A5101958014- Viral Infections and Vectors
- Viral Infections and Outbreaks Research
- Mosquito-borne diseases and control
- Fire effects on ecosystems
- Cancer-related molecular mechanisms research
- interferon and immune responses
- RNA and protein synthesis mechanisms
- Vector-Borne Animal Diseases
- Bacteriophages and microbial interactions
- Plant Molecular Biology Research
- Extracellular vesicles in disease
- Metal complexes synthesis and properties
- Immune responses and vaccinations
- Bacterial Genetics and Biotechnology
- Liver Disease Diagnosis and Treatment
- Neuroinflammation and Neurodegeneration Mechanisms
- Lanthanide and Transition Metal Complexes
- MicroRNA in disease regulation
- RNA regulation and disease
- Pancreatitis Pathology and Treatment
- Recycled Aggregate Concrete Performance
- Adenosine and Purinergic Signaling
- Luminescence and Fluorescent Materials
- Plant Surface Properties and Treatments
- Liver physiology and pathology
Chongqing University
2025
Jinan University
2025
South China University of Technology
2025
Air Force Medical University
2016-2024
Tang Du Hospital
2018-2024
Xi'an Medical University
2023
Beijing Forestry University
2019-2021
Xijing Hospital
2021
University of Hong Kong
2020
Beijing Academy of Agricultural and Forestry Sciences
2019
Hantavirus infection, which causes zoonotic diseases with a high mortality rate in humans, has long been global public health concern. Over the past decades, accumulating evidence suggests that noncoding RNAs (lncRNAs) play key regulatory roles innate immunity. However, involvement of host lncRNAs hantaviral control remains uncharacterized. In this study, we identified lncRNA NEAT1 as vital antiviral modulator. was dramatically upregulated after Hantaan virus (HTNV) whereas its...
Hantaan virus (HTNV) causes hemorrhagic fever with renal syndrome (HFRS). Previous studies have identified interferon-induced transmembrane proteins (IFITMs) as an interferon-stimulated gene family. However, the role of IFITMs in HTNV infection is unclear. In this study, we observed that IFITM3 single nucleotide polymorphisms (SNP) rs12252 C allele and CC genotype associated disease severity load plasma HFRS patients. vitro experiments showed truncated protein produced by exhibited impaired...
Abstract Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly pathogenic human causing severe disease and mortality. MERS-CoV infection failed to elicit robust IFN response, suggesting that the virus might have evolved strategies evade host innate immune surveillance. In this study, we identified characterized type I antagonism of open reading frame (ORF) 8b accessory protein. ORF8b was abundantly expressed in MERS-CoV–infected Huh-7 cells. When ectopically expressed,...
Japanese encephalitis virus (JEV) is the most prevalent cause of viral in Asia and western Pacific. Neuronal death caused by JEV infection inflammation induced cytotoxicity leads to progression deterioration (JE). Mixed-lineage kinase domain-like protein (MLKL) mediated necroptosis a newly discovered pathway programmed cell participates many inflammatory diseases. In this study, we demonstrated for first time that was involved neuronal loss during JE via immune-electron microscopy...
Pericarp wax of cucumber is an important economic trait, determining sales and marketing. Grafting onto pumpkin rootstock (Cucurbita moschata) effective way to produce glossy fruits. However, the molecular regulation mechanism this phenomenon remains largely unknown. In present study, transcriptome analyses, genome-wide DNA methylation sequencing, metabolite analysis were performed on pericarp self-rooted versus grafted cucumber. We identified AP2/ERF-type transcription factor CsWIN1 as...
Japanese encephalitis virus (JEV) is the leading cause of viral in Asia. (JE) caused by JEV characterized extensive inflammatory cytokine secretion, microglia activation, blood-brain barrier (BBB) breakdown, and neuronal death, all which contribute to vicious cycle damage. There are currently no effective treatments for JE. Mesenchymal stem cells (MSCs) have been demonstrated a therapeutic effect on many central nervous system (CNS) diseases regulating inflammation other mechanisms. In vivo,...
Japanese encephalitis virus (JEV), the leading cause of viral in Asia, is neurovirulent and neuroinvasive. Neurons are main target JEV infection propagation. Receptor interacting serine/threonine-protein kinase 3 (RIPK3) has been reported to contribute neuroinflammation neuronal death many central nervous system diseases. In this study, we found that progression JE was alleviated RIPK3-knockout (RIPK3-/-) mice both peripheral intracerebral infection. RIPK3-knockdown (RIPK3-RNAi) neuro2a...
Site selection is the key to carrying out industrial layout of construction and demolition waste (CDW) resourcing enterprises. The current study needs more data on CDW industry location. resource utilization rate need be improved. This uses statistical visualization methods analyze factors affecting location recycling Additionally, it identifies planning strategies policy incentives drive development. explicitly adopts global weighted geographic regression (GWR) analysis ArcGIS 10.8...
Severe fever with thrombocytopenia syndrome virus (SFTSV) has been prevalent for some time in China and it was first identified 2010. However, the seroprevalence of SFTSV general population southeastern risk factors associated infection are currently unclear. Blood samples were collected from seven counties across Zhejiang province tested presence SFTSV-specific IgG antibodies by ELISA. A total 1380 blood which 5·51% seropositive varying significantly between sites. Seroprevalence people who...
As the global prototypical zoonotic hantavirus, Hantaan virus (HTNV) is prevalent in Asia and leading causative agent of severe hemorrhagic fever with renal syndrome (HFRS), which has profound morbidity mortality. Macrophages are crucial components host innate immune system serve as first line defense against HTNV infection. Previous studies indicated that viral replication efficiency macrophages determines hantavirus pathogenicity, but it remains unknown factor manipulates macrophage...
Abstract This study was designed to investigate the effect of U50,488H (a selective κ-opioid receptor agonist) on endothelial function impaired by hyperlipidemia and determine role Akt-stimulated NO production in it. Hyperlipidemic model established feeding rats with a high-fat diet for 14 weeks. nor-BNI antagonist) were administered intraperitoneally. In vitro , involvement PI3K/Akt/eNOS pathway studied using cultured cells subjected artificial hyperlipidemia. Serum total cholesterol...
Phenotypic plasticity enables individuals to develop different phenotypes in a changing environment and promotes adaptive evolution. Genome-wide association study (GWAS) facilitates the of genetic basis bacterial phenotypes, provides new opportunity for phenotypic research. To investigate relationship between growth genotype bacteria, 41 Staphylococcus aureus strains, including 29 vancomycin-intermediate S. (VISA) were inoculated absence or presence vancomycin 48 h. Growth curves maximum...
Hepatitis C virus (HCV) dysregulates innate and adaptive immune responses while monocytes (M) play a crucial role in linking immunity to control viral infection. A transcription factor T-bet is upregulated dampen M functions via the c-Jun N-terminal kinase (JNK) pathway, followed by enhanced Tim-3 expression chronic HCV However, molecular mechanisms that are yet unknown. miR-155 has been implicated as key regulator controlling diverse biological processes through posttranscriptional...
Hantaan virus (HTNV) infections can cause severe hemorrhagic fever with renal syndrome (HFRS) in humans, which is associated high fatality rates. Cytotoxic T lymphocyte (CTL) responses contribute to elimination; however, date, HLA class Ⅰ allele-restricted HTNV glycoprotein (GP) epitopes recognized by CTLs have not been reported, limiting our understanding of CTL against infection humans. In this study, 34 GP nine-mer that may bind HLA-A*0201 molecules were predicted using the BIMAS and...
To develop and validate a simple effective death risk stratification scale for hemorrhagic fever with renal syndrome (HFRS).
Background Japanese encephalitis virus (JEV) is the main cause of viral in Asia. Nowadays, no effective and specific therapy for JE patients available except supportive treatment. The fatality rate still about 30%, more than half survivors suffered from various neuropsychiatric sequelae. Thus, attention should be paid to JE. Methods In this study, a retrospective cohort was collected general features admitted into Department Infectious Diseases were analyzed. Meanwhile, dynamic change plasma...
Foliage diseases are prevalent in cucumber production and cause serious yield reduction across the world. Identifying resistance or susceptible genes under foliage-disease stress is essential for breeding resistant varieties, of which leaf-specific expressed extremely important but rarely studied crops. This study performed an in-depth mining public transcriptome data both different tissues downy mildew (DM) inoculation, found that expression transcription factor CsTCP14 was significantly...
Seedling overgrowth always develops in undernourished plants due to biotic or abiotic stresses, which significantly decrease the yield of crops and vegetables. It is known that plant growth retardants paclobutrazol (PBZ) chlormequat chloride (CCC) are most commonly used chemicals controlling seedling height by regulating gibberellin (GA) biosynthesis pathway. However, exact molecular regulation mechanism remains largely unknown. This study performed a comprehensive transcriptome profile...