A5087055782- Drug Transport and Resistance Mechanisms
- Enzyme Production and Characterization
- Phytase and its Applications
- Natural Antidiabetic Agents Studies
- Amino Acid Enzymes and Metabolism
- Computational Drug Discovery Methods
- Pharmacological Effects and Toxicity Studies
- Protein Hydrolysis and Bioactive Peptides
- Essential Oils and Antimicrobial Activity
- Adenosine and Purinergic Signaling
- Neonatal Health and Biochemistry
- Phytochemicals and Antioxidant Activities
- Aquaculture disease management and microbiota
- Antibiotic Resistance in Bacteria
- Synthesis and biological activity
- Pharmacology and Obesity Treatment
- Biochemical Analysis and Sensing Techniques
- Hormonal Regulation and Hypertension
- Epigenetics and DNA Methylation
- Biofuel production and bioconversion
- Microbial Metabolites in Food Biotechnology
- Diet and metabolism studies
- Bioinformatics and Genomic Networks
- Reproductive biology and impacts on aquatic species
- Crystallization and Solubility Studies
University of Jeddah
2017-2024
King Saud University
2020
University of New England
2012-2018
Diabetes is a global health concern with significant implications for individuals and healthcare systems. Finding effective safe antidiabetic agents crucial the management of this chronic disease. Natural products have emerged as potential alternatives to allopathic drugs, offering vast source bioactive compounds. In study, we conducted an assessment Origanum compactum essential oil, employing two-pronged approach, i.e., experimental investigation computational docking analysis. The results...
The study evaluated the phytochemical composition of Ephedra alata and its effects on α-amylase lipase enzymes diabetic-induced liver-kidney-testes toxicities to determine anti-diabetic, anti-obesity, anti-toxic potentials plant. Obesity was induced by a high-fat fructose diet (HFFD). Various compounds were identified quantified: cafeic acid, apigenin 7-O-glucoside, apigenin, rutin, luteolin p-Coumaric acid others in EA aqueous extract (EAWE). In vitro, this showed that EAWE strongly...
The increasing challenge of antibiotic resistance requires not only the discovery new antibiotics, but also development alternative approaches. Therefore, in present study, we investigated for first time antibacterial potential phytic acid (myo-inositol hexakisphosphate, IP6), a natural molecule that is ‘generally recognized as safe’ (FDA classification), against proliferation common foodborne bacterial pathogens such Listeria monocytogenes, Staphylococcus aureus and Salmonella Typhimurium....
The biotechnological process called solid-state fermentation (SSF) was applied for hyper production of protease by using a fungal strain Aspergillus oryzae. From screening 9 different local substrates (peanut shell, wheat bran, guava leaves, sugar cane bagasse, rice polish, straw, corn reed grass, and straw), peanut shells serve as the best under optimized cultured conditions. varying physiochemical parameters such pH (2–9.5), temperature (30–52 °C), incubation time (1–10 days), inoculum...
Deltamethrin (DLM) represents one of the most commonly used pesticides. It passes through milk, vegetables, and fruits to humans or animals (veterinary drugs feeding on contaminated forage) milk; it can escape from skin blood be secreted in breast milk lactating women. is believed have neurotoxic, nephrotoxic, hepatotoxic properties. To investigate deltamethrin-induced hepatotoxicity, 64 rats were divided into eight groups. The control group did not receive any treatment. groups as follows:...
Abstract Reliance on deep learning techniques has become an important trend in several science domains including biological science, due to its proven efficiency manipulating big data that are often characterized by their non-linear processes and complicated relationships. In this study, Convolutional Neural Networks (CNN) been recruited, as one of the techniques, be used classifying predicting activities essential oil-producing plant/s through chemical compositions. The model is established...
Wissadula periplocifolia (L.) Thwaites is a traditional medicinal plant belonging to the family Malvaceae, used in folk medicine for inflamed snake bites and bee stings. The current study was designed investigate vitro antioxidant vivo anti-inflammatory hepatoprotective activities of 80% ethanol extract W. its different fractions. crude ethanolic (CEE) then serially fractionated with petroleum ether fraction (PEF), chloroform (CHF), aqueous (AQF). activity assessed using...
Epidermal Growth Factor Receptor (EGFR) is, for the most part, deregulated and over-communicated in ovarian disease, which is legitimately connected with STAT3 enactment that prompts collection of hostile to apoptotic occasions along these lines, docetaxel medicate obstruction happens. As to, expanding affectability by focusing on EGFR receptor alongside drugs one real techniques disease treatment. In this specific circumstance, utilizing atomic recreation considers, present examination...
The gene encoding Bacillus subtilis α-amylase was cloned into pET-21a (+). expression level of the recombinant enzyme 10.7-fold higher than native one (0.13 mg mL−1). (His6-rAmyKS) purified in step using Ni-NTA column affinity with a specific activity 664.28 U.mg−1. biochemical properties His6-rAmyKS were determined and compared to those non-tagged enzyme. Interestingly, differences found between two enzymes mainly for optimal temperature pH. Experimental tests molecular modeling confirmed...
Aim: This study investigates the altered expression and CpG methylation patterns of histone demethylase KDM8 in hepatocellular carcinoma (HCC), aiming to uncover insights promising diagnostics biomarkers. Materials & methods: Leveraging TCGA-LIHC multi-omics data, we employed R/Bioconductor libraries Cytoscape analyze construct a gene correlation network, LASSO regression develop an HCC-predictive model. Results: In HCC, downregulation is correlated with CpGs hypermethylation. Differential...
The Bacillus subtilis US191 strain producing highly thermostable β-mannanase was previously selected as potential probiotic candidate for application feed supplement in poultry industry. Initially, the level of extracellular production by this 1.48 U ml-1 . To improve enzyme titer, present study undertaken to optimize fermentation conditions through experimental designs and valorization agro-industrial byproducts. Using Plackett-Burman design, submerged fermentation, a set 14 culture...
The growth of the aquafeed sector is highly dependent upon availability fish feed with a balanced nutritional composition. use prebiotics and probiotics can be an effective solution to increase bioavailability components. In this study, we evaluated effect dietary supplementation β-propeller phytase (0, 600, 1200, 1800 2400 U/kg) from Bacillus mannan oligosaccharide (MOS) 2, 4 8 g/kg) on performance nutrient digestibility Nile tilapia over 45 days. findings showed that adding significantly...