A5100452374- Gut microbiota and health
- Microbial Community Ecology and Physiology
- Wastewater Treatment and Nitrogen Removal
- Clostridium difficile and Clostridium perfringens research
- Genomics and Phylogenetic Studies
- Ginseng Biological Effects and Applications
- Diet and metabolism studies
- Cancer-related molecular mechanisms research
- Angiogenesis and VEGF in Cancer
- Constructed Wetlands for Wastewater Treatment
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Pancreatitis Pathology and Treatment
- Epigenetics and DNA Methylation
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Gastric Cancer Management and Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Research in Cotton Cultivation
- Pharmacological Effects of Natural Compounds
- Birth, Development, and Health
- Colorectal Cancer Treatments and Studies
- Soil Carbon and Nitrogen Dynamics
- TGF-β signaling in diseases
Anhui Mental Health Center
2025
Anhui Medical University
2025
Beijing Luhe Hospital Affiliated to Capital Medical University
2023-2025
Shanghai Jiao Tong University
2016-2025
Tianjin Medical University
2012-2025
Beijing Chao-Yang Hospital
2023-2024
Capital Medical University
2023-2024
Hunan Cancer Hospital
2024
Southwestern Medical Center
2024
Sichuan Agricultural University
2020-2024
The gut microbiota benefits humans via short-chain fatty acid (SCFA) production from carbohydrate fermentation, and deficiency in SCFA is associated with type 2 diabetes mellitus (T2DM). We conducted a randomized clinical study of specifically designed isoenergetic diets, together fecal shotgun metagenomics, to show that select group SCFA-producing strains was promoted by dietary fibers most other potential producers were either diminished or unchanged patients T2DM. When the fiber-promoted...
ABSTRACT Accumulating evidence implicates gut microbiota as promising targets for the treatment of type 2 diabetes mellitus (T2DM). With a randomized clinical trial, we tested hypothesis that alteration may be involved in alleviation T2DM with hyperlipidemia by metformin and specifically designed herbal formula (AMC). Four hundred fifty patients were randomly assigned to either metformin- or AMC-treated group. After 12 weeks treatment, 100 selected from each group assessed improvement. The...
Butyrate-producing bacteria (BPB) are potential probiotic candidates for inflammatory bowel diseases as they often depleted in the diseased gut microbiota. However, here we found that augmentation of a human-derived butyrate-producing strain, Anaerostipes hadrus BPB5, significantly aggravated colitis dextran sulphate sodium (DSS)-treated mice while exerted no detrimental effect healthy mice. We explored how interaction between BPB5 and microbiota may contribute to this differential impact on...
Chronic hepatitis B (CHB) is a global epidemic disease that results from virus (HBV) infection and may progress to severe liver failure, including fibrosis, cirrhosis hepatocellular carcinoma. Previous evidence has indicated the dysbiosis of gut microbiota occurs after associated with disease. The aim this study elucidate compositional functional characteristics in early-stage CHB understand their influence on progression. We investigated microbial composition stool samples 85 patients low...
Capsaicin reduces body weight mainly through activation of transient receptor potential vanilloid 1 (TRPV1) cation channel. However, recent evidence indicates that the gut microbiota influences many physiological processes in host and might provoke obesity. This study determined whether anti-obesity effect capsaicin is related to changes microbiota. C57BL/6 mice were fed either with high-fat diet (HFD) or HFD (HFD-CAP) for nine weeks. We observed a significantly reduced gain improved glucose...
Obesity is associated with a high prevalence of mood disorders such as anxiety and depression. Both stress fat diet can alter the gut microbiota contribute to obesity. To examine interrelationships between obesity, stress, disorders, obesity was induced in mice using diet, were subsequently stressed chronic unpredictable mild protocol. During experiment, composition analyzed by 16 S rRNA gene high-throughput sequencing, anxiety-like behaviors measured. The results revealed distinct gender...
Abstract Gut microbiota dysbiosis has a significant role in the pathogenesis of metabolic diseases, including obesity. Nuciferine (NUC) is main bioactive component lotus leaf that been used as food China since ancient times. Here, we examined whether anti-obesity effects NUC are related to modulations gut microbiota. Using an obese rat model fed HFD for 8 weeks, show supplementation rats prevents weight gain, reduces fat accumulation, and ameliorates lipid disorders. Furthermore, 16S rRNA...
Archaeal methanogenesis is a dynamic process regulated by various cellular and environmental signals. However, understanding this regulation technically challenging due to the difficulty of measuring gene expression dynamics in individual archaeal cells. Here, we develop multi-round hybridization chain reaction (HCR)-assisted single-molecule fluorescence situ (FISH) method quantify transcriptional 12 genes involved cells Methanococcoides orientis. Under optimal growth condition, most these...
Abstract The mechanism by which nanoparticles cross the placental barrier was studied using isotopic tracers. abortion rates and other related data were counted analysed in pregnant mice with different pregnancy times. Results showed that oxidised multi-walled carbon nanotubes (oMWCNTs) crossed entered foetus body. depended on first-time, second-time fourth-time 70%, 40% 50%, respectively. maternal body weight gain inhibited until gestational ages of 13, 10 11 d. oMWCNTs decreased serum...
Previous studies have shown an association between coiled-coil domain-containing (CCDC) genes and different cancers. Our previous revealed that CCDC43 is highly expressed in colorectal cancer, but the expression molecular mechanisms of gastric cancer (GC) are yet to be determined. Here, we show overexpressed tissues. closely related tumor differentiation, lymph-node-metastasis, prognosis cancer. Overexpression promotes proliferation, invasion, metastasis GC cells. may upregulate stabilize...
Abstract Background Reproducible detection of inherited variants with whole genome sequencing (WGS) is vital for the implementation precision medicine and a complicated process in which each step affects variant call quality. Systematically assessing reproducibility WGS impact needed understanding improving quality from WGS. Results To dissect factors involved WGS, we sequence triplicates eight DNA samples representing two populations on three short-read platforms using library kits six labs...
In this article, sequence analysis of the coding region (5S) and adjacent nontranscribed spacer (NTS) were conducted in red crucian carp (RCC), blunt snout bream (BSB), their polyploid offspring. Three monomeric 5S rDNA classes (designated class I: 203 bp; II: 340 III: 477 bp) RCC characterized by distinct NTS types NTS-I, II, III for 83, 220, 357 bp monomers, respectively). BSB, only one was observed IV: 188 bp), which type NTS-IV: 68 bp). offspring, tetraploid (4nRB) hybrids partially...
Abstract Gnotobiotic mouse model is generally used to evaluate the efficacy of gut microbiota. Sex differences microbiota are acknowledged, yet effect recipient’s gender on bacterial colonization remains unclear. Here we inoculated male and female germ-free C57BL/6J mice with fecal bacteria from a man short-term vegetarian inulin-supplemented diet. We sequenced 16S rRNA genes V3-V4 region donor’s feces colonic content. Shannon diversity index showed recipients have higher than males....
Smaller size and trichomes favored higher accumulation of PS MNPs on the leaf epidermis, while nanoscale entered vasculature via apoplastic symplastic pathways.
The gut microbiome represents an important reservoir of antibiotic resistance genes (ARGs). Effective methods are urgently needed for managing the resistome to fight against threat. In this study, we show that a microbiota-targeted dietary intervention, which shifts dominant fermentation bacteria from protein carbohydrate, significantly diminished and alleviated metabolic syndrome in obese children. Of non-redundant metagenomic gene catalog ~2 × 10(6) microbial genes, 399 ARGs were...
Quinoline is biodegradable under anaerobic conditions, but information about the degradation kinetics and involved microorganisms scarce. Here, dynamics of a quinoline-degrading bacterial consortium were studied in anoxic batch cultures containing nitrate. The removed 83.5% quinoline during first 80 hours, which dominated by denitrification, then switched to methanogenesis when nitrogen oxyanions depleted. Time-resolved community analysis using pyrosequencing revealed that denitrifiying...
Background: The melastatin-related transient receptor potential 7 channel (TRPM7) is a nonselective cation that has been shown to promote tumor metastasis and progression. In this study, we determined the expression of TRPM7 in ovarian carcinomas investigated its possible prognostic value. Materials Methods: Samples were collected from 138 patients with cancer. Expression was assessed by real-time PCR immunohistochemistry, expressed reference an established scoring system related clinical...