A5080629982- Exercise and Physiological Responses
- Sports and Physical Education Research
- Histone Deacetylase Inhibitors Research
- Growth Hormone and Insulin-like Growth Factors
- Sports Performance and Training
- Genetics and Neurodevelopmental Disorders
- Genetics and Physical Performance
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- Adipokines, Inflammation, and Metabolic Diseases
- Neurogenesis and neuroplasticity mechanisms
- Cardiovascular and exercise physiology
- Muscle metabolism and nutrition
- Circular RNAs in diseases
- Axon Guidance and Neuronal Signaling
- Radiopharmaceutical Chemistry and Applications
- Traditional Chinese Medicine Analysis
- Adipose Tissue and Metabolism
- Physical Education and Training Studies
- MicroRNA in disease regulation
- Human-Automation Interaction and Safety
- Nutrition, Genetics, and Disease
- Plant biochemistry and biosynthesis
- High Altitude and Hypoxia
- Erythrocyte Function and Pathophysiology
Xiamen University of Technology
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
China Agricultural University
2022
HBIS (China)
2022
University of North Carolina at Chapel Hill
2007-2012
Macao Polytechnic University
2004-2005
Shanghai University of Sport
1999
Abstract Both in vivo and vitro studies indicate a correlation between reduced acetylation of histone core proteins oligodendrocyte development. The nature these modifications the mechanisms mediating them remain undefined. To address issues, we utilized OL‐1 cells, rat nontransformed cell line, primary cultures. We found that acetylated H3 at lysine 9 14 (H3K9/K14ac) is both myelin basic protein (MBP) proteolipid (PLP) genes maturing oligodendroglial furthermore, this temporally correlates...
Abstract Recent studies indicate that neural cell development in the central nervous system (CNS) correlates with a reduction acetylation of histone core proteins. Moreover, hypoacetylation is thought to be important oligodendrocyte lineage development. The mechanisms mediating during postnatal remain defined. To begin understand these mechanisms, we investigated expression deacetylase 11 (HDAC11), newly identified HDAC, mouse brain We show HDAC11 was widely expressed and this gradually...
Astragalus membranaceus var. mongholicus (AMM), a member of the Leguminosae, is one most important medicinal plants worldwide. The dried roots AMM have wide range pharmacological effects and are traditional Chinese medicine. Here, we report first chromosome-level reference genome AMM, comprising nine pseudochromosomes with total size 1.47 Gb 27 868 protein-encoding genes. Comparative genomic analysis reveals that has not experienced an independent whole-genome duplication (WGD) event after...
Abstract By promoting cell proliferation, survival and maturation insulin‐like growth factor (IGF)‐I is essential to the normal development of central nervous system. It clear that IGF‐I actions are primarily mediated by type I IGF receptor (IGF1R), phosphoinositide 3 (PI3)‐Akt kinases MAP signal many IGF‐I‐IGF1R in neural cells, including oligodendrocyte lineage cells. The precise downstream targets these signaling pathways, however, remain be defined. We studied oligodendroglial cells...
Informative warnings can improve takeover performance in automated vehicles, but improper or excessive information may hinder it. This study investigates the optimal amount of urgent and non-urgent autonomous transitions. Forty-five drivers were randomly assigned to groups receiving different amounts selected warning elements. Each group completed simulated tasks four scenarios with urgency. Takeover performance, situation awareness, stress levels measured. The results indicate that,...
Signalling through the IGF1R [type 1 IGF (insulin-like growth factor) receptor] and canonical Wnt signalling are two pathways that play critical roles in regulating neural cell generation growth. To determine whether can interact with pathway cells vivo, we studied mutant mice altered signalling. We found blunted expression specifically nestin-expressing (IGF1RNestin-KO mice) abundance of β-catenin was significantly reduced. Blunting also markedly decreased: (i) activity a LacZ...
Peptide-based radiopharmaceuticals targeting integrin α5β1 show promise for precise tumor diagnosis and treatment. However, current peptide-based radioligands that target demonstrate inadequate in vivo performance owing to limited retention. The use of PEGylation enhance the retention by prolonging blood circulation time poses a risk increased toxicity. Therefore, strategy boosts while minimizing is urgently needed. Here, we developed PEGylation-enabled peptide multidisplay platform...
In this paper, Zhong Guan iron ore is used as raw material. By adjusting the content of lime, magnesium powder and bentonite, effect law different SiO<sub>2</sub>, MgO alkalinity on compressive strength pellet under low silicon conditions was studied, And change systematically analyzed from microscopic morphology structure perspective. The results study show that increasing roasting temperature can effectively improve pellets. At SiO<sub>2</sub> content, mainly cemented by hematite...
In this study, we investigated the relationship between serum glutamic acid decarboxylase (GAD) autoantibody (Ab) levels and single nucleotide polymorphisms (SNPs) of de-carboxylase 2 (GAD2) 5'-untranslated region susceptibility to type diabetes in Han population. The distributions patients with SNPs GAD2 (rs2236418, rs185649317, rs8190590) that healthy group were genotyped analyzed using Sequenom MassArray SNP genotyp-ing. GAD-Ab also detected. frequency AA, AG, GG genotypes polymorphic...
0468 PURPOSE: To determine the validities of 1600-m run test and several anthropometric variables measurements for predicting VO2max Singapore children aged 10–12 years. METHODS: 20 untrained subjects, 15 boys 5 girls participated in a test, which was administered using standardized instructions following procedures typically employed National Physical Fitness Award (NAPFA) fitness testing schools Singapore. HR monitored Polar Vantage XL monitor during running time recorded Citizen...
0468 PURPOSE: To determine the validities of 1600-m run test and several anthropometric variables measurements for predicting VO2max Singapore children aged 10–12 years. METHODS: 20 untrained subjects, 15 boys 5 girls participated in a test, which was administered using standardized instructions following procedures typically employed National Physical Fitness Award (NAPFA) fitness testing schools Singapore. HR monitored Polar Vantage XL monitor during running time recorded Citizen...
1753 PURPOSE: The study is to investigate: 1. effect of training status on the immune adherence erythrocytes; 2. different intensities and durations exercises 3. effects uphill downhill running erythrocytes. METHODS: Thirty male volunteers were divided into trained (T) untrained (U) groups. U included 15 sedentary males (22.97 ± 0.70 yrs), T endurance athletes (24.69 0.82 yrs). All participants performed five separate treadmill exercise trials: maximal oxygen uptake (VO2 max) test (T1), at...
PURPOSE The immune functions of erythrocytes and leucocytes co-adjust, interrelate interact within the body, which jointly complete defense against pathogens. This study aimed to investigate changes in activities complement receptors on lymphocytes after different treadmill exercises, determine relationship between adherent physical exercise. METHODS Thirty male volunteers (age: 23.83±3.04yrs; body mass: 64.61±8.39 kg; stature: 1.73±0.06 m) performed five separate exercise trials: maximal...
PURPOSE To determine the validities of 1600-m run test and several anthropometric variables measurements for predicting VO2max Singapore children aged 10–12 years. METHODS 20 untrained subjects, 15 boys 5 girls participated in a test, which was administered using standardized instructions following procedures typically employed National Physical Fitness Award (NAPFA) fitness testing schools Singapore. HR monitored Polar Vantage XL monitor during running time recorded Citizen stopwatch. Five...
PURPOSE The immune functions of erythrocytes and leucocytes co-adjust, interrelate interact within the body, which jointly complete defense against pathogens. This study aimed to investigate changes in activities complement receptors on lymphocytes after different treadmill exercises, determine relationship between adherent physical exercise. METHODS Thirty male volunteers (age: 23.83±3.04yrs; body mass: 64.61±8.39 kg; stature: 1.73±0.06 m) performed five separate exercise trials: maximal...
PURPOSE To determine the validities of 1600-m run test and several anthropometric variables measurements for predicting VO2max Singapore children aged 10–12 years. METHODS 20 untrained subjects, 15 boys 5 girls participated in a test, which was administered using standardized instructions following procedures typically employed National Physical Fitness Award (NAPFA) fitness testing schools Singapore. HR monitored Polar Vantage XL monitor during running time recorded Citizen stopwatch. Five...
1753 PURPOSE: The study is to investigate: 1. effect of training status on the immune adherence erythrocytes; 2. different intensities and durations exercises 3. effects uphill downhill running erythrocytes. METHODS: Thirty male volunteers were divided into trained (T) untrained (U) groups. U included 15 sedentary males (22.97 ± 0.70 yrs), T endurance athletes (24.69 0.82 yrs). All participants performed five separate treadmill exercise trials: maximal oxygen uptake (VO2 max) test (T1), at...