A5001591717- Microbial Natural Products and Biosynthesis
- Phytochemicals and Antioxidant Activities
- Plant Gene Expression Analysis
- Genomics and Phylogenetic Studies
- Microbial Community Ecology and Physiology
- Traditional and Medicinal Uses of Annonaceae
- Plant Pathogens and Fungal Diseases
- Plant biochemistry and biosynthesis
- Malaria Research and Control
- Plant-Microbe Interactions and Immunity
- Parasitic Infections and Diagnostics
- Biochemical and Molecular Research
- Plant Disease Resistance and Genetics
- Microbial Metabolism and Applications
- Bioactive Compounds and Antitumor Agents
- Amoebic Infections and Treatments
- Reproductive Biology and Fertility
- Natural product bioactivities and synthesis
- Light effects on plants
- Pneumocystis jirovecii pneumonia detection and treatment
- Connective tissue disorders research
- Entomopathogenic Microorganisms in Pest Control
- Plant Pathogens and Resistance
- Mosquito-borne diseases and control
- Cancer therapeutics and mechanisms
Okayama University
2025
National Institute of Technology and Evaluation
2021-2024
Kitasato University
2014-2023
Kitasato Institute Hospital
2011-2022
Tokyo Metropolitan Agriculture and Forestry Research Center
2017
The University of Tokyo
2009-2016
Nagoya University
2003-2015
Kyushu University
2013
Yamaguchi University
2002-2009
Kyoto Institute of Technology
2009
Abstract Microbes can decompose biodegradable plastics on land, rivers and seashore. However, it is unclear whether deep-sea microbes degrade in the extreme environmental conditions of seafloor. Here, we report microbial decomposition representative (polyhydroxyalkanoates, polyesters, polysaccharide esters) at diverse floor locations ranging depth from 757 to 5552 m. The degradation samples was evaluated terms weight loss, reduction material thickness, surface morphological changes. Poly( l...
Microbial natural products possess a wide range of biological and biochemical potential. Among them, fungal secondary metabolites are one the most important sources for discovering new drugs or lead compounds. In present study, we explored substances produced by strain Penicillium sp. FKI-7127 its antiviral activity. We identified brefeldin A as novel agent against dengue viruses. The inhibitory effect was confirmed virus titer immunofluorescence assay. Brefeldin inhibited viruses regardless...
The petal color of morning glory, Ipomoea tricolor cv. Heavenly Blue, changes from purplish red to blue during flower opening. This change is caused by an unusual increase in vacuolar pH 6.6 7.7 the colored adaxial and abaxial cells. To clarify mechanism underlying alkalization epidermal vacuoles open petals, we focused on H+-ATPase (V-ATPase), H+-pyrophosphatase (V-PPase) isoform Na+/H+ exchanger (NHX1). We isolated protoplasts petals bud fully flower, respectively, purified membranes....
Tuberculosis is the leading cause of death due to a single infectious agent in world and emergence multidrug-resistant strains prompted us develop new drugs with novel targets mechanism. Here, we screened natural antibiotics library Mycobacterium smegmatis membrane-bound dehydrogenases identified polymyxin B (cationic decapeptide) nanaomycin A (naphtoquinone derivative) as inhibitors alternative NADH dehydrogenase [50% inhibitory concentration (IC50) values 1.6 31 μg/ml, respectively]...
The levels of C-reactive protein (CRP) and serum amyloid A (SAA) in blood are increased patients with inflammatory diseases as acute phase proteins. Most the presently used indicators inflammation, such body temperature, white cell count, erythrocyte sedimentation rate or CRP, non-specific parameters. In contrast, procalcitonin (PCT) has been reported to be selectively induced by severe bacterial infection during systemic response syndrome (SIRS), also sepsis multiorgan dysfunction syndrome....
Journal Article Siccanin Rediscovered as a Species-Selective Succinate Dehydrogenase Inhibitor Get access Tatsushi Mogi, Mogi * 1Department of Biomedical Chemistry, the University Tokyo, Bunkyo-ku, Tokyo 113-0033; 2Department Biotechnology, 113-8657; 3Department Biological Faculty Agriculture, Yamaguchi University, 753-8515; 4Kitasato Institute for Life Sciences and Graduate School Infection Control Sciences, Kitasato Minato-ku, 108-8641; 5Department Applied Biology, Kyoto Technology,...
Amebiasis is a common worldwide diarrheal disease, caused by the protozoan parasite, Entamoeba histolytica. Metronidazole has been drug of choice against amebiasis for decades despite its known side effects and low efficacy asymptomatic cyst carriers. E. histolytica also capable surviving sub-therapeutic levels metronidazole in vitro. Novel drugs with different mode action are therefore urgently needed. The sulfur assimilatory de novo L-cysteine biosynthetic pathway essential various...
The novel actinomycete strain PWB-003T, which produced fluostatins B and C antibiotics, was isolated from nearshore sediment collected Panwa Cape, Phuket Province, Thailand. Data the present polyphasic study indicated that PWB-003T represented a member of genus Micromonospora. It single spores on substrate mycelia contained meso-diaminopimelic acid in cell-wall peptidoglycan. Whole-cell hydrolysate ribose, xylose, arabinose, mannose glucose. predominant menaquinone MK-10 (H4). Cellular fatty...
Contents This study was designed to examine the effects of age and developmental stage in vitro ‐produced bovine embryos on cell number investigate correlation between diameter embryos. The blastocysts expanded collected days 7–9 after fertilization (IVF) were examined. Although diameters 7 8 IVF smaller than those day 9, both types similar. numbers decreased with increasing embryo age. There positive correlations at each IVF. However, value coefficient day‐9 blastocyst group tended be...
A novel species of the genus Actinoplanes, strain LDG1-22T, for which we propose name Actinoplanes lichenis sp. nov., was isolated from a lichen sample collected tree bark in Thailand. The taxonomic position has been described based on polyphasic approach. Strain LDG1-22T produced irregular sporangia agar media. It contained meso-diaminopimelic acid cell-wall peptidoglycan. major menaquinone MK-9(H4); polar lipids were diphosphatidylglycerol, phosphatidylethanolamine, phosphatidylinositol,...
Abstract Asymmetric synthesis and initial biological studies of two analogues a naturally occurring chlorinated antifungal agent, atpenin A5, are described. These were selected on the basis Cl→CH 3 or H C→Cl exchanges in side‐chain A5. The interchange chloro methyl substituents led to complex II inhibitors with equal IC 50 values. This suggests that Cl↔Me bioisosteric exchange can be realized aliphatic settings.
Amebiasis is caused by infection with the parasite, Entamoeba histolytica. Although metronidazole has been used against amebiasis, it shows side effects and low efficacy asymptomatic cyst carriers. Therefore, drugs new mode of action or targets are urgently needed. L-cysteine major thiol an essential amino acid for proliferation anti-oxidative defense E. histolytica possesses de novo biosynthetic pathway, consisting two reactions catalyzed serine acetyltransferase cysteine synthase (CS). As...