A5019000150- Metal complexes synthesis and properties
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Trace Elements in Health
- Crystallography and molecular interactions
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Advanced biosensing and bioanalysis techniques
- Advanced Nanomaterials in Catalysis
- Gold and Silver Nanoparticles Synthesis and Applications
- Protein Interaction Studies and Fluorescence Analysis
- Computational Drug Discovery Methods
- CRISPR and Genetic Engineering
- Ferrocene Chemistry and Applications
- Biosensors and Analytical Detection
- Nanoparticles: synthesis and applications
- Nanocluster Synthesis and Applications
- Organometallic Compounds Synthesis and Characterization
- Corrosion Behavior and Inhibition
- Innovation and Socioeconomic Development
- Metal-Organic Frameworks: Synthesis and Applications
- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Animal Virus Infections Studies
University of Massachusetts Amherst
2014-2023
The University of Texas at Austin
2019
University of Florence
2011-2018
Amherst College
2018
Uncontrolled inflammation is responsible for acute and chronic diseases in the lung. Regulating expression of pro-inflammatory genes pulmonary tissue using small interfering RNA (siRNA) a promising approach to combatting respiratory diseases. However, siRNA therapeutics are generally hindered at cellular level by endosomal entrapment delivered cargo organismal inefficient localization tissue. Here we report efficient anti-inflammatory activity vitro vivo polyplexes an engineered cationic...
Two novel gold carbene compounds, namely, chlorido (1-butyl-3-methyl-imidazole-2-ylidene) gold(I) (1) and bis(1-butyl-3-methyl-imidazole-2-ylidene) (2), were prepared characterized as prospective anticancer drug candidates. These compounds consist of a center linearly coordinated either to one N-heterocyclic (NHC) chloride ligand or two identical NHC ligands (2). Crystal structures solved for both the resulting structural data being in good agreement with expectations. We wondered whether...
The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug–protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds inherent protein metalation processes.
Clinical translation of photoacoustic imaging (PAI) has been limited by the lack near-infrared (NIR) contrast agents with low toxicity required for regulatory approval. Herein, J aggregates indocyanine green (ICG) strong NIR absorbance were encapsulated at high loadings within small 77 nm polymersomes (nanocapsules) composed poly(lactide-co-glycolide-b-poly(ethylene glycol)) (PLGA-b-PEG) bilayers, thus enabling PAI breast and ovarian cancer cells specificity a sensitivity level ∼100 total...
A high-resolution CE-ICP-MS method is presented for monitoring and comprehensive understanding of the protein-mediated transformations gold nanoparticles in human serum.
The reaction of Auoxo6, a dinuclear gold(iii) complex, with the model protein bovine pancreatic ribonuclease is explored here by X-ray diffraction and ESI mass spectrometry. Data provide clues on processes adduct formation enzyme inhibition and, inductively, likely mode action this metallodrug.
The interactions with proteins, cytotoxicity and blood compatibility of PEGylated gold nanorods are reviewed as a function particle size.
Picking a fight with parasites! Trypanothione reductase (TR) is validated drug target for the development of antileishmanial agents. A group structurally diverse gold-containing compounds was evaluated in vitro TR inhibition. number exhibited potent activity and deserve further pharmacological evaluation.
The anticancer ruthenium(<sc>iii</sc>) complex NAMI-A induces potent and unexpected cytotoxic effects in leukaemia cells causing selective inhibition of KCa 3.1 channels.
Small gold nanorods (GNRs) with longitudinal plasmon absorption in the near-infrared window (700-900 nm), are of great interest for vivo optical applications (e.g., photothermal therapy) and their high-payload-to-carrier ratio drug delivery. Common synthetic strategies GNR production afford spherical cubical nanoparticles addition to desired GNRS. Thus, several methods have been proposed selective separation GNRs from reaction byproducts. For example, centrifugation has used separate high...
The reaction of [Ru(CO)6Cl2], 1, with N[combining low line]3-methylbenzimidazole (MBI) and 5,6-dimethylbenzimidazole (DMBI) afforded two new complexes the general formula fac-[RuII(CO)3Cl2L], L = MBI (2) or DMBI (4). Crystals cis,trans-[RuII(CO)2Cl2(N[combining line]3-MBI)2], 3, were also obtained from mother liquor that produced 2. In presence water, dissociation Ru-N, Ru-Cl Ru-CO bonds occurred as a function time, water content pH. Density functional theory structure...
Based on ESI-MS measurements, we show here that some representative cytotoxic gold(III) compounds produce stable adducts upon reaction with the copper chaperone Atox-1; notably, such contain gold in oxidation state +1. These findings are of interest to understand intracellular metabolism medicinal species and develop new potent inhibitors trafficking system.