015-2021
Université Paris-Saclay
2017
Gottsegen National Cardiovascular Center
2003-2016
Université Paris-Sud
2015
The EURO-ENDO registry aimed to study the management and outcomes of patients with infective endocarditis (IE).Prospective cohort 3116 adult (2470 from Europe, 646 non-ESC countries), admitted 156 hospitals in 40 countries between January 2016 March 2018 a diagnosis IE based on ESC 2015 diagnostic criteria. Clinical, biological, microbiological, imaging [echocardiography, computed tomography (CT) scan, 18F-fluorodeoxyglucose positron emission tomography/computed (18F-FDG PET/CT)] data were...
Non-small-cell lung cancer (NSCLC) with a mutation in the gene encoding epidermal growth factor receptor (EGFR) is sensitive to approved EGFR inhibitors, but resistance develops, mediated by T790M most cases. Rociletinib (CO-1686) an inhibitor active preclinical models of EGFR-mutated NSCLC or without T790M.In this phase 1-2 study, we administered rociletinib patients who had disease progression during previous treatment existing inhibitor. In expansion (phase 2) part T790M-positive received...
Abstract Aims The European Society of Cardiology (ESC) EURObservational Research Programme (EORP) Endocarditis (EURO-ENDO) registry aims to study the care and outcomes patients diagnosed with infective endocarditis (IE) compare findings recommendations from 2015 ESC Clinical Practice Guidelines for management IE data 2001 Euro Heart Survey. Methods results Patients (n = 3116) aged over 18 years a diagnosis based on diagnostic criteria were prospectively identified between 1 January 2016 31...
A complete circle of Willis (CoW) is considered an important collateral network to maintain blood flow during cross-clamping in carotid endarterectomy (CEA). The aim this study was evaluate the impact incomplete CoW with isolated middle cerebral artery (iMCA) on immediate neurologic events (INEs) after CEA.We prospectively collected clinical data and outcomes 902 patients who underwent CEA under general anesthesia between 2013 2015. All had preoperative computed tomography angiography...
Abstract Unhealthy vascular aging promotes atherogenesis, which may lead to significant internal carotid artery stenosis (CAS) in 5 7.5% of older adults. The pathogenic factors that promote accelerated and CAS also affect the downstream portion cerebral microcirculation these patients. Primary treatments are eversion endarterectomy or with patch plasty. Factors determine adequate hemodynamic compensation thereby clinical consequences as well medical surgical complications reconstruction...
To test utility of diffusion MRI-derived indices in carotid endarterectomy (CEA), change tensor imaging (DTI) metrics, cerebral white matter (WM) volumes were evaluated and predictors overall mortality determined. Prospectively enrolled participants had preoperative, immediate late postoperative DTI after CEA. WM volumes, metrics (fractional anisotropy, FA; axial, radial, mean diffusivities; AD, RD, MD, respectively) calculated for the index/contralateral hemispheres at all time points....
Abstract Pathophysiological mechanisms underlying hematoma expansion in spontaneous intracerebral hemorrhage (ICH) remain poorly understood, and most data are derived from postmortem studies or serial neuroimaging performed over hours to days onset. Our unique case report of a hypertensive ICH serendipitously captured by CT provides valuable vivo the very onset formation an aging individual. A 76-year-old man underwent elective carotid angiography evaluate previously known asymptomatic right...
(1) to estimate the prevalence of Circle Willis (CoW) variants in patients undergoing carotid endarterectomy, (2) correlate these controls and (3) cerebral ischemia depicted by computed tomography (CT).After Institutional Review Board approval, data 544 endarterectomy (331 males, mean age 69±8 years) 196 (117 66±11 who underwent brain CT angiography (CTA) were retrospectively analysed. Two observers independently classified each CoW segment as normal, hypoplastic (diameter <0.8 mm) or...
Carotid artery stenosis (CAS) is among the leading causes of mortality and permanent disabilities in Western world. CAS a consequence systemic atherosclerotic disease affecting majority aging population. Optical coherence tomography angiography (OCTA) novel imaging technique for visualizing retinal blood flow. It noninvasive, fast method qualitative quantitative assessment microcirculation. Cerebral circulation share similar anatomy, physiology, embryology; thus, microvasculature provides...
Whether hypoattenuated leaflet thickening (HALT) following transcatheter aortic valve implantation (TAVI) carries a risk of subclinical brain injury (SBI) is unknown. We investigated whether HALT associated with SBI detected on magnetic resonance imaging (MRI), and post-TAVI impacts the patients' cognition outcome. prospectively enrolled 153 patients (age: 78.1 ± 6.3 years; female 44%) who underwent TAVI. Brain MRI was performed shortly 6 months later to assess occurrence acute silent...
The Circle of Willis (CoW) is the main collateral system, and its morphological variants are more common in patients who have severe carotid artery stenosis. Earlier data suggest that optical coherence tomography angiography (OCTA) may help to assess changes cerebral vascular perfusion by imaging retinal blood flow. In this single-center prospective clinical study, scheduled for endarterectomy (CEA) underwent preoperative computed (CTA) extra- intracranial circulation. OCTA was performed one...
Nosocomial bloodstream infection (BSI) is a common finding in cardiac surgery intensive care units and associated with excess mortality hospital costs. Additional data are needed about incidence, characteristics, predictors, microorganisms of nosocomial BSI surgical patients order to refine measures prevent infections improve recovery outcomes this patient population. The 3912 cardio-thoracic from all age groups were admitted the study at Gottsegen György Hungarian Institute Cardiology...
Aims To evaluate the patient- and procedure-related predictors of transcatheter aortic-valve implantation (TAVI)-associated ischemic brain lesions to assess effect silent cerebral (SCIL) on neurocognitive function. Methods results We investigated 113 consecutive patients with severe aortic stenosis who underwent magnetic resonance imaging (MRI) within a week following TAVI. periprocedural lesions, diffusion-weighted MRI was utilized. used multivariate linear regression identify independent...
(1) Study purpose: The aim of our prospective single-center, matched case-control study was to compare the number and volume acute ischemic brain lesions following carotid endarterectomy (CEA) versus artery stenting (CAS) using a propensity-matched design. (2) Methods: Carotid bifurcation plaques were analyzed by VascuCAP software on CT angiography (CTA) images. chronic assessed MRI scans taken 12-48 h after procedures. Propensity score-based matching performed at 1:1 ratio...
Abstract Aims Our aim was to establish an objective, quantitative methodology for volumetric hypo-attenuated leaflet thickening (HALT) diagnosis and evaluate its clinical significance. Methods results We prospectively enrolled 144 patients who underwent transcatheter aortic valve implantation (TAVI) between 2011 2016. At inclusion, cardiac computed tomography angiography (CTA), transthoracic echocardiography, brain magnetic resonance imaging (MRI) were performed. quantified HALT on CTA...
268 Background:Abiraterone acetate (A) and cabazitaxel (C) improve survival for patients with mCRPC. We conducted an open-label trial of A+C to assess the antitumor activity tolerability combination in (pts) previously treated docetaxel (D) A (NCT01511536). Here, we report results phase 2 part study, after MTD was established (Massard C, et al. ASCO 2013). Methods: Pts received (1,000 mg QD) C (25 mg/m every 3 weeks) prednisone/ prednisolone (5 BID). Eligibility criteria included prior D at...
In previous research conducted at our center in 2015, we found a strong association between missing Circle of Willis (CoW) segments and immediate neurologic events, with an odds ratio 11.12. Based on these findings, changed its carotid endarterectomy (CEA) protocol to shunt cases based CoW assessment selectively. The aim this study is evaluate the effectiveness new selective shunting reducing incidence perioperative events after CEA. We prospectively collected clinical data outcomes 1899...
The aim of this study was to evaluate the impact anatomical variations in Circle Willis (CoW) on immediate neurological events (INE) after carotid endarterectomy (CEA) without shunting patients with contralateral occlusion (CCO). This a single-center, retrospective study. Patient's demographic and clinical outcomes data were prospectively collected. CoW segments reviewed retrospectively. Between January 2013 May 2018, 2090 underwent CEA under general anaesthesia, CCO found 113 (5.4%)...