A5018925615- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Enzyme Production and Characterization
- Biochemical and Structural Characterization
- Inflammatory Biomarkers in Disease Prognosis
- Venous Thromboembolism Diagnosis and Management
- Bacterial Identification and Susceptibility Testing
- Endometriosis Research and Treatment
- Uterine Myomas and Treatments
- Antimicrobial Resistance in Staphylococcus
- Hepatitis B Virus Studies
- Peptidase Inhibition and Analysis
- Angiogenesis and VEGF in Cancer
- Electrospun Nanofibers in Biomedical Applications
- Eosinophilic Disorders and Syndromes
- Protease and Inhibitor Mechanisms
- Antibiotic Resistance in Bacteria
- 3D Printing in Biomedical Research
- Gold and Silver Nanoparticles Synthesis and Applications
- Healthcare Regulation
- Blood groups and transfusion
- Antimicrobial Peptides and Activities
- Infective Endocarditis Diagnosis and Management
- Reproductive System and Pregnancy
- Antibiotic Use and Resistance
Instituto Federal do Espírito Santo
2025
Associação Fundo de Incentivo à Pesquisa
2024
Biotech (Brazil)
2017-2021
Universidade Federal de São Paulo
2005-2019
Universidade de São Paulo
2017
Colsan - Associação Beneficente de Coleta de Sangue
2011-2013
Hospital São Paulo
2004
Universidade Federal de Santa Maria
2003
Irrigated agriculture plays a crucial role in food production, especially regions where water availability is limited. In this context, plant growth regulators emerge as essential tools to optimize and development. These compounds, which can be natural or synthetic, influence physiological processes such germination, flowering, fruiting resistance environmental stresses. By promoting better use of nutrients, not only increase irrigation efficiency but also contribute the sustainability...
// Sheila Siqueira Andrade 1, 4, 5 , Joana Tomomi Sumikawa 1 Eloísa Dognani Castro 2 Fabricio Pereira Batista Edgar Paredes-Gamero Lilian Carolina Oliveira 3 Izabel Monastério Guerra Giovani Bravin Peres Renan Pelluzzi Cavalheiro Luiz Juliano Afonso Pinto Nazário Gil Facina Siu Mui Tsai Maria Luiza Vilela Oliva Manoel João Castello Girão 4 Department of Gynecology The Federal University São Paulo, Brazil Biochemistry Biophysics Charitable Association...
Breast cancer comprises clinically and molecularly distinct tumor subgroups that differ in cell histology biology show divergent clinical phenotypes impede phase III trials, such as those utilizing cathepsin K inhibitors. Here we correlate the epithelial-mesenchymal-like transition breast cells secretion with activation aggregation of platelets. Cathepsin is up-regulated proteolyze extracellular matrix contributes to invasiveness. Although proteolytically activated receptors (PARs) are by...
Increased levels of hydrogen peroxide (H2O2) can initiate protective responses to limit or repair oxidative damage. However, H2O2 signals also fine-tune growth factors and cytokines controlling cell division, differentiation, proliferation. Because 17β-estradiol (E2) plays important roles in these processes, is considered a major risk factor the development progression endometriosis, this study evaluated whether E2 has an antiapoptotic effect on stress endometrial cells combination with...
Snake venom metalloproteinases (SVMPs) belonging to P-I class are able hydrolyze extracellular matrix proteins and coagulation factors triggering local systemic reactions by multiple molecular mechanisms that not fully understood. BmooMPα-I, a SMVP from Bothrops moojeni venom, was active upon neuro- vaso-active peptides including angiotensin I, bradykinin, neurotensin, oxytocin substance P. Interestingly, BmooMPα-I showed strong bias towards hydrolysis after proline residues, which is...
The potencies of mammalian cell-derived recombinant human erythropoietin pharmaceutical preparations, from a total five manufacturers, were assessed by in vivo bioassay using standardized protocols. Eight-week-old normocythemic mice received single subcutaneous injection followed blood sampling 96 h later or multiple daily injections with 24 after the last injection. Reticulocyte counting microscopic examination was employed as end-point brilliant cresyl blue selective hemolysis methods,...
As part of a major epidemiologic study on Chagas' disease, we compared the prevalence electrocardiographic (ECG) abnormalities among 141 school children 7-12 years age and seropositive for Trypanosoma cruzi, 282 age-, sex-, school-matched seronegative in an endemic area Brazil. The ECG was 11.3% 3.5% (odds ratio = 3.5, 95% confidence interval [CI] 1.5-8.4). rate alterations 10.7% males versus 8.9% females. Complete right bundle branch block (CRBBB), which is highly suggestive disease...
An increased incidence of nosocomial and community-acquired infections caused by methicillin-resistant Staphylococcus aureus (MRSA) has been observed worldwide. The molecular characterization MRSA played an important role in demonstrating the existence internationally disseminated clones. use biology methods surveillance programs enabled tracking spread within among hospitals. These data are useful to alert infection control about potential introduction these epidemic clones their areas....
Baupain belongs to the α+β class of proteins with a secondary structure-content 44% α-helix, 16% β-sheet and 12% β-turn. The structural transition induced by pH was found be noncooperative, no important differences observed in range from 3.0 10.5. At 2.0 protein presented substantial non-native structure strong ANS binding. Guanidine hydrochloride (GdnHCl)-induced unfolding did not change significantly until 4.0 M, indicating high rigidity molecule. cooperative, as seen sigmoidal curves...
Chronic hepatitis C (CHC) has emerged as a leading cause of cirrhosis in the U.S. and across world. To understand role apoptotic pathways virus (HCV) infection, we studied mRNA protein expression patterns apoptosis-related genes peripheral blood mononuclear cells (PBMC) obtained from patients with HCV infection. The present study included 50 subjects which plasma samples were positive for HCV, but negative human immunodeficiency (HIV) or B (HBV). These cases divided into four groups...
Venous thromboembolism (VTE) is one of the most common causes cancer related mortality. It has been speculated that hypercoagulation in patients triggered by direct or indirect contact platelets with tumor cells, however underlying molecular mechanisms involved are currently unknown. Unraveling these may provide potential avenues for preventing platelet-tumor cell aggregation. Here, we investigated role protein tyrosine phosphatases functionality both healthy individuals and gastrointestinal...
AbstractAbstractA total of 1,346 Staphylococcus aureus (SA) and 498 coagulase-negative staphylococcal (CoNS) strains isolated from 11 Latin American medical centers between 2000 2001 were tested against mupirocin other antimicrobial agents by reference broth microdilution method as part the SENTRY Antimicrobial Surveillance Program. Oxacillin resistance (OR) was detected in 38.6% S. 78.1% CoNS. The overall rate to low among (3.1%; MIC ≥8 μd/ml) but significantly higher ORSA compared...