A5100339046- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Genetics and Neurodevelopmental Disorders
- Genomics and Chromatin Dynamics
- Bioinformatics and Genomic Networks
- Invertebrate Immune Response Mechanisms
- Genomics and Phylogenetic Studies
- Immune cells in cancer
- FOXO transcription factor regulation
- DNA Repair Mechanisms
- interferon and immune responses
- Insect Resistance and Genetics
- Aquaculture disease management and microbiota
- Plant Virus Research Studies
- Photosynthetic Processes and Mechanisms
- Neuroscience and Neuropharmacology Research
- Ubiquitin and proteasome pathways
- Ferroptosis and cancer prognosis
- Metabolism, Diabetes, and Cancer
- Natural product bioactivities and synthesis
- Gene expression and cancer classification
- Animal Genetics and Reproduction
Dalian Medical University
2024-2025
Chongqing Medical University
2024-2025
Second Affiliated Hospital of Chongqing Medical University
2024-2025
Kunming Institute of Zoology
2024
Chinese Academy of Sciences
2024
University of Chinese Academy of Sciences
2024
Westlake University
2023
Tianjin Medical University
2021-2023
Guizhou Provincial People's Hospital
2023
Hong Kong Polytechnic University
2017-2021
The dynamic changes of RNA N6-methyl-adenosine (m6A) during cancer progression contribute to quick adaption microenvironmental changes. Here, we profiled the cell m6A dynamics in hypoxic tumor niche and its pathological consequences glioblastoma multiforme (GBM). demethylase ALKBH5 was induced GBM models under conditions associated with a gene signature patient samples. Depletion or inactivation cells significantly suppressed hypoxia-induced tumor-associated macrophage (TAM) recruitment...
Background The brown planthopper (BPH) Nilaparvata lugens (Stål) is one of the most serious insect pests rice in Asia. However, little known about mechanisms responsible for development, wing dimorphism and sex difference this species. Genomic information BPH currently unavailable, and, therefore, transcriptome expression profiling data species are needed as an important resource to better understand biological BPH. Methodology/Principal Findings In study, we performed de novo assembly gene...
The discovery of AD epigenetic signatures lays a molecular basis for new methods to detect early using patient blood cells.
CCCTC-binding factor (CTCF) is a DNA-binding protein that interacts with large number of highly divergent target sequences throughout the genome. It implicated in variety functions, including chromatin organization and transcriptional control. The functional role CTCF tumour pathogenesis remains elusive. We showed frequently upregulated subset primary hepatocellular carcinomas (HCCs) as compared non-tumoural liver. Overexpression was associated shorter disease-free survival patients. Short...
Bone morphogenetic protein 9 (BMP9) exhibits remarkable osteogenic potential. However, the intricate mechanisms driving this function of BMP9 remain elusive. This study endeavors to investigate potential role sirtuin 5 (SIRT5) in enhancing BMP9's capacity and decipher underlying molecular pathways. To achieve aim, we employed real-time PCR, western blotting, histochemical staining, a cranial defect repair model assess impact SIRT5 on BMP9-mediated osteogenesis. We utilized immunofluorescent...
This study mainly explores the possible role and mechanism of pyruvate dehydrogenase kinase 4 (PDK4) in onset development Glucocorticoid-induced osteoporosis (GIOP), seeks potential targets for treatment GIOP. Mesenchymal stem cells (MSCs) were treated with osteogenic induction medium. An vitro damage model was established by exposing MSCs to a high concentration (10− 6 M) dexamethasone (DEX). Osteogenic markers measured real-time quantitative polymerase chain reaction, western blot,...
Gene discovery in the Malaysian giant freshwater prawn (Macrobrachium rosenbergii) has been limited to small scale data collection, despite great interest various research fields related commercial significance of this species. Next generation sequencing technologies that have developed recently and enabled whole transcriptome (RNA-seq), allowed large functional genomics sets a shorter time than was previously possible. Using technology, three tissue types: hepatopancreas, gill muscle,...
TSPYL2 is an X-linked gene encoding a nucleosome assembly protein. interacts with calmodulin-associated serine/threonine kinase, which implicated in mental retardation. As and chromatin remodeling are important transcriptional regulation neuronal function, we addressed the importance of through analyzing Tspyl2 loss-of-function mice. We detected down-regulation N-methyl-D-aspartate receptor subunits 2A 2B (GluN2A GluN2B) mutant hippocampus. Evidence from luciferase reporter assays...
Abstract Background Gene expression technologies have the ability to generate vast amounts of data, yet there often resides only limited resources for subsequent validation studies. This necessitates perform sorting and prioritization output data. Previously described methodologies used functional pathways or transcriptional regulatory grouping sort genes further study. In this paper we demonstrate a comparative genomics based method leverage data from animal models prioritize validation....
Testis-specific protein, Y-encoded-like 2 (TSPYL2) is an X-linked gene in the locus for several neurodevelopmental disorders. We have previously shown that Tspyl2 knockout mice had impaired learning and sensorimotor gating, TSPYL2 facilitates expression of Grin2a Grin2b through interaction with CREB-binding protein. To identify other genes regulated by TSPYL2, here, we showed increased level H3K27 trimethylation (H3K27me3) hippocampus, interacted methyltransferase enhancer zeste (EZH2)....
Macrophages play an important role in the host defense mechanism. In response to infection, macrophages activate a genetic program of pro-inflammatory kill any invading pathogen, and initiate adaptive immune response. We have identified RUVBL2 - ATP-binding protein belonging AAA+ (ATPase associated with diverse cellular activities) superfamily ATPases as novel regulator macrophages. Gene knockdown Ruvbl2 , or pharmacological inhibition RUVBL1/2 activity, compromises type-2 nitric oxide...
It has been proposed that the energy-sensing enzyme AMP-activated protein kinase (AMPK) is a key agent in pathophysiology of type 2 diabetes mellitus (T2DM). The gene encoding catalytic subunit alpha (PRKAA2) located at one Asian T2DM loci (1p32). Therefore, aim present study was to test for association common variants PRKAA2 with Han Chinese population.We genotyped 221 patients and 111 controls assess possible associations two tagging single nucleotide polymorphisms (tSNPs) T2DM.The...
Once specific genes are identified through high throughput genomics technologies there is a need to sort the final gene list manageable size for validation studies. The triaging and sorting of often relies on use supplemental information related structure, metabolic pathways, chromosomal location. Yet in disease states where may not have identifiable structural elements, poorly defined or limited data, flexible systems obtaining additional data necessary. In these situations having tool...
Abstract Chromatin dynamics as well genetic evolution underlies the adaptability of tumour cells to environmental cues. Three subtypes have been identified in glioblastoma, one commonest malignant brain tumours adults. During progression or under therapeutic pressure, non‐mesenchymal may progress mesenchymal subtype, leading unfavourable prognosis. However, molecular mechanisms for this transition remain poorly understood. Here taking a TNFα‐induced cellular model, we profile chromatin...
Repressor elements play important roles in economic phenotypes of the pig, however, these remain poorly characterized. Here, we used H3K27me3, ATAC-seq and RNA-seq data derived from six tissues three embryonic layers to identify 2 034 super repressor (SREs) 22 223 typical (TREs) pig genome. Among identified elements, many are shared by mesodermal ectodermal tissues. SREs tightly regulate their target genes (within a specific genomic region, act on small number with strong effects) while...