A5055087192- Veterinary Equine Medical Research
- Cardiac electrophysiology and arrhythmias
- Cardiovascular Effects of Exercise
- Ion channel regulation and function
- Cardiovascular Conditions and Treatments
- Sports Performance and Training
- Viral Infections and Vectors
- Animal health and immunology
- Mosquito-borne diseases and control
- Cardiac Valve Diseases and Treatments
- Muscle Physiology and Disorders
- Heart Rate Variability and Autonomic Control
- Reproductive Physiology in Livestock
- Cancer Research and Treatments
- Immunotherapy and Immune Responses
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Mesenchymal stem cell research
- Animal Disease Management and Epidemiology
- Meat and Animal Product Quality
- Muscle metabolism and nutrition
- Virus-based gene therapy research
- Cardiac Arrest and Resuscitation
- Veterinary Pharmacology and Anesthesia
- Genetic Neurodegenerative Diseases
University of Veterinary Medicine Vienna
2022-2023
University of Copenhagen
2016-2022
Freie Universität Berlin
2020-2022
Institut für Medizinische Biometrie, Informatik und Epidemiologie
2022
University of Vienna
2022
University Children’s Hospital Basel
2021
Kantonsspital Aarau
2021
École Nationale Vétérinaire d'Alfort
2015-2018
Laboratoire Animal et Agroécosystèmes
2016
University of Bern
2004-2015
Patients with inoperable pancreatic cancer have a dismal prognosis mean life expectancy of 3–6 months. New treatment modalities are thus urgently needed. Telomerase is expressed in 85–90% pancreas cancer, and immunogenic telomerase peptides been characterised. A phase I/II study was conducted to investigate the safety, tolerability, immunogenecity peptide vaccination. Survival patients also recorded. Forty-eight non-resectable received intradermal injections GV1001 at three dose levels,...
Summary Reasons for performing the study: Admission L‐lactate concentration is a useful and commonly measured biomarker not previously prospectively evaluated in large multicentre study of critically ill neonatal foals. Objectives: To evaluate overall outcome association survival at admission ([LAC] ADMIT ) by periparturient history, presenting complaint clinicians' major diagnosis Methods: Thirteen university private equine referral hospitals enrolled 643 foals over 2008 foaling season....
Summary Reasons for performing study: Standardised exercise tests are used fitness evaluation of sports horses. Standards described Thoroughbreds and Standardbreds; however, limited information is available Warmbloods. Objectives: To establish normative standards performance parameters heart rate recovery (HRR) in Warmblood riding horses different levels using a submaximal incremental test (SIET) performed on treadmill. Methods: A SIET was carried out with 29 healthy treadmill‐accustomed...
Following the introduction of West Nile virus (WNV) into eastern Germany in 2018, increasing infections have been diagnosed birds, equines, and humans over time, while spread WNV western remained unclear. We screened 437 equine sera from 2018 to 2020, excluding vaccinated horses, collected convenience sampled patients parts Germany, for WNV-specific antibodies (ELISAs followed by virus/specific neutralization tests) genomes (RT-qPCRs). Clinical presentations, final diagnoses, demographic...
Analysis of the heart rate variability (HRV) gains more and importance in assessment training practice welfare equine industry. It relies on mathematical analyses reliably accurately measured variations successive inter-beat intervals, as RR intervals. Nowadays, intervals can be obtained through two different techniques: a meter (HRM) or an electrocardiogram (ECG). The agreement reliability these devices has not been fully assessed, especially for recordings during exercise. purpose this...
Summary Reasons for performing study: Frequent supraventricular or ventricular arrhythmias during and after exercise are considered pathological in horses. Prevalence of seen apparently healthy horses is still a matter debate may depend on breed, athletic condition intensity. Objectives: To determine intra‐ interobserver agreement detection at rest, using telemetric electrocardiography device. Materials methods: The electrocardiogram (ECG) recordings 10 Warmblood (5 which had an intracardiac...
The heart's physiological adaptation to aerobic training leads an increase in heart chamber size, and is referred as the Athlete's heart. However, dimensions are also related body weight (BWT), growth (in some species) breed. There few published data on relationships between or Arabian Arabian-related endurance horses. Therefore objective of present study was describe influence (body length (BL), thoracic circumference (TC), withers height (WH)), BWT, age, gender, breed (purebred Arabians,...
As evidenced by sero-epidemiological studies, infections of horses with the tick-borne encephalitis virus (TBEV) occur frequently in TBEV-endemic areas. However, there are only very few reports clinical cases. A possible underreporting may be due to a variety diagnostic challenges. In this study, ELISA and neutralization tests were applied serum samples. Brain tissue samples investigated for presence nucleic acids TBEV, Equid alphaherpesvirus 1, Borna disease West Nile Usutu viruses,...
The investigation of multipotent stem/stromal cells (MSCs) in vitro represents an important basis for translational studies large animal models. study's aim was to examine and compare clinically relevant properties equine MSCs, which were isolated from abdominal (abd), retrobulbar (rb) subcutaneous (sc) adipose tissue by collagenase digestion (ASCs-SVF) explant technique (ASCs-EXP). Firstly, we examined proliferation trilineage differentiation and, secondly, the cardiomyogenic potential...
Heart rate variability (HRV) is a noninvasive technique to detect changes in the autonomous nervous system. It has rarely been investigated horses with colic. Therefore, objective was assess evolution of HRV parameters and cortisol concentrations The 43 included this study were categorized into three groups according treatment (1, surgical; 2, conservative; 3, euthanized). laboratory variables measured at admission (T1), day after (T2), discharge (T3) compared between over time an ANOVA...
1 Abstract A high-quality reference genome assembly, a biobank of diverse equine tissues from the Functional Annotation Animal Genome (FAANG) initiative, and incorporation long-read sequencing technologies, have enabled efforts to build comprehensive tissue-specific transcriptome. The FAANG transcriptome reported here provides up 45% improvement in completeness across tissue types when compared either RefSeq or Ensembl transcriptomes. This also major improvements identification alternatively...
The present retrospective study describes the diagnostic workup and collected findings in 7 horses with chronic inflammatory bowel disease over years 2000-2006. diagnosis could be confirmed histologically biopsies taken during laparoscopy or laparotomy post mortem examination. Weight loss diarrhoea were most commonly reported clinical findings. Among ancillary examinations (fecal analysis, gastroscopy, abdominal ultrasonography, rectal mucosal biopsy) D-xylose absorption test provided useful...
The long QT syndrome ( LQTS ) is a channelopathy that can lead to severe arrhythmia and sudden cardiac death. Pharmacologically induced caused by interaction between drugs potassium channels, especially the K v 11.1 channel. Due such interactions, numerous have been withdrawn from market or are administered with precautions in human medicine. However, some compounds, as trimethoprim–sulfonamide combinations still widely used veterinarian Therefore, we investigate effect of...
Physiological particularities of the equine heart justify development an in vitro model suitable for investigations species-specific cardiac electrophysiology. Adipose tissue-derived stromal/stem cells (ASCs) could be a promising starting point from which to develop such cardiomyocyte (CM)-like cell model. Therefore, we compared abdominal, retrobulbar, and subcutaneous adipose tissue as sources isolation ASCs applying two methods: collagenase digestion direct explant culture. Abdominal was...
8031 Background: A phase I/II feasibility study was conducted to investigate the safety, tolerability and immunological response vaccination with telomerase peptide GV1001 (hTERT: 611–626) in combination temozolomide (T). Methods: Twenty-five patients malignant melanoma (15 stage M1c,10 M1b) received T day 1–5 every four weeks for 1–9 cycles. During first cycle (4 weeks) they i.d. injections of 560 μg local GM-CSF week 2,3 4, followed by 6 7 second 11 third cycle. The treatment period 12 (3...
A 14-year old Swiss warmblood gelding was presented to the equine hospital of University Zurich because therapy-resistant fever. An intermittent lameness suggested presence an intravascular aorto-iliac thrombus which confirmed sonographically. Subsequently, treatment initiated with Heparin s.c. and continued for 7 months Phenprocoumon (Marcoumar). The dosage monitored adjusted according prothrombin time, initially measured every week, later maximally biweekly. improved regression could be...