A5018606891- Salmonella and Campylobacter epidemiology
- Listeria monocytogenes in Food Safety
- Viral gastroenteritis research and epidemiology
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Essential Oils and Antimicrobial Activity
- Antifungal resistance and susceptibility
- Endodontics and Root Canal Treatments
- Bacterial Identification and Susceptibility Testing
- Bacterial biofilms and quorum sensing
- Probiotics and Fermented Foods
- Oral health in cancer treatment
- Vibrio bacteria research studies
- Urinary Tract Infections Management
- Pneumonia and Respiratory Infections
- Head and Neck Cancer Studies
- Infections and bacterial resistance
- Immune Cell Function and Interaction
- Gut microbiota and health
- Immune Response and Inflammation
- COVID-19 Impact on Reproduction
- Reproductive System and Pregnancy
- Veterinary medicine and infectious diseases
- Nosocomial Infections in ICU
- Escherichia coli research studies
University of Rijeka
2016-2025
Klinički Bolnički Centar Rijeka
2007-2024
University Hospital Centre Zagreb
2011-2023
AstraZeneca (Germany)
2023
Vanderbilt University Medical Center
1987
OBJECTIVE : Oral lichen planus (OLP) is chronic inflammatory disease of the oral mucosa, presenting in various clinical forms. The etiology OLP still unknown but mounting evidence points to immunologic basis this disorder. Aim Our study was undertaken quantify salivary levels pro‐inflammatory tumor necrosis factor‐alpha (TNF‐α) reticular and erosive/atrophic forms OLP, compared with age‐matched healthy control volunteers. Subjects methods Whole saliva from 40 patients active lesions as well...
A population analysis of 103 multidrug-resistant Pseudomonas aeruginosa isolates from Croatian hospitals was performed. Twelve sequence types (STs) were identified, with a predominance international clones ST235 (serotype O11 [41%]), ST111 O12 [15%]), and ST132 O6 [11%]). Overexpression the natural AmpC cephalosporinase common (42%), but only few or produced VIM-1 VIM-2 metallo-β-lactamases PER-1 GES-7 extended-spectrum β-lactamases.
Pseudomonas aeruginosa is an opportunistic pathogen, one of the leading causes nosocomial infections such as pneumonia, urinary tract infections, and bacteraemia. The bacterial resistance to structurally unrelated antibiotics its spread within hospitals limits efficient antimicrobial options patients' outcome. Carbapenems are important agents for therapy due multidrug-resistant (MDR) P. aeruginosa; hence, development carbapenem severely hampers effective therapeutic options. aim this...
Bloodstream infection (BSI) is a critical medical emergency associated with high mortality rate. Rapid and accurate identification of the causative pathogen results antimicrobial susceptibility testing are crucial for initiating appropriate therapy. The aim this study was to evaluate performance new rapid PCR Molecular Mouse System (MMS) Gram-negative bacteria (GNB) GNB resistance genes directly from positive blood culture (BC). validation these multiplex assays carried out in real hospital...
ABSTRACT Brazil faces unique challenges in managing invasive fungal infections (IFIs) due to diverse ecosystems, a rural workforce, and prevalent health conditions. In Europe, IFIs are primarily associated with transplantation, intensive care, chronic diseases. Inspired by initiatives the Caribbean Latin America 2019, efforts map global diagnostic treatment resources expanded Africa, Asia/Pacific. This study conducts comparative analysis, mainly drawing data from investigate IFI epidemiology...
The benefi ts of probiotic bacteria have been widely explored.However, fermented foods and digestive system humans animals are an inexhaustible source new potentially microorganisms.In this study we present three Lactobacillus plantarum strains isolated from diff erent dairy products: cow′s cheese, sheep′s cheese whey.In order to determine the antibacterial activity yet unexplored L. against Salmonella enterica serotype Typhimurium, in vitro competition co-culture tests were...
Background We aimed to determine if there was a higher incidence of small intestinal bacterial overgrowth (SIBO) in non-alcoholic fatty liver disease (NAFLD) than patients without NAFLD. Moreover, we assessed whether with significant fibrosis (SF) had SIBO compared non-significant or no fibrosis. Methods NAFLD diagnosed 117 by using Fibroscan controlled attenuation parameter (CAP) as well biopsy (LB). defined esophagogastroduodenoscopy an aspiration the descending duodenum. Results Patients...
Significance There are a number of pathogens for which the immunity acquired postinfection does not fully protect against reinfection and disease. Therefore, vaccines offering superior protection compared with following natural infection needed. Due to unique pattern immune response induced by cytomegaloviruses (CMVs), live attenuated CMVs attractive candidates vaccine vectors. Here we have demonstrated that recombinant CMV vector expressing RAE-1γ, cellular ligand activating NKG2D receptor...
Background: Exposure to microorganisms elicts the production of cytokines. These soluble factors enhance several innate immune functions and regulate ensuing specific response aimed at limiting spread infection. Aim: This study was undertaken quantify plasma levels pro‐inflammatory cytokines during course primary Listeria monocytogenes Campylobacter jejuni Using an in vivo infection relationship between endogenous bacterial number liver infected animals examined. Methods: C57BL/6 mice were...
To determine the in vitro oxidative stress induced by conventional and self-ligating brackets made of different materials.The concentration marker 8-hydroxy-2'-deoxyguanosine (8-OHdG) DNA murine fibroblast cells L929 after exposure to three types four was assessed. viability changes number before exposure, trypan blue dye used. Analysis variance (ANOVA) used for statistical analysis.No significant difference cell noted between metal, ceramic, polymeric brackets, combinations those materials,...
Abstract Mycobacterium avium complex-related diseases are often associated with poorly maintained hot water systems. This calls for the development of new control strategies. The aim this study was to investigate activity essential oils (EOs) from Mediterranean plants, common juniper, immortelle, sage, lavandin, laurel, and white cedar against ssp. avium, intracellulare, gordonae in culturing broth freshwater as their most habitat. To do that, we developed a method microdilution determine...
Nontyphoidal salmonellae can cause breast infection only exceptionally. A case of abscess in a 70-year-old man due to Salmonella enterica serotype Enteritidis (Salmonella Enteritidis) is reported. The was successfully treated with combination surgical and antibiotic treatment.
Thermotolerant Campylobacter spp. frequently cause bacterial gastroenteritis in humans commonly infected through the consumption of undercooked poultry meat. We examined jejuni heat-stress responses vitro after exposure to 48°C and 55°C. The vivo modulation its pathogenicity was also investigated using BALB/c mice intravenously with stressed C. jejuni. Regardless growth phase, culturability viability reduced This correlated altered protein profile decreased virulence properties observed...
To evaluate the quality of antimicrobial drug use in a university hospital medical department (Department Medicine, University Hospital Rijeka, Croatia) with 279 hospital-beds wards containing patients from endocrinology, gastroenterology, hematology, clinical immunology, cardiology and coronary care unit, nephrology pulmonology sections hospital.The appropriateness treatment for all in-patients Department Medicine was assessed prospective, longitudinal survey carried out during 21-week...
Campylobacters have developed a number of mechanisms for responding to environmental conditions, although the different virulence properties these cells following exposure stress are still poorly understood. We analyzed in vitro responses and consequent vivo modulation Campylobacter jejuni pathogenicity BALB/c mice, as result C. (starvation, oxidative stress, heat shock). In vitro, influence starvation was milder than that shock, majority conditions influenced survival jejuni. During...
The present study evaluated the possible synergistic antimycobacterial interactions of Juniperus communis and Helichrysum italicum essential oils (EO).Antimycobacterial potential was tested against Mycobacterium avium intracellulare using broth water dilution method checkerboard synergy method. Antiadhesion antibiofilm effect EOs on biotic (HeLa cells) abiotic surface (polystyrene). To evaluate mechanisms action, cellular leakage proteins DNA structural changes were visualized with a...