A5085850882- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Hepatocellular Carcinoma Treatment and Prognosis
- Liver Disease Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Cancer-related molecular mechanisms research
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Dialysis and Renal Disease Management
- Cancer Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Liver Disease and Transplantation
- Liver physiology and pathology
- Metastasis and carcinoma case studies
- Medical Imaging and Pathology Studies
- Abdominal vascular conditions and treatments
- Light effects on plants
- Genetic factors in colorectal cancer
- Renal cell carcinoma treatment
- Metabolism and Genetic Disorders
- Endometriosis Research and Treatment
- Mycobacterium research and diagnosis
- Hemophilia Treatment and Research
- Tracheal and airway disorders
- Gastrointestinal Bleeding Diagnosis and Treatment
Dokuz Eylül University
2010-2024
University of California, San Francisco
2011-2015
The primary origin of some ovarian mucinous tumors may be challenging to determine, because metastases extraovarian exhibit gross, microscopic, and immunohistochemical features that are shared by tumors. Metastases colorectal, appendiceal, gastric, pancreatic, endocervical adenocarcinomas simulate cystadenoma, borderline tumor, or adenocarcinoma. Recently, expression SATB2, a transcriptional regulator involved in osteoblastic neuronal differentiation, has been shown highly sensitive marker...
A subset of women with uterine cancer exhibiting defective mismatch repair (MMR) proteins and microsatellite instability (MSI) may have Lynch syndrome, which also confers a risk for colorectal other cancers in the patient her family. Screening algorithms based on clinical pathologic criteria are effective determining patients most likely to benefit from definitive genetic testing syndrome. Ovarian cancer, particularly endometrioid adenocarcinoma, is associated although much smaller than...
Transitional cell-like growth has been reported as a morphologic variant of endometrioid adenocarcinoma in the uterus but is not well-described ovary. We report clinicopathologic features series ovarian adenocarcinomas with transitional morphology, emphasizing distinction from its mimics, including high-grade serous carcinoma, cell and granulosa tumor. Among cohort 71 surgically staged at our institution, 10 tumors (14%) exhibited morphology. Patient age ranged 39 to 79 years (mean, 52 y)....
Glucagon like peptide-2 may play an important role in human colon cancer and polyp development because of its proliferative antiapopitotic effects especially colon. In this study, we investigated the glucagon peptide it's receptor colorectal carcinogenesis.The study includes 30 patients group 20 colonic who have been diagnosed by endoscopic pathologic examination Dokuz Eylül University, Department Gastroenterology within 2 year-period. For comparison biopsies were taken from normal appearing...
Alterations in the expression of several long non-coding RNAs (lncRNAs) have been shown chronic hepatitis B-associated hepatocellular carcinoma (CHB-HCC). Here, we aimed to investigate association between inflammation-associated lncRNA X-inactive specific transcript (XIST) and type inflammatory cells within tumor microenvironment.
The aim of this study is to assess the influence darbepoetin on development peritoneal fibrosis in rats induced by Chlorhexidine gluconate (0.1%) and ethanol (15%) determine effect tissue levels MMP–2 TIMP–2, possible important factors progression fibrosis. Twenty-four female Wistar albino were divided into three groups. first group (CH group) received 3 ml/200g daily intraperitoneal injections dissolved saline induce chemical peritonitis; 2 (ESA also 12.5 microgr/ per kilogram/ day...
In today's pathology practice, pathologists combine molecular tests with conventional histopathological methods. Pathology laboratories should therefore be designed and operated in accordance the requirements of testing procedures. While specifics may vary depending on spectrum that will performed, there are several basic criteria need to fulfilled for standardization. Adequate space, appropriate equipment qualified personnel required establish a laboratory. One most important points taken...
Introduction: Various potential prognostic histopathologic factors for colorectal carcinoma liver metastasis have been proposed. However, there is still no consensus on pathological reporting of resection materials. The aim this study was to investigate the relation between selected tumoral and parenchymal features better characterization prediction patients with metastasis. Methods: Hematoxylin-eosin stained slides from 100 who underwent hepatic were evaluated. Pathologic characteristics;...
This study investigated the effect of interferon alpha2b on chlorhexidine gluconate (CH)-induced peritoneal fibrosis (PF) in rats and assessed tissue levels metalloproteinase (MMP)-2 inhibitors metalloproteinases (TIMP)-2. Wistar albino (n = 8 per group) were treated as follows: control group, 3 ml/day 0.9% saline intra-peritoneally for 28 days; CH 0.1% (200 g[3 ml]/day) 15% ethanol + (IFN) (as above) plus pegylated IFN-alpha2b 1.5 mug/kg week subcutaneously days 0, 7, 14, 21 28; IFN above)....
Objective: Seroma occurs as a result of accumulation lymphovascular liquid in the dead space forming after tissue dissection.It is most common complication breast surgery.Collagens are component extracellular matrix and have an important role wound healing.In this study, we aimed to investigate efficiency Porcine Dermal Collagen preventing Seroma. Materials methods:Eighteen young female Wistar rats were used divided into three groups.Mastectomy axillary dissection performed each group.No...
Purpose: To investigate the relevance between cancer stem cell(CSC) markers and tumor progression in hepatocellular carcinoma(HCC). Methods: Data of patients who underwent liver transplantation(LT) for HCC February 1998 September 2018 were collected. Patients over 18 years age included. Immunohistochemical staining performed paraffin blocks explants containing terms CSC markers, CD13, CD44, CD47, CD90 EpCAM. Follow-up period, recurrence, disease-free overall survival investigated. Results:...
This study aimed to identify the expression profile and prognostic significance of inflammation-associated lncRNAs in chronic viral hepatitis (CVH) CVH-associated hepatocellular carcinoma (CVH-HCC).
ÖZETÇok basamaklı karsinogenez teorisine göre başlangıç evresinde ortaya çıkan geri dönüşsüz genetik değişiklikler zaman içerisinde çevresel faktörlerin de etkisiyle hücrenin klonal proliferasyonuna
Data on peritumoral histopathologic findings in patients with hepatocellular carcinoma (HCC) is limited. In this retrospective study, we evaluated the changes chronic viral hepatitis (CVH)-associated HCC (CVH-HCC) and their prognostic value. 61 consecutive cirrhotic who underwent liver transplantation due to CVH-HCC were included. Histopathologic features within 1 cm distance of tumor, association clinicopathological characteristics prognosis evaluated. A random representative slide...
The placenta is the major regulatory element of in-utero environment, and alterations in placental cellular functions infection, inflammation, hypoxemia lead to adverse preterm birth outcomes. importance regulation autophagy inflammasome activities has been shown pathogenesis morbidities immature animal models. This study aimed determine relationship between with morbidity extremely infants.Premature infants born 24th 29th gestational weeks were evaluated prospectively. Placental LC3B NLRP3...
Pleuropulmonary blastoma is rare embryonal tumor of infancy and early childhood it often arises from lung more rarely the parietal pleura. We present this entity which has no systematic data associated with its incidence in order to discuss clinical, histopathological, immunohistochemical features differential diagnosis. A three-year-old boy presented fever showed signs upper respiratory tract infection. Radiological examination revealed a solid mass filling right hemithorax. The patient...
Circulating tumor cells (CTCs) are cancer which separate from the primary and enter systemic circulation. In this study, it was aimed to examine relationship between CTCs isolated identified peripheral blood of patients with pancreatobiliary cancer, clinicopathological characteristics their overall survival.A total 21 were included study. Density gradient centrifugation OncoQuick® assay performed for isolation blood. order identify CTCs, enriched samples underwent flow cytometric...
Aim: Liver transplantation (LT) is the most effective treatment method for preventing progressive and lethal complications of Wilson’s disease (WD). Despite deceased donor liver (DDLT) living (LDLT) are performed in many centers WD, a limited number reports were published, about long-term results. The aim this study to share outcomes single center.Material Methods: Patients who underwent LT between 1997 2017 included. Patient’s survival data, death causes, neurological symptoms follow-up...