A5018764651- MicroRNA in disease regulation
- HIV, Drug Use, Sexual Risk
- Cancer-related molecular mechanisms research
- Healthcare and Venom Research
- Acupuncture Treatment Research Studies
- CRISPR and Genetic Engineering
- Traditional Chinese Medicine Studies
- Computational Drug Discovery Methods
- Insect and Pesticide Research
- Biochemical effects in animals
- Circular RNAs in diseases
- RNA modifications and cancer
- Artificial Intelligence in Healthcare
- Reproductive Biology and Fertility
- Antibiotic Resistance in Bacteria
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Pharmacological Effects of Natural Compounds
- Substance Abuse Treatment and Outcomes
- Hepatitis C virus research
- Mosquito-borne diseases and control
- RNA Research and Splicing
- Ovarian function and disorders
- Bacterial biofilms and quorum sensing
- Tannin, Tannase and Anticancer Activities
China Agricultural University
2020-2025
Beijing University of Chinese Medicine
2009-2024
Dongguan People’s Hospital
2005-2024
Capital Medical University
2018-2024
Inner Mongolia University
2022-2024
Beijing Obstetrics and Gynecology Hospital
2018-2024
Ningbo University
2013-2024
Weatherford College
2024
State Key Laboratory of Genetic Engineering
2024
Fudan University
2022-2024
Wumei Pill (WMP), a famous herbal formula, has been widely used to treat digestive system diseases in clinical practice China for centuries. We have found correlation between the indications of WMP and typical symptoms pancreatic neoplasms. However, pharmacological mechanisms still remain unknown. In present work, we network method predict its underlying complex mechanism treating Firstly, obtained relative compounds based on TCMSP database, TCM database@Taiwan TCMID database collected...
Dengue, a mosquito-borne febrile viral disease, is found in tropical and sub-tropical regions around the world. Since first occurrence of dengue was confirmed Guangdong, China 1978, outbreaks have been reported sequentially different provinces South transmitted by peridomestic Ae. albopictus mosquitoes, diplaying aegypti, fully domestic vector that transmits worldwide. Rapid uncontrolled urbanization characteristic change developing countries, which impacts greatly on habitat, human...
MicroRNAs (miRNA, miR) have been implicated as promising blood‐based biomarkers for schizophrenia patients. This study aimed to clinically validate miRNA potential biomarkers. Plasma levels of 10 miRNAs were analyzed using qPCR in a cohort 61 patients and 62 normal controls, well 25 particularly selected six‐week antipsychotic treatment course. Positive And Negative Syndrome Scale (PANSS), Global Assessment (GAS) Clinical Impression (CGI) administered assess the clinical symptoms. The...
Cutin serves as the foundational structure of plant cuticle and plays a crucial role in determining fruit development quality. However, transcriptional regulation cutin deposition by fruit-specific transcription factors remains largely unknown. This study delves into regulatory tomato (Solanum lycopersicum) SBP-box protein Colorless Non-ripening (SlCNR), primarily expressed fruits, formation. We found that CRISPR/Cas9-induced slcnr mutants exhibited thicker cuticles elevated contents total...
The wall-associated kinase (WAK) and like (WAKL) is a subfamily of receptor-like kinases associated with the cell wall, which have been suggested as sensors extracellular environment triggers intracellular signals. However, these proteins not yet comprehensively analyzed in tomato (Solanum lycopersicum L.). In this study, 11 SlWAK 18 SlWAKL genes were identified an uneven distribution 9 12 chromosomes. GUB-WAK-bind (wall-associated receptor galacturonan-binding) epidermal growth factor (EGF)...
Background This study was conducted to identify epidemiological characteristics of the first documented CHIK fever outbreak in China and evaluate effect preventive measures taken. Methodology/Principal Findings From September 1 October 29, 2010, China's occurred Xincun community Wanjiang District Dongguan city, Guangdong province; 253 case-patients were recorded, which 129 laboratory confirmed, with an attack rate 1%. Before 18th number cases remained relatively low community; from 19th...
The incidence of cervical cancer caused by human papillomavirus (HPV) infection has increased in recent years. More than half all cases are due to HPV16 and HPV18 infection, so testing is essential prevent cancer. HPV mainly carried out hospitals, but it subject time specialized medical facilities. On the other hand, home self-testing using simple diagnostics would present an attractive alternative privacy flexibility with regard place, provided sufficient sensitivity specificity can be...
Abstract Background CHIKV is a mosquito-borne emerging pathogen that has major health impact in humans tropical zones around the globe. A new variant of virus, E1-A226V caused large outbreak Indian Ocean islands and India from 2004–2007. was initially reported Dongguan region Guangdong 2010 China, another smaller found Yangjiang two weeks later. The viral agent causing outbreaks inferred to be might introduced Dongguan. To confirm hypothesis determine origin outbreaks, we described this...
Depression and anxiety are common symptoms for schizophrenia (SZ) in the early onset. This study aimed to determine whether long noncoding RNAs (lncRNAs) can be indicators diagnosing SZ nonpsychiatric hospitals.Three upregulated lncRNAs, six downregulated major depressive disorder (MDD) lncRNAs three generalized (GAD) were cross-validated 45 patients, 48 MDD 52 GAD patients 40 controls by reverse transcription-PCR.Three significantly patients. The expression of showed an opposite trend also...
To compare the prediction effects of six models based on machine learning theories, which can provide a methodological reference for predicting risk type 2 diabetes mellitus (T2DM).This study was monitoring data chronic disease factors in Dongguan residents from 2016 to 2018. The multistage cluster random sampling method adopted at each site, and 4157 people were finally selected. In initial population, we excluded individuals with more than 20% missing eventually included 4106 subjects.K...
The structure of a back propagation neural network was optimized by particle swarm optimization (PSO) algorithm, and model based on PSO algorithm constructed. By comparison with general logistic regression, the fitting performance prediction is discussed. Furthermore, risk factors related to hypertension were further explored through mean influence value construct model. In evaluation effect, root square error coefficient determination 0.09 0.29, respectively. performance, accuracy,...