A5101941135- Hepatitis C virus research
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- Acupuncture Treatment Research Studies
- Translation Studies and Practices
- Botulinum Toxin and Related Neurological Disorders
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Psoriasis: Treatment and Pathogenesis
- Hematopoietic Stem Cell Transplantation
- Non-Invasive Vital Sign Monitoring
- Saffron Plant Research Studies
- Flavonoids in Medical Research
- Spinal Cord Injury Research
- Mesenchymal stem cell research
- Mosquito-borne diseases and control
- Cardiovascular Disease and Adiposity
- Blood donation and transfusion practices
- Digital Storytelling and Education
- Ocular Surface and Contact Lens
- Multiple Myeloma Research and Treatments
- Respiratory viral infections research
The Affiliated Yongchuan Hospital of Chongqing Medical University
2025
Chongqing Medical University
2025
Roche (China)
2025
Institute of Hydrobiology
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
China-Japan Friendship Hospital
2020-2024
Taihe Hospital
2024
Hubei University of Medicine
2024
We investigated the migration patterns of hepatitis C virus (HCV) in China. Partial E1 and/or NS5B sequences from 411 volunteer blood donors sampled 17 provinces and municipalities located five large regions, north-northeast, northwest, southwest, central south, southeast, were characterized. The classified into eight subtypes (1a, n = 3; 1b, 183; 2a, 83; 3a, 30; 3b, 44; 6a, 55; 6n, 10; 6v, 1) a new subtype candidate. Bayesian evolutionary analysis by sampling trees major revealed distinct...
Psoriasis is a common chronic immune-inflammatory disease. Challenges exist in the present treatment of psoriasis, such as difficulties transdermal drug administration and severe side effects. We hope to achieve better therapeutic outcome for psoriasis treatment. By using modified soluble microneedles (MNs) loaded with daphnetin, symptoms mice, abnormal proliferation keratinocytes, secretion inflammatory factors were significantly reduced. In vitro, daphnetin proven inhibit NF-κB signaling...
Advanced nursing practice and education with a Master's degree as the necessary preparation, is viewed major strategy to cultivate senior talents. Competencies are central advanced education, but how can competencies be measured? Entrustable professional activities (EPAs) have been used widely in medicine practical approach for bridging gaps between competency clinical practice. Considering paucity of research EPAs graduates China, it needed develop specifically Chinese Master Nursing...
Different hepatitis C virus (HCV) genotypes exhibit differences in disease pathogenesis and progression, as well outcomes response to therapy. Tracking the change of HCV various epidemiological settings is critical for both surveillance development improved antiviral treatment. Here, we tracked changes prevalence China between 2004-2007 2008-2011. HCV-RNA-positive sera were collected from volunteer blood donors during period The determined by phylogenic analysis using NS5B E1 sequences....
PKMYT1 is a crucial regulator of the cell cycle, particularly involved in G2/M transition through inhibitory phosphorylation CDK1, and promising therapeutic target for cancer therapy. Data mining Roche kinome screen database identified hit characterized by 100% activity at 10 μM concentration, which was further validated with enzymatic assay showing double-digit nanomolar potency. The featured quinolinone central core phenol headgroup. replacement problematic headgroup an indazole moiety...
Abstract Spontaneous clearance of hepatitis C virus (HCV) occurs in 10–40% the infections. Specific human leukocyte antigen (HLA) alleles have been identified associating with HCV clearance. However, data on association HLA spontaneous are scarce Chinese population. In current study we studied class I and II genes 231 voluntary blood donors who had cleared infection spontaneously compared to 429 subjects chronic We also their IL28B SNP (rs8099917) genotype, since a number investigators found...
Background Both HCV genotypes and viral loads are predictors of therapeutic outcomes among patients treated with α-interferon plus ribavirin; however, such correlation has only been studied for 1, 2, 3 but not genotype 6. Methodology/Findings 299 voluntary blood donors were recruited who viremic. Their mean age was 31.8; the male/female ratio 3.82 (225/59). The measured using COBAS AmpliPrep/COBAS TaqMan test (CAP/CTM) while determined by direct sequencing partial NS5B region. 3, 6 in 48.9%,...
In 2014, an outbreak of dengue virus (DENV) infection led to 45 171 clinical cases diagnosed in Guangdong province, Southern China. However, the potential risk blood donors asymptomatically infected with DENV has not been evaluated . current study we detected anti-DENV IgG antibody and RNA volunteer Chinese donors. We found that was positively 3.4% (51/1500) two were as being positive out 3000 samples. concluded presence might be for safety. Therefore, screening should considered donations...
BACKGROUND Natural killer (NK) cells are critical components in innate immune response to viral infection. Killer cell immunoglobulin‐like receptors (KIRs) involved regulating the balance of activation or inhibitory function NK cells. However, association KIRs with spontaneous clearance hepatitis C virus (HCV) remains unclear Chinese population. STUDY DESIGN AND METHODS A total 407 HCV‐seropositive voluntary blood donors were recruited, including 203 and 204 chronic The presence KIR genes...
<b><i>Background:</i></b> Although human leukocyte antigens (HLA) have been shown in association with the outcomes of hepatitis C virus (HCV) infection among different ethnic groups, such studies remain absent China, where HCV prevalence is higher than global average. <b><i>Methods:</i></b> In this study, 426 HCV-infected and 709 uninfected blood donors were analyzed, whom HLA alleles sequenced using a high-resolution genotyping method....
Abstract Specific human leukocyte antigen (HLA) class I and II alleles have been associated with spontaneous clearance or persistent infection of hepatitis C virus (HCV), which seemed to be restricted by the host's ethnicity viral genotype. Recently we reported a high prevalence rate HCV in cohort Chinese Li who were infected new variants genotype 6. In this study, found that distribution HLA individuals (n = 143) was distinct from Han our previous study. HLA‐DRB1*11:01 DQB1*03:01 more...
Non‑SMC condensin I complex subunit D2 (
The rapid development of scaffold-based bone tissue engineering strongly relies on the fabrication advanced scaffolds and use newly discovered functional drugs. As creation new drugs their clinical approval often cost a long time billions U.S. dollars, producing loaded with repositioned conventional whose biosafety has been verified clinically to treat critical-sized defect gained increasing attention. Carfilzomib (CFZ), an approved proteasome inhibitor much fewer side effects, is used...
The epidemiology of hepatitis C virus varies widely across geographical regions and ethnic groups. Our previous study showed that 6 strains isolated from Baisha County, Hainan Island, China, were all new genotype (gt6) subtypes which differed significantly other regions. In the current study, we conducted a comprehensive epidemiological survey HCV in Li group, native to County. Anti-HCV antibodies detected by 2 independent ELISAs participants, positive results confirmed recombinant...
Nutrition is the major source of bioenergy. The present study investigated physiological response to fasting by analyzing effect on pulse spectrum radial artery. Sixteen subjects were allowed take only mineral water for 24 hours, and was measured at intervals during after eating resumed. Data analyzed using one-way analysis variance (ANOVA) with Scheffe's test pairwise comparisons. results indicate second harmonic increased sixth decreased significantly hours fasting. proportions then those...
The published evidence on the effectiveness and safety of acupuncture people with dementia has been inconsistent. This systematic review overviews aims to summarize evaluate from relevant reviews (SRs) meta-analyses provide reliable for future clinical treatment. We searched PubMed, EMBASE, Web Science, Cochrane Library, Database Systematic Reviews, DARE, Google Scholar, CNKI, VIP, CBM Wangfang establishment databases January 2020. types based pathology mainly include Alzheimer's disease...