A5101458968- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Cancer, Lipids, and Metabolism
- Inhalation and Respiratory Drug Delivery
- Occupational and environmental lung diseases
- Veterinary Oncology Research
- Metabolism, Diabetes, and Cancer
- Cancer Cells and Metastasis
- Advanced Drug Delivery Systems
- Infectious Diseases and Mycology
- Genetic factors in colorectal cancer
- Veterinary Medicine and Surgery
- Synthetic Organic Chemistry Methods
- Pancreatic and Hepatic Oncology Research
- Vitamin D Research Studies
- Epigenetics and DNA Methylation
- Traditional and Medicinal Uses of Annonaceae
- Radical Photochemical Reactions
- Agriculture, Soil, Plant Science
- Occupational exposure and asthma
- Microwave and Dielectric Measurement Techniques
- Cancer-related Molecular Pathways
- Herbal Medicine Research Studies
- Energy and Environmental Systems
- Chemokine receptors and signaling
Seoul National University Bundang Hospital
2022-2025
Seoul National University
2005-2024
Seoul Institute
2017
Dong-A University
2015-2016
Instillation of highly soluble nanoparticles (NPs) into the lungs rodents can cause acute eosinophilia without any previous sensitizations by role dissolved ions. However, whether gradually dissolving NPs same type remains to be elucidated. We selected nickel oxide (NiO) as a NP and evaluated time course pulmonary inflammation pattern well its mechanisms. NiO were intratracheally instilled female Wistar rats at various concentrations (50, 100, 200 cm2/rat) lung was time-points (1, 2, 3, 4...
Hypoxia is a hallmark of the solid tumor microenvironment and associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying hypoxia-induced phenotypic changes using human malignant mesothelioma (HMM) cells. Hypoxic conditions were achieved by incubating HMM cells air chamber. effect hypoxia on phenotype investigated performing vitro clonogenicity, drug resistance, migration, invasion assays. Signaling pathways molecules involved more...
Chemokines and their receptors play integral roles in carcinogenesis. CXC motif chemokine receptor 3 (CXCR3) T cells mediates anti-tumor effects, whereas CXCR3 malignant promotes proliferation metastasis. Although the role of has been well-documented human cancers, including breast cancer, its function canine tumors remains largely unexplored. This study aimed to investigate effects ligand interaction mammary gland tumor (cMGT) cells. expression two cMGT cell lines, CIPp CIPm, was evaluated...
This study compared plasma cell-free DNA (cfDNA) and tumor tissue (ttDNA) to explore the clinical applicability of cfDNA in patients with metastatic gastric cancer (mGC) receiving palliative second-line paclitaxel + ramucirumab treatment. Targeted sequencing 106 genes was conducted using germline at baseline (baseline-cfDNA) progressive disease (PD-cfDNA). The results were those ttDNA-based panel data. Of 76 consecutive patients, 46 (27 males; median age 57.5 [range, 32-73] years) who had...
Abstract Simultaneously targeting HER2 and HER3 pathways is a potentially effective strategy for treating patients with HER2-positive gastric cancer (GC). A recent significant advancement in targeted therapy GC the development of trastuzumab deruxtecan (T-DXd). However, co-administration blockade T-DXd to has not yet been explored, making this pioneering study. Our vitro analysis showed that cell growth inhibitory effect on cells resembled antiproliferative pattern induced by trastuzumab,...
Abstract COP9 Signalosome Subunit 5 (COPS5), a deubiquitinating enzyme, contributes to chemoresistance, and its expression is closely correlated with poor prognosis in patients solid tumors. However, the role of COPS5 amplification gastric cancer (GC) inhibition HER2-amplified GC models has never been elucidated. In curated stomach adenocarcinoma cohort (n=294) from The Cancer Genome Atlas datasets, significantly co-occurred HER2 (10.5% vs. 2.7%, P=0.040) was associated worse disease-free...
Cancer-associated fibroblasts (CAFs) coordinate the malignancy of cancer cells via secretory materials. Reprogrammed lipid metabolism and signaling play critical roles in biology. Oleic acid (OA) serves as a source energy under glucose-deficient conditions, but its function progression remains unclear. The present study investigated that CAFs xenografted tumors had higher amounts fatty acids, particularly OA, compared to normal fibroblasts, promoted cell stemness lung adenocarcinoma...
Safe and efficient drug delivery systems have received great attention for cancer therapy due to their enhanced cancer-targeting efficiency reduced undesirable side effects.
Metformin, a drug for type 2 diabetes mellitus, has shown therapeutic effects various cancers. However, it had no beneficial on the survival rate of human malignant mesothelioma ( HMM ) patients. The present study was performed to elucidate underlying mechanism metformin resistance in cells. Glucose‐starved cells enhanced metformin, demonstrated by decreased apoptosis and autophagy increased cell survival. These showed abnormalities mitochondria, such as ATP synthesis, morphological...
This study aimed to compare tumor tissue DNA (ttDNA) and circulating (ctDNA) explore the clinical applicability of ctDNA better understand clonal evolution in patients with metastatic colorectal cancer undergoing palliative first-line systemic therapy.
The potyvirus coat protein (CP) is involved in aphid transmission, cell-to-cell movement and virus assembly, not only by binding to viral RNA, but also self-interaction or interactions with other factors. In this study, a number of CP mutants Soybean mosaic (SMV) containing deletions site-directed mutations were generated cloned into yeast two-hybrid vectors. Interaction was confirmed the expression reporter genes, including HIS3, ADE2 MEL1, strain AH109. Deletion C-terminal region caused...
Knowledge that links the physicochemical properties of nanoparticles (NP) to their toxicity is key evaluating and understanding mechanisms underlying developing appropriate testing methods for NP; however, this currently limited since only a small set NP have been used, with typically poor control physical properties. In study, eight types polystyrene (PLNP) were synthesized different functional groups, but all based on an identical core. vitro cell-based assays performed determine influence...
Glycated hemoglobin A1c (HbA1c) is widely used for monitoring and diagnosing human diabetes mellitus, but rarely in veterinary clinics. The goal of our study was to validate the commercial HbA1c testing system SD A1cCare analyzer (Bionote, Gyeoggi-do, South Korea) use dogs. Dogs were recruited with owner's consent. Diabetic status determined based on clinical signs, fasting hyperglycemia, glycosuria. Intra-assay precision linearity evaluated EDTA, heparin, or citrate as anticoagulants, had...
Tumor hypoxia is known to promote the acquisition of more aggressive phenotypes in human transitional cell carcinoma (TCC), including drug resistance. Accumulating evidence suggests that mitochondria play a central role chemoresistance TCC. However, hypoxia-induced resistance TCC remains elusive. The present study investigated function using line under hypoxic conditions. In vitro (0.1% O2, 48 h) was achieved by incubating cells air chamber. Mitochondrial events involving were assessed....
The convergent synthesis of a fully elaborated C13–C27 fragment madeirolide A has been achieved. key features the include stereocontrolled construction both THF and THP rings via visible-light-induced iridium-catalyzed radical cyclization late-stage union two oxacyclic subunits through nickel-catalyzed decarboxylative cross-coupling.
The synthesis of a fully elaborated C1–C10 fragment madeirolide A has been achieved via strategy based on series stereospecific processes. concise synthetic route also features an iridium-catalyzed visible light induced radical cyclization for construction the THP ring and palladium-catalyzed glycosylation formation α-cineruloside linkage.
Serum uromodulin concentration has been described as a novel biomarker of chronic kidney disease (CKD) in humans but not dogs.To evaluate the serum dogs with CKD and assess its diagnostic performance distinguishing from healthy dogs.Forty-nine (International Renal Interest Society [IRIS] Stage 1, n = 23; 2, 20; 3-4, 6) 25 controls.Prospective, observational study. was measured using canine-specific enzyme-linked immunosorbent assay (ELISA), correlation conventional renal markers...
This paper presents micromachined planar coaxial probes integrated with the active circuits for tumor detection and low-power cancer ablation. A multi-state reflectometer (MSR) consisting of a dual-band PLL, an impedance tuner, two power detectors, directional coupler is employed to extract broadband dielectric parameters cells. The are on silicon probe open-ended aperture. similar also demonstrated ablation, where voltage controlled oscillator, amplifiers together detectors coupler. To...
Abstract Background: Plasma cell-free DNA (cfDNA) analysis has emerged as an appealing alternative to detect somatic mutations. This study compared cfDNA at baseline (baseline-cfDNA) and progressive disease (PD-cfDNA) tumor tissue (ttDNA) in patients with metastatic gastric cancer who underwent palliative second-line paclitaxel+ramucirumab treatment. Methods: We conducted targeted sequencing of 106 cancer-related genes using germline DNA, baseline-cfDNA, PD-cfDNA samples. The results were...
Abstract Background: Plasma circulating tumor DNA (ctDNA) analysis has become an attractive method for precision oncology. This study compared mutational landscapes of ctDNA with matched tissue (ttDNA) to explore clinical applicability and better understand clonal evolution in patients metastatic colorectal cancer receiving palliative first-line systemic anti-cancer therapy (SACT). Methods: We performed unique molecular identifier-based targeted sequencing 88 cancer-associated genes using...
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a poor prognosis with early and frequent metastasis. While p21-activated kinase 4 (PAK4) has been implicated in cell migration, invasion, the molecular mechanisms PDAC remain unknown. In this study, we found that PAK4 overexpression was correlated survival patients through analysis of TCGA data. PAK4-amplified cells showed enhanced mobility contrast wild-type. knockdown amplified inhibited displacement increased stabilized...
Abstract Background Within the tumor microenvironment, altered lipid metabolism promotes cancer cell malignancy by activating oncogenic cascades; however, impact of in CD4 + tumor-infiltrating lymphocytes (TILs) remains poorly understood. Here, we elucidated that role stearoyl-CoA desaturase (SCD) increased treatment with cancer-associated fibroblast (CAF) supernatant T cells on their subset differentiation and activity CD8 cells. Results In our study, observed TILs had higher droplet...
Abstract Canine mammary gland tumors (CMTs) are the most common tumor type in female dogs. This study evaluated expression pattern and role of thyroglobulin (Tg) CMT human breast cancer (HBC). samples were subjected to fine‐needle aspiration, primary cell culture, histopathology. The level Tg was higher benign than malignant (mCMT) cells, particularly epithelial lineage. Moreover, treatment with enhanced sensitivity doxorubicin mCMT cells mitigated proinflammatory response by increasing...