Purpose A lower daily pill burden may improve adherence to antiretroviral treatment (ART) and clinical outcomes in patients with human immunodeficiency virus (HIV). This study assessed differences using the number of pills taken per day, evaluated how correlated hospitalization. Methodology Commercially insured LifeLink database an HIV diagnosis (International Classification Diseases, 9th Revision, Clinical Modification code 042.xx) between 6/1/2006 12/31/2008 receipt a complete ART regimen...

The mortality, length of hospitalization, and costs associated with invasive fungal infections (IFIs) in hospitalized patients were studied.This retrospective database study used data from the 2004 Healthcare Cost Utilization Project Nationwide In-patient Sample. Patients selected for inclusion based on diagnostic codes corresponding to an IFI. A control group was matched IFI high-risk conditions (i.e., cancer, infection human immunodeficiency virus, chronic obstructive pulmonary disease,...

Lower pill burden leads to improved antiretroviral therapy (ART) adherence among HIV patients. Simpler dosing regimens have not been widely explored in real-world populations. We retrospectively assessed ART adherence, all-cause hospitalisation risk and costs, other healthcare utilisation costs Medicaid enrollees with treated as a once-daily single-tablet regimen (STR) or two more pills per day (2+PPD).Patients an diagnosis from 2005 2009 receiving complete (ie, nucleoside/nucleotide reverse...

This analysis assessed rates of medication adherence and predictors nonadherence hospitalization among patients treated with long-acting injectable oral antipsychotic therapies.Data were from a retrospective Florida Medicaid recipients schizophrenic disorder (ICD-9-CM code 295.XX) who received prescription for an between July 1, 2004, June 30, 2005. Patients required to have filled one additional during follow-up. Adherence measures included possession ratio (MPR), persistence, consistency,...

To describe treatment patterns of migraine patients in the Japan Medical Data Center (JMDC) database.Patients aged ≥18 years with ≥1 inpatient or ≥2 outpatient diagnoses, diagnosis and migraine-specific acute (triptan ergotamine), treatments from 1 May 2011 to 30 April 2014 were identified. Patients required be enrolled a health plan for year before after index date. The first defined stratified by observed date (i.e. only [AT], prophylactic without [PT], no [NT]) described regarding regimen...

Objective: To assess rates of diagnosis and antihyperglycemic dose adjustment in patients with moderate to end-stage renal impairment (RI) type 2 diabetes mellitus (T2DM). Methods: Retrospective database analysis using GE Centricity Outpatient Electronic Medical Records. Patients aged ≥ 18 years evidence T2DM (International Classification Diseases, Ninth Edition, Clinical Modification codes 250.x0 250.x2) between January 1, 2000 June 30, 2009, 12 months data after identification were...

Type 2 diabetes mellitus (T2DM) affects 25.8 million individuals in the United States and exerts a substantial economic burden on patients, health care systems, society. Few studies have categorized costs resource use at patient level. The goals of this study were to assess predictors being high-cost (HC) compare HC T2DM patients with not (NHC) patients. Using managed administrative claims data, two or more diagnoses between 2005 2010 selected. Patients followed for 1 year after their first...

Aim: To assess the prevalence of high-risk atherosclerotic cardiovascular disease (ASCVD, defined as history acute coronary syndrome [hACS], cerebrovascular [CeVAD], peripheral artery [PAD], or w/diabetes [CADD]) and associated costs (CV) events in Japan.Methods: A retrospective analysis was conducted using Japan Medical Data Center (JMDC) database (2006–2011). ASCVD estimated on basis diagnoses for CeVAD, PAD, CADD, hACS (ACS claim >30–≤365 days after ACS-related hospitalization) during...

Individuals with chronic respiratory conditions may be at increased risk for pertussis. We conducted a retrospective administrative claims analysis to examine the incidence and economic burden of diagnosed pertussis among adolescents adults in USA obstructive pulmonary disease (COPD) or asthma. Patients aged ⩾11 years pre-existing COPD (n = 343) asthma 1041) were matched 1:1 patients but without Differences all-cause costs ('excess' costs) during 45-day 3-month 6-month periods before after...

Herpes zoster (HZ) incidence increases with age, and the burden of HZ is expected to grow aging populations worldwide. We aim determine incremental healthcare resource utilization associated costs patients common HZ-related complications other than postherpetic neuralgia (cutaneous, neurologic ophthalmic) compared uncomplicated HZ. conducted a retrospective cohort study commercial health insurance claims covering about 40 million immunocompetent individuals aged ≥50 years at entry from all...

To evaluate outcomes in insulin-naive patients with type 2 diabetes mellitus (T2DM) who initiated insulin glargine or detemir.Retrospective data were analyzed from the US General Electric Centricity electronic medical records (EMR) database (≥18 years old) T2DM initiating detemir between January 1, 2006, and December 31, 2010. Included had EMR for ≥6 months prior to (baseline) ≥12 after (follow-up) index date (date of first prescription), at least one OAD and/or GLP-1 receptor agonist...

This study examined treatment patterns, possible statin intolerance, and incidence of cardiovascular events (CVEs) in 2 cohorts patients with high risk (i.e., atherosclerotic disease [ASCVD] diabetes mellitus).

Approximately 33-50% of patients with systemic lupus erythematosus (SLE) develop organ damage within 5 years diagnosis. Real-world studies that capture the healthcare resource utilization (HCRU) and costs associated SLE-related are limited. The aim this study was to evaluate HCRU in SLE USA.This retrospective (GSK 208380) used PharMetrics Plus administrative claims database from 1 January 2008 30 June 2019. Patients were identified using International Classification Diseases (ICD)-9/10 codes...

Few peer-reviewed publications present real-world United States (US) data describing resource utilization and costs associated with herpes zoster (HZ) postherpetic neuralgia (PHN). The primary objective of this analysis (GSK study identifier: HO-14–14270) was to assess direct HZ PHN in the US using a retrospective managed care insurance claims database. Patients ≥ 50 y at diagnosis were selected. excluded if they immunocompromised before or received an vaccine any time. A subsample patients...

Objectives To examine prevalence, practice patterns, and associated burden of sliding scale insulin ( SSI ) therapy in elderly adults with type 2 diabetes (T2 DM ). Design A retrospective cross‐sectional study assessing merged medical chart data the M inimum D ata S et. Setting One hundred seventeen long‐term care LTC facilities seven U.S. states. Participants Elderly insulin‐treated T2 (N = 2,096) admitted to a facility after January 1, 2009, who had been for at least 3 months before...

This retrospective database analysis used data from the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample (NIS) to examine common primary diagnoses among children adolescents hospitalized with a secondary diagnosis of attention- deficit/hyperactivity disorder (ADHD) assessed burden ADHD. Hospitalized (aged 6-11 years) 12-17 ADHD were identified. The 10 most (using first 3 digits ICD-9-CM code) reported for each age group. Patients 1 these conditions selected analyze...

Treatment guidelines recommend a stepwise approach to glycemia management in patients with type 2 diabetes (T2D), but this may result uncontrolled glycated hemoglobin A1c (HbA1c) between steps. This retrospective analysis compared clinical and economic outcomes among T2D initiating two oral antidiabetes drugs (OADs), glucagon-like peptide-1 receptor agonists (GLP-1 RAs), or basal insulin real-world setting. Adults on OAD monotherapy were identified the MarketScan claims database (2007–2014)....

Many patients with type 2 diabetes do not reach glycemic goals despite basal insulin treatment. This study assessed the achievement of a target A1C <7.0% (<53 mmol/mol) after initiation in two settings.This was retrospective analysis pooled randomized controlled trial (RCT) data, from 11 24-week studies initiating performed between 2000 and 2005 outpatient electronic medical record (EMR) data General Electric Centricity database for insulin-naive 2012. Baseline characteristics stratified by...