A5013368549- Stress Responses and Cortisol
- Circular RNAs in diseases
- Cancer-related gene regulation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Tryptophan and brain disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Adipose Tissue and Metabolism
- Fire dynamics and safety research
- Alzheimer's disease research and treatments
- Evacuation and Crowd Dynamics
- RNA Research and Splicing
- Autophagy in Disease and Therapy
- Cancer Immunotherapy and Biomarkers
- Water Systems and Optimization
- Methane Hydrates and Related Phenomena
- Rheumatoid Arthritis Research and Therapies
- Fire Detection and Safety Systems
- Circadian rhythm and melatonin
- Birth, Development, and Health
- Pancreatic and Hepatic Oncology Research
- S100 Proteins and Annexins
- Epigenetics and DNA Methylation
- Heat shock proteins research
Yangzhou University
2024-2025
University of Science and Technology of China
2021-2025
Tianjin Energy Investment Group (China)
2025
Wuhan University of Technology
2024
Nanjing Medical University
2021-2022
Southeast University
2019-2020
Circular RNAs (circRNAs) are expressed at high levels in the brain and involved various CNS diseases. However, potential role of circRNAs ischemic stroke-associated neuronal injury remains largely unknown. Here, we investigated important functions circRNA <i>TLK1</i> (circTLK1) this process. The circTLK1 were significantly increased tissues a mouse model focal cerebral ischemia reperfusion. Knockdown decreased infarct volumes, attenuated injury, improved neurological deficits. Furthermore,...
BackgroundCircular RNAs (circRNAs) have been reported to be involved in central nervous system (CNS) diseases and a close connection with neuronal development. However, the role of circRNAs neural stem cell (NSC) differentiation treatment ischaemic stroke remains unknown.MethodsIschaemic was induced mice using transient middle cerebral artery occlusion (tMCAO). NSCs were transducted circHIPK2 siRNA (si-circHIPK2-NSCs) or vehicle control (si-circCon-NSCs) microinjected into lateral ventricle...
77 B ackground: Currently, the standard first-line/second-line treatment for advanced colorectal cancer with RAS mutations is chemotherapy combined bevacizumab. Patients confirmed maintenance therapy can effectively improve progression-free survival, patient quality of life. Therefore, this study aims to evaluate efficacy and safety bevacizumab mFOLFOX6/FOLFIRI sequential capecitabine as conversion RAS-mutated cancer. M ethods: This an open-label, single-center in previously untreated...
Abstract Background Ascorbic acid can regulate the function of immune system. This study aimed to investigate underlying mechanisms ascorbic in plasma cell differentiation and rheumatoid arthritis (RA). Methods Mice were intraperitoneally injected with either or an equivalent volume phosphate-buffered saline (PBS). To elucidate effects on arthritis, we utilized a collagen induced mouse model (CIA). antibody response, mice immunized (4-Hydroxy-3-nitrophenylacetyl)-Ficoll (NP-Ficoll)...
Ewing sarcoma (ES) is a cancer that may originate from stem mesenchymal or neural crest cells and highly prevalent in children adolescents. In recent years, targeted therapies against immune-related genes have shown good efficacy variety of cancers. However, effective targets for immunotherapy ES are yet to be developed. our study, we first identified the immune-associated differential hub gene NPM1 by bioinformatics methods as differentially expressed gene, then validated it using real...
In recent years, due to the diversity of fire scenes in ports and ships, problem command is complicated. case power failure, original platform extinguishing system will not be able used normally, or resources carried by ship when it on cannot used. traditional firefighting ability research, there no clear measure ability, resulting inaccurate calculation results. By corresponding quantity composition for study capability, combination dynamics simulation software PyroSim2020 a model that...
Recent studies have found that 5-methylcytosine (m5C) modulators are associated with the prognosis and treatment of cancer. However, relevance m5C in sarcoma tumour microenvironment is unclear.We selected 15 regulators performed unsupervised clustering to identify modification patterns differentially expressed genes phenotype The Cancer Genome Atlas (TCGA) sarcomas. extent immune cell infiltration different groups was explored using single-sample gene set enrichment analysis estimation...