A5060020325- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- HIV/AIDS Research and Interventions
- Hepatitis C virus research
- Virology and Viral Diseases
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Animal Virus Infections Studies
- Hepatitis B Virus Studies
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Full-Duplex Wireless Communications
- Polyomavirus and related diseases
- Cytomegalovirus and herpesvirus research
- Hepatitis Viruses Studies and Epidemiology
- Viral Infectious Diseases and Gene Expression in Insects
- SARS-CoV-2 and COVID-19 Research
- Bacterial Infections and Vaccines
- Infectious Encephalopathies and Encephalitis
- Liver Disease Diagnosis and Treatment
- Energy Harvesting in Wireless Networks
- Viral Infections and Vectors
- Virus-based gene therapy research
- Pneumocystis jirovecii pneumonia detection and treatment
- Advanced Biosensing Techniques and Applications
Université de Caen Normandie
2005-2024
Université de Rouen Normandie
2013-2024
Normandie Université
2013-2024
Inserm
2022-2024
Centre Hospitalier Universitaire de Rouen
2013-2019
Centre de Physiopathologie de Toulouse-Purpan
2018
Institute for Research and Innovation in Biomedicine
2013-2017
Institut de Recherche et d’Innovation
2013-2016
Hôpital Charles-Nicolle
2012-2016
Institut Pasteur
2009-2011
Abstract The human coronavirus NL63 (HCoV-NL63) was first identified in the Netherlands, and its circulation France has not been investigated. We studied HCoV-NL63 infection hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 specimens for HCoV-NL63. Of samples, 28 (9.3%) were positive highest prevalence found February (18%). main symptoms fever (61%), rhinitis (39%), bronchiolitis digestive problems (33%), otitis (28%),...
The 2 groups of human coronaviruses (HCoVs) represented by the prototype strains HCoV 229E and OC43 are mostly known as viruses responsible for common cold syndrome. HCoVs difficult to detect, epidemiological data rare. From October 2000 through April 2001, we tested 1803 respiratory samples reverse-transcriptase polymerase chain reaction. 8 February 27 March was detected in obtained from 30 (6%) 501 patients. other were syncytial virus (6.1%), parainfluenza 3 (1%), influenza A (7.8%), B...
Polyomaviruses KI (KIPyV) and WU (WUPyV) were recently identified, mainly in respiratory specimens from children. Among 200 patients with disorders admitted to Saint Louis Hospital, Paris, France, KIPyV was detected 8% WUPyV 1%. significantly more frequent among human stem cell transplant (17.8% vs. 5.1%; p = 0.01).
BK virus (BKV)-associated diseases in transplant recipients are an emerging issue. However, identification of the various subtypes/subgroups is a long and delicate process on basis currently available data. Therefore, we wanted to define simple effective one-step strategy for characterizing all strains from VP1 gene sequence. Based analysis 199 complete DNA sequences, phylogenetic trees, alignments, isolated polymorphisms were used distinguishing 12 different subtypes/subgroups. subtypes...
Abstract Polyomaviruses KI (KIPyV) and WU (WUPyV) were recently identified, mainly in respiratory specimens from children. Among 200 patients with disorders admitted to Saint Louis Hospital, Paris, France, KIPyV was detected 8% WUPyV 1%. significantly more frequent among human stem cell transplant (17.8% vs. 5.1%; p = 0.01).
Objective: To evaluate the quantification performance of new Cepheid GeneXpert HIV-1 viral load assay, on a wide panel variants. Methods: Clinical was evaluated relative to Abbott RealTime assay 285 seropositive samples selected cover assays range (40 copies/mL–10,000,000 copies/mL), and included RNA undetectable or detected samples. The comprised 120 subtype B, 150 non-B, 15 nontypable clinical samples; serial dilutions 18 supernatants representative divergent viruses groups N, O, P were...
Objective: Despite the genetic divergence between HIV-1 groups M and O, M/O intergroup recombinants were reported. Actually, there is no data on transmissibility of such recombinant forms. During a surveillance HIV diversity in Cameroon, we investigated possible direct transmission an virus HIV-infected couple. Methods: Consecutive samples obtained from couple analysed for detection dual O infections, Analyses performed using serological molecular algorithm based serotyping group-specific...
Due to the prevalence of HIV-1 group M and endemicity O infections in Cameroon, patients may be infected with both viruses and/or HIV-1/MO recombinant forms. Such atypical deleterious terms diagnosis therapeutic management due high divergence HIV-1/O. The aim this study was identify prospectively such Cameroon.Based on serological screening by env-V3 serotyping a molecular strategy using group-specific (RT)-PCRs, we identified 10 Cameroonian harboring three different profiles infection: (1)...
Minority resistant variants of human immunodeficiency virus type 1 (HIV-1) could influence the virological response to treatment based on nonnucleoside reverse transcriptase inhibitors (NNRTIs). Data minority rilpivirine-resistant are scarce. This study used next-generation sequencing (NGS) identify patients harboring nucleos(t)ide and NNRTIs assess their (VR).All subjects, 541 HIV-1-infected started a first-line regimen containing rilpivirine. VR was defined as HIV-1 RNA load <50 copies/mL...
ABSTRACT The pretherapeutic presence of protease inhibitor (PI) resistance-associated variants (RAVs) has not been shown to be predictive triple-therapy outcomes in treatment-naive patients. However, they may influence the outcome patients with less effective pegylated interferon (pegIFN)-ribavirin (RBV) backbones. Using hepatitis C virus (HCV) population sequence analysis, we retrospectively investigated prevalence baseline nonstructural 3 (NS3) RAVs a multicenter cohort poor IFN-RBV...
Rapid tests for HIV testing are essential tools to achieve the 90-90-90 target of World Health Organization. Many available, some directly from websites. Evaluation performance rapid tests, under close real-life usage, is therefore needed ensure accurate diagnosis in context recommendation their more widespread use.Nine third- (3G) or fourth-generation (4G) screening self-tests (two bought on websites), were evaluated an extensive panel 200 HIV-negative and 312 HIV-positive samples,...
To describe integrase strand transfer inhibitor (INSTI) resistance profiles and factors associated with in antiretroviral-naive -experienced patients failing an INSTI-based regimen clinical practice.Data were collected from INSTI-containing a multicentre French study between 2014 2017. Failure was defined as two consecutive plasma viral loads (VL) >50 copies/mL. Reverse transcriptase, protease coding regions sequenced at baseline failure. INSTI resistance-associated mutations (RAMs) included...
Fostemsavir belongs to the new class of attachment inhibitors (AIs); it inhibits entry HIV into CD4+ T-lymphocytes by blocking conformational changes in gp120. This is a promising AI, but previous phenotypic data showed that genetically divergent HIV-1 group O could present natural resistance this drug. These were obtained from only two strains, which are not representative high intra-group genetic diversity. Moreover, no available concerning other groups (N and P). To further investigate...
A number of paramyxoviruses are responsible for acute respiratory infections in children, elderly and immuno-compromised individuals, resulting airway inflammation exacerbation chronic diseases like asthma. To understand the molecular pathogenesis these infections, we searched cellular targets virulence protein C human parainfluenza virus type 3 (hPIV3-C). We found that hPIV3-C interacts directly through its C-terminal domain with STAT1 GRB2, whereas proteins from measles or Nipah viruses...
Human immunodeficiency virus (HIV) load is the main marker used to monitor antiviral treatment efficacy and resistance. We report a case of underquantification HIV type 1 (HIV-1) RNA in plasma cerebrospinal fluid from an HIV-1 subtype G-infected woman, leading delayed diagnosis encephalitis emergence drug
Human coronavirus OC43 (HCoV-OC43) causes acute, self-limited respiratory infections. A close relationship between bovine coronaviruses (BCoVs) and HCoV-OC43 has recently been demonstrated. This study includes seven clinical, non-cell culture-adapted, contemporary strains detected in France 2003. By using RT-PCR clonal sequencing of the S1 gene HCoV-OC43, inter-variant heterogeneity circulating was studied intra-variant diversity assessed by investigation a quasispecies cloud. paper brings...
Background: The broad genetic divergence of HIV-1/O relative to HIV-1/M has important implications for diagnosis, monitoring and treatment. Despite this divergence, some HIV-1/M+O dual infections HIV-1/MO recombinant forms have been reported, mostly in Cameroon, where both groups are prevalent. Here, we describe the characteristics such detected France 10 new patients, discuss their biological clinical practice, owing presence group O species. Methods: French National Reference Centre HIV...