A5107831240- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Acute Ischemic Stroke Management
- Coronary Interventions and Diagnostics
- Intracranial Aneurysms: Treatment and Complications
- Cardiac Imaging and Diagnostics
- Health Systems, Economic Evaluations, Quality of Life
- Lipoproteins and Cardiovascular Health
- Cardiac Valve Diseases and Treatments
- Dialysis and Renal Disease Management
- Optical Coherence Tomography Applications
- Peripheral Artery Disease Management
- Oropharyngeal Anatomy and Pathologies
- Dementia and Cognitive Impairment Research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Infective Endocarditis Diagnosis and Management
- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Iron Metabolism and Disorders
- Renal function and acid-base balance
- Healthcare cost, quality, practices
- Cardiac, Anesthesia and Surgical Outcomes
- Advanced MRI Techniques and Applications
- RNA and protein synthesis mechanisms
- Pelvic and Acetabular Injuries
Baptist Memorial Hospital
2005-2025
Central Baptist Hospital
2012-2021
Baxter (United States)
1997-2015
Daiichi Sankyo (United States)
2010-2014
Vaccine & Gene Therapy Institute of Florida
2014
Resnick Sustainability Institute
2011
University of California, Los Angeles
2011
National Institutes of Health
2005
University of North Carolina at Chapel Hill
2001
Duke University
2001
ILUMIEN I is the largest prospective, non-randomized, observational study of percutaneous coronary intervention (PCI) procedural practice in patients undergoing intra-procedural pre- and post-PCI fractional flow reserve (FFR) optical coherence tomography (OCT). We report on impact OCT physician decision-making association with FFR values early clinical events.Optical documentary were performed 418 (with 467 stenoses) stable or unstable angina NSTEMI. Based pre-PCI OCT, procedure was altered...
We sought to improve the reliability of Trial ORG 10172 in Acute Stroke Treatment (TOAST) classification stroke subtype for retrospective use clinical, health services, and quality care outcome studies. The TOAST investigators devised a series 11 definitions classify patients with ischemic into 5 major etiologic/pathophysiological groupings. Interrater agreement was reported be substantial who were independently assessed by pairs physicians. However, cautioned that disagreements assignment...
Carotid endarterectomy and carotid artery stenting are the leading approaches to revascularization for stenosis, yet contemporary data on trends in rates outcomes limited.To describe US national performance of among Medicare beneficiaries from 1999 2014.Serial cross-sectional analysis fee-for-service aged 65 years or older 2014 using Inpatient Denominator files. Spatial mixed models adjusted age, sex, race were fit calculate county-specific risk-standardized rates. Mixed assess after...
Optical coherence tomography (OCT) has emerged as an essential tool in coronary atherosclerosis research and shown clinical value optimizing percutaneous intervention. Its capability to identify plaque pathology accurately detect intervention results, often overlooked by angiography, serves a guide managing patients with acute syndromes, myocardial infarction due nonobstructing artery disease, calcified arteries, in-stent restenosis, thus contributing improved outcomes. However, the current...
Background and Purpose: Studies of carotid artery disease have suggested that high-grade stenosis can affect cognition, even without stroke. The presence degree cognitive impairment in such patients not been reported compared with a demographically matched population-based cohort. Methods: We studied cognition 1000 consecutive CREST-2 (Carotid Revascularization Medical Management for Asymptomatic Carotid Stenosis Trial) patients, treatment trial asymptomatic disease. Cognitive assessment was...
This study evaluated the effect of colesevelam hydrochloride on insulin sensitivity, potential binding to glucose, and chronic effect(s) fasting postprandial glucose in patients with type 2 diabetes mellitus.Patients meeting inclusion criteria were withdrawn from all antidiabetes agents for weeks randomized 3.75 grams/day (n = 17) or placebo 18) 8 weeks. Hyperinsulinemic-euglycemic clamp studies performed at baseline (week -1) 8. A meal tolerance test was conducted -1, 0, 2, The drug...
Background and Purpose: The CREST2 trial (Carotid Revascularization Medical Management for Asymptomatic Carotid Stenosis) is comparing intensive medical management (IMM) alone to IMM plus revascularization with carotid endarterectomy or transfemoral artery stenting preventing stroke death within 44 days after randomization ipsilateral ischemic thereafter. There are extensive clinical data on outcomes of asymptomatic stenosis, but not IMM. As such, the experimental treatment in IMM, which...
Objective Losses of nutrients into dialysate may contribute to malnutrition. Peritoneal dialysis (PD) patients are reported lose 3 -4 g/day amino acids (AAs) and 4 -15 proteins. The extent which one exchange with a 1.1% AA solution (Nutrineal, Baxter, Deerfield, IL, U.s.A.) offsets these losses was investigated in 3-day inpatient study 20 PD patients. Design Simple, open-label, cross-over on consecutive days clinical research unit. On day 1 all were given peritoneal equilibration test (PET)....
Carotid artery-related stroke is largely an embolic disease that has been correlated with inflammation, plaque rupture, and thrombus formation in "vulnerable" atherosclerotic plaque. Nevertheless, current guidelines for carotid revascularization asymptomatic patients rely on the calculation of stenosis risk assessment, a parameter viewed increasing skepticism. Intravascular OCT imaging technique offers high axial resolution (10 μm), allowing unprecedented micron-level assessment human...
Identifying subjects with mild cognitive impairment (MCI) most likely to decline in cognition over time is a major focus Alzheimer′s disease (AD) research. Neuroimaging biomarkers that predict would have great potential for increasing the efficacy of early intervention. In this study, we used high‐resolution MRI, combined cortical unfolding technique increase visibility convoluted medial temporal lobe (MTL), assess whether gray matter thickness MCI correlated two years. We found entorhinal...
The Carotid Revascularization Endarterectomy versus Stenting Trial (CREST) previously reported increased mortality in patients who sustained a periprocedural stroke or cardiac event (myocardial infarction [MI] biomarker only) follow-up to 4 years. We now extend these observations 10
To examine regional wall acceleration and its relation to relaxation.8 sheep were examined by tissue Doppler ultrasound imaging (VingMed Vivid FiVe) in apical four chamber views evaluate the left ventricular divided into six segments mitral annulus two segments. Peak myocardial during isovolumic periods (pIVA) derived from echocardiography was analysed contraction (ICT) relaxation times (IRT) each segment.After scanning at baseline, haemodynamic status changed administration of blood,...