A5067338619- Bacterial Identification and Susceptibility Testing
- Microscopic Colitis
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Adolescent and Pediatric Healthcare
- Gut microbiota and health
- Alcohol Consumption and Health Effects
- Liver Disease and Transplantation
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Treatments and Studies
- Organ Transplantation Techniques and Outcomes
- Eosinophilic Esophagitis
- Clostridium difficile and Clostridium perfringens research
- Cancer Immunotherapy and Biomarkers
- Pregnancy and Medication Impact
- Intraperitoneal and Appendiceal Malignancies
- Hepatitis C virus research
- Colorectal Cancer Surgical Treatments
- Immune Cell Function and Interaction
- Eicosanoids and Hypertension Pharmacology
- Celiac Disease Research and Management
- Mycobacterium research and diagnosis
Northwestern University
2017-2022
Emory University
2016-2018
Children's Healthcare of Atlanta
2016-2017
Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract that associated with changes in gut microbiome. Here, we sought to identify strain-specific functional correlates IBD outcomes.We performed metagenomic sequencing monthly stool samples from 20 patients and 12 controls (266 total samples). These were taxonomically profiled MetaPhlAn2 functionally using HUMAnN2. Differentially abundant species identified MaAsLin pangenome haplotypes analyzed...
Gut microbiome dysbiosis has been demonstrated in subjects with newly diagnosed and chronic inflammatory bowel disease (IBD). In this study we sought to explore longitudinal changes ascertain associations between markers of activity treatment outcome. We performed a prospective cohort 19 treatment-naïve pediatric IBD 10 healthy controls, measuring fecal calprotectin assessing the gut via repeated stool samples. Associations clinical characteristics were tested using generalized estimating...
Alcohol-related liver disease (ALD) is the leading indication for transplantation in United States, but disparities women with ALD exist. We sought to characterize trends hospitalizations and mortality among women. Using National Inpatient Sample, we evaluated non-ALD discharges from 2003 2017. Multivariable logistic regression was used evaluate mortality. increased more rapidly women, alcohol hepatitis (AH) rising most. When stratified by age sex, changes alcohol-related cirrhosis (AC) AH...
Checkpoint inhibitors are immune-stimulatory antibodies that have transformed the management and prognosis of individuals with metastatic melanoma other cancers. inhibitor-induced colitis is an increasingly recognized immune-related adverse event shares many same phenotypical, serological, histological characteristics both Crohn's disease ulcerative colitis, suggesting checkpoint may represent a new inflammatory bowel phenotype. We report 73-year-old man who developed ipilimumab-induced...
Infliximab (IFX) is an effective treatment for the management of moderate to severe inflammatory bowel disease (IBD). Low-serum IFX levels are associated with development antibodies (ATI), which subsequently clinical relapse and increased morbidity. The primary purpose this study examine relation between dose interval level. Secondary goal evaluate level ATI in a pediatric IBD population.We performed retrospective chart review all children diagnosed treated at tertiary care center. We our...
Inflammatory bowel disease (IBD) mainly consists of Crohn's (CD) and ulcerative colitis (UC). About 10%–15% patients with IBD cannot be firmly diagnosed CD or UC; hence, they are initially as inflammatory unclassified (IBD-U). Having a firm diagnosis is clearly preferred to guide treatment choices, better understanding the nature IBD-U required. We performed an analysis subset pediatric subjects from inception cohort enrolled in prospective multicenter study (the RISK study). Initial 2-year...
Abstract Backgrounds Recent studies have identified the role of serologic markers in characterizing disease phenotype, location, complications, and severity among Northern Europeans (NE) with Crohn’s (CD). However, very little is known about serology CD African Americans (AA). Our study explored relationship between phenotype AA CD, while controlling for genetic ancestry. Methods AAs were enrolled as participants through multicenter collaborative efforts. Serological levels IgA...