A5082113615- Veterinary Oncology Research
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Virus-based gene therapy research
- Occupational and environmental lung diseases
- Herpesvirus Infections and Treatments
- MicroRNA in disease regulation
- Veterinary Equine Medical Research
- Veterinary Medicine and Surgery
- Infectious Diseases and Mycology
- Cytomegalovirus and herpesvirus research
- Microbial infections and disease research
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Nanoplatforms for cancer theranostics
- Salivary Gland Tumors Diagnosis and Treatment
- Cancer, Lipids, and Metabolism
- Renal and related cancers
- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Mycobacterium research and diagnosis
Seoul National University
2015-2025
New Generation University College
2023-2025
Shinshu University
2024
Korea Electric Power Corporation (South Korea)
2020
North Carolina State University
2007-2012
Chungnam National University
2012
National Institute of Environmental Health Sciences
2004-2006
National Institutes of Health
2005-2006
Triangle
2006
University of Georgia
2002-2004
In the hypoxic tumor microenvironment, cancer cells undergo metabolic reprogramming to survive. The present study aimed assess effects of conditions on lipid metabolism breast elucidate mechanisms by which survive in an unfavorable environment. Cell viability was assessed trypan blue staining, MTT and Annexin V‑PI assays. Intracellular levels were quantified using Nile red stain with immunofluorescence (IF). Autophagy detected LC3 antibody, Cyto‑ID stain, IF, Western blotting, flow...
Without the transcription factor p53 in cardiac endothelial cells, heart is more susceptible to radiation-induced damage.
Transmissible venereal tumor (TVT) is a well-documented transplantable in dogs, with no breed or sex predilection and low metastatic rate. In this report, 2-year-old intact female Mastiff that had numerous, rapidly growing masses throughout the subcutis mainly at dorsal body plane, caudal half of ventral abdomen, around vulva was euthanized due to poor prognosis. Neoplastic nodules similar those seen were also noted lung, anterior mediastinum, liver, spleen, kidney, superficial deep lymph...
Reactive oxygen species (ROS) are known to promote mesothelial carcinogenesis that is closely associated with asbestos fibers and inflammation. Epithelial mesenchymal cell transition (EMT) an important process involved in the progression of tumors, providing cancer cells aggressiveness. The present study was performed determine if EMT induced by H2O2 human malignant mesothelioma (HMM) cells. Cultured HMM were treated H2O2, followed measuring expression levels EMT-related genes proteins....
The goal of limb-sparing surgery for a soft tissue sarcoma the extremity is to remove all malignant cells while preserving limb function. After initial surgery, microscopic residual disease in tumor bed will cause local recurrence approximately 33% patients with sarcoma. To help identify these patients, authors developed an vivo imaging system investigate suitability molecular intraoperative visualization.A primary mouse model and wide field-of-view device were used series exogenously...
Abstract Genotoxic cancer therapies, such as chemoradiation, cause haematological toxicity primarily by activating the tumour suppressor p53. While inhibiting p53-mediated cell death during therapy ameliorates haematologic toxicity, whether it also impacts carcinogenesis remains unclear. Here we utilize a mouse model of inducible p53 short hairpin RNA (shRNA) to show that temporarily blocking total-body irradiation (TBI) not only acute but improves long-term survival preventing lymphoma...
Hypoxia is a hallmark of the solid tumor microenvironment and associated with poor outcomes in cancer patients. The present study was performed to investigate mechanisms underlying hypoxia-induced phenotypic changes using human malignant mesothelioma (HMM) cells. Hypoxic conditions were achieved by incubating HMM cells air chamber. effect hypoxia on phenotype investigated performing vitro clonogenicity, drug resistance, migration, invasion assays. Signaling pathways molecules involved more...
The role of microRNAs (miRNAs) as a post-transcriptional gene regulator has been elucidated in broad range organisms including domestic animals. Characterization miRNAs normal tissues is an important step to investigate the functions various physiological and pathological conditions. Using Illumina Next Generation Sequencing (NGS) technology, we identified total 292 known 329 novel horse skeletal muscle, colon liver. Distinct sets were differentially expressed tissue-specific manner. miRNA...
This report deals with the acute onset of an abortion outbreak and high sow mortality in one pig herd consisted 1,200 pigs 120 sows on Jeju Island, Korea.Affected pregnant showed clinical signs, including fever, gradual anorexia, vomiting, depression, recumbency, prostration, abortion, a few deaths.Four dead sows, five aborted fetuses from same litter, 17 sera collected infected or normal were submitted to Pathology Division National Veterinary Research Quarantine Service for diagnostic...
Non-small cell lung cancers (NSCLC) are a heterogeneous group of carcinomas harboring variety different gene mutations. We have utilized two distinct genetically engineered mouse models human NSCLC (adenocarcinoma) to investigate how genetic factors within tumor parenchymal cells influence the in vivo growth delay after one or fractions radiation therapy (RT).Primary adenocarcinomas were generated mice by intranasal delivery an adenovirus expressing Cre-recombinase. Lung expressed oncogenic...
Chemokines and their receptors play integral roles in carcinogenesis. CXC motif chemokine receptor 3 (CXCR3) T cells mediates anti-tumor effects, whereas CXCR3 malignant promotes proliferation metastasis. Although the role of has been well-documented human cancers, including breast cancer, its function canine tumors remains largely unexplored. This study aimed to investigate effects ligand interaction mammary gland tumor (cMGT) cells. expression two cMGT cell lines, CIPp CIPm, was evaluated...
An 11-year-old castrated male Turkish Angora cat presented with chronic lethargy and inappetence was diagnosed non-regenerative anemia, increased nucleated red blood cells, thrombocytopenia. Tests for anemia-related infections were negative. Imaging revealed pleural effusion, hepatomegaly, splenomegaly, enlarged abdominal lymph nodes, raising suspicion of a round cell tumor in the spleen. His anemia effusion did not improve despite chemotherapy cytarabine administration. Erythroid precursor...
Cancer-associated fibroblasts (CAFs) coordinate the malignancy of cancer cells via secretory materials. Reprogrammed lipid metabolism and signaling play critical roles in biology. Oleic acid (OA) serves as a source energy under glucose-deficient conditions, but its function progression remains unclear. The present study investigated that CAFs xenografted tumors had higher amounts fatty acids, particularly OA, compared to normal fibroblasts, promoted cell stemness lung adenocarcinoma...
The primo-vascular system (PVS), which consists of primo-vessels (PVs) and primo-nodes (PNs), is a novel thread-like structure identified in many animal species. Various observational methods have been used to clarify its anatomical properties. Here, we Hemacolor staining examine the gross morphology organ-surface PVS rats. We observed sinus (20-50 μ m) with remarkably low cellularity within PNs PVs several lines ductules (3-5 filled single cells or granules (~1 PV. Both sinuses were...
Intratumoral heterogeneity is a hallmark of all cancers and functions as the major barrier against effective cancer therapy.In contrast to genetic mutations, role epigenetic modifications in generation maintenance heterogeneous cells remains largely undetermined.This study was performed evaluate mechanisms involved tumor cell using side population (SP) non-SP isolated from human malignant mesothelioma (HMM) line.The subpopulations were analyzed by methylated DNA immunoprecipitation combined...
Abstract Background Evaluating regeneration is essential for the classification and differential diagnosis of anemia in dogs. Early detection challenging anemic Objectives This study assessed value immature reticulocyte fraction (IRF) differentiating preregenerative (PRA) from nonregenerative (NRA) Animals Ninety‐four dogs: 49 controls 45 with anemia. Methods Case‐control study. Fractions low‐, medium‐ (MFR), high‐fluorescence reticulocytes (HFR), were measured using ADVIA 2120i hematology...
Kaposi sarcoma-associated herpesvirus (KSHV) has been linked to sarcoma and B-cell malignancies. Mechanisms of KSHV-induced oncogenesis remain elusive, however, in part due lack reliable vivo models. Recently, we showed that transgenic mice expressing the KSHV latent genes, including all viral microRNAs, developed splenic B cell hyperplasia with 100% penetrance, but only a fraction converted lymphomas, suggesting cooperative oncogenic events were missing. Myc was chosen as possible...