A5070082941- Cellular Mechanics and Interactions
- 3D Printing in Biomedical Research
- Advanced biosensing and bioanalysis techniques
- Wound Healing and Treatments
- Graphene and Nanomaterials Applications
- Liver Disease Diagnosis and Treatment
- Immune cells in cancer
- Renal and related cancers
- Organ Donation and Transplantation
- Drug-Induced Hepatotoxicity and Protection
- Optical Coherence Tomography Applications
- Neurobiology and Insect Physiology Research
- Nanoplatforms for cancer theranostics
- Pluripotent Stem Cells Research
- Polymer Surface Interaction Studies
- Biochemical Analysis and Sensing Techniques
- Advanced Biosensing Techniques and Applications
- Orbital Angular Momentum in Optics
- Silk-based biomaterials and applications
- Liver Diseases and Immunity
- Electromagnetic Fields and Biological Effects
- Extracellular vesicles in disease
- Mesenchymal stem cell research
- Muscle Physiology and Disorders
- Hepatitis B Virus Studies
Korea University Medical Center
2023-2025
Korea University
2022-2024
University Medical Center
2023
Nanyang Technological University
2020-2022
Keimyung University
2018
Abstract Extracellular matrix (ECM) proteins containing cell‐attachable Arg‐Gly‐Asp (RGD) sequences exhibit variable bridging and non‐bridging in fibronectin‐collagen laminin‐collagen complexes that can regulate inflammation, tissue repair, wound healing. In this study, linking molecule‐mediated conjugation of 1D magnetic nanocylinders (MNCs) to material surfaces pre‐decorated with gold nanospheres (GNSs) is performed, thereby yielding RGD‐coated MNCs (RGD‐MNCs) over GNSs (RGD‐GNSs) a state....
The native extracellular matrix is continuously remodeled to form complex interconnected network structures that reversibly regulate stem cell behaviors. Both regulation and understanding of its intricate dynamicity can help modulate numerous However, neither these has yet been achieved due the lack designing modeling such with dynamic controllability. Here we report modularity-based mathematical matrix-emulating ligand inter-cluster connectivity using graph theory. Increasing anisotropy...
Abstract An effective wound management strategy needs accurate assessment of status throughout the whole healing process. This can be achieved by examining molecular biomarkers including proteins, DNAs, and RNAs. However, existing methods for quantifying these such as immunohistochemistry quantitative polymerase chain reaction are usually laborious, resource‐intensive, disruptive. article reports development utilization mRNA nanosensors (i.e., NanoFlare) that topically applied on cutaneous...
Extracorporeal shockwave therapy (ESWT) can induce wound healing by increasing tissue microcirculation. However, studies on the effect of ESWT enhancing microcirculation in diabetic foot ulcer (DFU), particularly when increases after application, are still lacking. Therefore, we aimed to examine effectiveness promoting DFU patients a time-dependent manner. We included 50 feet 25 with type 2 diabetes mellitus and Wagner grade I II this study. The affected were used as group unaffected...
Macrophages can be polarized to M1 or M2 type with pro-inflammatory anti-inflammatory properties. Nanoparticles have recently been found a promising platform polarize macrophages desired phenotypes. This article explores the usage of cell membrane-derived nanoparticles (nanoghosts) for reprogramming macrophages. The efficacy and efficiency this technology are examined via cytokine analysis immunostaining nanoghost-treated cells. We find that several cytokines/chemokines highly expressed on...
Drug-induced nephrotoxicity represents an important cause of acute kidney injury with associated patient morbidity and mortality is often responsible for termination drug development, after extensive resource allocation. We have developed a human tubuloid system that phenocopies, in 3D culture, proximal tubules, primary site most nephrotoxicants. Traditional end point assays are performed on 2D cultures cells lost their differentiated phenotype. Herein, we pair Nanoflare (NF) mRNA...
Active bubble-generating microneedles (MNs) upon skin interstitial fluid (ISF) contact facilitate deeper and more efficient delivery of intradermal therapeutics. However, MN platforms are sensitive to moisture, which limits their variety load various functional drugs. This article presents a frozen immersion method that facilitates both hydrophobic hydrophilic drug loading onto MNs without compromising properties. The formed bubbles ISF induce distinct vortex flow produces propulsion force...
Macrophage Adhesions In article number 2215166, Heemin Kang, Jong Seung Kim, and co-workers report the magnetic control of bridging non-bridging between RGD-coated nanomaterials non-magnetic RGD nanomaterials. This variable in situ temporally modulates recruitment, integrin binding, adhesion structure assembly host macrophages that determine their functional pro-inflammatory or pro-healing immunoregulation.
Abstract Obesity has been increasing in many regions of the world, including Europe, USA, and Korea. To manage obesity, we should consider it as a disease apply therapeutic methods for its treatment. Molecular approaches obesity management involve regulating biomolecules such DNA, RNA, protein adipose-derived stem cells to prevent be fat cells. Multiple factors are believed play role differentiation, with one most effective factor is Ca 2+ . We recently reported that electromagnetic...
Abstract Graph theory has been widely used to quantitatively analyze complex networks of molecules, materials, and cells. Analyzing the dynamic structure extracellular matrix can predict cell‐material interactions but not yet demonstrated. In this study, graph theory‐based mathematical modeling RGD ligand inter‐relation is demonstrated by differentially cutting off RGD‐to‐RGD interlinkages with flexibly conjugated magnetic nanobars (MNBs) tunable aspect ratio. The are less effectively cut...
Abstract Obesity has been increasing in many regions of the world, including Europe, USA, and Korea. To manage obesity, we should consider it as a disease apply therapeutic methods for its treatment. Molecular approaches obesity management involve regulating biomolecules such DNA, RNA, protein adipose-derived stem cells to prevent be fat cells. Multiple factors are believed play role differentiation, with one most effective factor is Ca 2+ . In particular, plays an important different stages...