A5101596583- Heavy Metal Exposure and Toxicity
- Animal Nutrition and Physiology
- Selenium in Biological Systems
- Gut microbiota and health
- Trace Elements in Health
- RNA modifications and cancer
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Infant Nutrition and Health
- Cancer-related molecular mechanisms research
- Arsenic contamination and mitigation
- Effects of Environmental Stressors on Livestock
- Probiotics and Fermented Foods
- Gout, Hyperuricemia, Uric Acid
- Animal Behavior and Welfare Studies
- Silymarin and Mushroom Poisoning
- Magnesium in Health and Disease
- Pregnancy and Medication Impact
- Epigenetics and DNA Methylation
- Food and Agricultural Sciences
- Nutrition and Health in Aging
- Vitamin C and Antioxidants Research
- Cancer, Hypoxia, and Metabolism
- Quinazolinone synthesis and applications
- Phytoestrogen effects and research
Chinese Academy of Agricultural Sciences
2019-2024
Ministry of Agriculture and Rural Affairs
2019-2024
Puer University
2024
Feed Research Institute
2023-2024
Boxing People's Hospital
2024
Institute of Animal Sciences
2019-2021
China Agricultural University
2013-2020
Chongqing Medical University
2009-2016
Chongqing Medical and Pharmaceutical College
2009-2011
Shenyang Medical College
2009-2010
Rumen microbes play an important role in ruminant energy supply and animal performance. Previous studies showed that yak (Bos grunniens) rumen microbiome fermentation differ from other ruminants. However, little is understood about the features of make adapted to their unique environmental dietary conditions. This study was investigate metabolome understand how adapt coarse forage harsh environment Qinghai-Tibetan plateau. Nine female Qaidam yellow cattle taurus), 9 dzomo (hybrids yak)...
Abstract Background The immune system is one aspect of health that affected by dietary selenium (Se) levels and selenoprotein expression. Spleen an important organ the body, which directly involved in cellular immunity. However, there are limited reports on Se spleen health. Therefore, this study established a Se-deficient pig model to investigate mechanism deficiency-induced splenic pathogenesis. Methods Twenty-four pure line castrated male Yorkshire pigs (45 days old, 12.50 ± 1.32 kg, 12...
Bacillus licheniformis (B. Licheniformis) has been considered to be an effective probiotic maintain gut health and boost productivity in the pig industry, but there is no complete understanding of its mechanisms. We determined whether weaned piglets exposed BL-S6 (probiotic) had altered intestinal barrier function or microbiota composition. In our study, 108 (54 barrows 54 gilts) were divided equally into three groups, each with six pens piglets/pen, fed a basal diet supplemented without...
Silybin (Si) is the main element of silymarin isolated from seeds Silybum marianum L. Gaernt., which has superior antioxidant properties. However, protective role Si in maintaining liver health under oxidative stress remains ambiguous. This study aimed to investigate underlying mechanism beneficial effect dietary against hepatic injury induced by paraquat (PQ) weaned piglets. A total 24 piglets were randomly allocated four treatments with six replicates per treatment and 1 piglet replicate:...
Flaxseed meal (FSM) is a byproduct of flaxseed oil extraction which has rich nutritional value and can be used as high-quality new protein ingredient. However, the anti-nutrient factor (ANF) in FSM restricts its potential application feed. The strategy microbial fermentation highly effective approach to reducing ANF enhancing feeding value. evaluation fermented (FFSM) growing pigs not yet been conducted. Thus, purpose this study was investigate FFSM comparison effect treatment on improving...
Gouty arthritis is characterized by intense, acute inflammatory reactions that occur in response to articular deposits of monosodium urate crystals. In this study we have assessed the effects flavonoid, quercetin, on crystal-induced inflammation rats, an experimental model for gouty arthritis.Gouty was induced intra-articular injection crystal suspension inside ankle joint rat right hind limb. Circumference at 2, 4, 8, 12, 24, and 48 h after injection. Histopathological analysis synovial...
Pork produced by outdoor-reared pigs raised mostly on alfalfa pastures attracts increasing population of consumer from most the world. In China, were with alfalfa-containing diets to seek for good quality pork. However, influence dietary involving high level insoluble fiber (IDF) pig intestinal luminal microbiota composition remains unclear. The objective this study was investigate effects and short chain fatty acids (SCFA) production, gene expressions involved in SCFA sensing, transporting...
Abstract Selenium (Se) is closely associated with kidney disease, and renal injury often occurs together hyposelenemia. This study was designed to reveal the mechanism underlying induced by Se deficiency in pigs. Twenty-four castrated male Yorkshire pigs were divided into two groups fed either a Se-deficient diet (0.007 mg per kg) or Se-adequate (0.3 kg). Serum samples collected at 16th week of trial, processed, analyzed for serum biochemistry, concentration, index markers, histology,...
Fucoidan (FC) is known for its antioxidant properties, but it has unclear effects and mechanisms on weaned piglets. Two experiments were conducted to determine the optimal FC dosage in piglet diets protective effect against lipopolysaccharide (LPS)-induced oxidative stress. In experiment one, 24 low weight piglets randomly assigned four dietary treatments: a basal diet (FC 0), or supplemented with 150 150), 300 300), 600 mg/kg 600). two, 72 low-weaning allocated into (CON), of fucoidan added...
Abstract Oxidative stress significantly contributes to heart disease, and thus might be a promising target for ameliorating failure. Mounting evidence suggests that selenium has chemotherapeutic potential treating disease due its regulation of selenoproteins, which play antioxidant regulatory roles. stress-induced cardiomyocyte cell cycle arrest the loss cardiomyocytes during The protective effects mechanism against oxidative in warrant further study. H9c2 rat cardiomyoblast cells were...
To better understand the effect of arsenic on central nervous system by prenatal and early life exposure, oxidative stress neurotransmitter metabolic enzymes were determined in offspring rats' brain cortex hippocampus. Forty-eight pregnant rats randomly divided into four groups, each group was given free access to drinking water that contained 0, 10, 50, 100 mg/L NaAsO(2) from gestation day 6 (GD 6) until postnatal 42 (PND 42). Once pups weaned, they started drink same (As)-containing as...
The aim of this experiment is to evaluate the effects adding porous zinc oxide, plant polyphenols, and their combination diets without antibiotics high-dose oxide on growth performance, diarrhea incidence, intestinal morphology, microbial diversity weaned piglets. A total 150 Duroc × Landrace Large White piglets were allocated one five in a randomized complete block design with six replicates per replicate. experimental period was 42 d, divided into two feeding stages: pre-starter (0–14 d)...
Abstract Objective Breast cancer (BC) is the most prevalent malignancy in women worldwide. Our study aimed to investigate expression and biological effect of miR‐186 BC. Methods Expression was determined by quantitative reverse transcription PCR. Kaplan‐Meier curves were calculated for survival data analysis. Functional assays performed 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide wound healing assay. Protein analyzed Western blot. Results downregulated BC tissues cells....
The current study was carried out to determine effects of dietary protein source and crude (CP) level on carcass characteristics, meat quality, muscle amino acid (AA) profile in finishing gilts. experiment designed as a 2 × factorial arrangement with two sources proteins (cottonseed meal, CSM vs. soybean SBM) levels CP (12 % 14 %, as-fed basis). Seventy-two crossbred gilts (89.5 ± 0.9 kg) were allotted one four treatments randomized complete block design for period 28 d. All diets formulated...
Mechanism controlling myo-adipogenic balance in skeletal muscle is of great significance for human dysfunction and myopathies as well livestock meat quality. In the present study, two cell subpopulations with particular potency adipogenic or myogenic differentiation were isolated from neonatal porcine longissimus dorsi using preplate method to detect mechanisms underlying distinct fate commitment cells muscle. Both share a common surface expression profile CD29+CD31-CD34-CD90+CD105+,...
Oxidative stress is the major incentive for intestinal dysfunction in weaned piglets, which usually leads to growth retardation or even death. Silybin has caught extensive attention due its antioxidant properties. Herein, we investigated effect of dietary silybin supplementation on performance and determined protective paraquat (PQ)-induced oxidative damage microflora dysbiosis piglets. In trial 1, a total one hundred twenty healthy piglets were randomly assigned into five treatments with...
This study was conducted to investigate the effects of dietary supplementation with stimbiotics (STB) on growth performance, diarrhoea incidence, plasma antioxidant capacity, immunoglobulin concentration and hormone levels, faecal microorganisms in weaned piglets. Compared control (CT) group, addition STB improved body weight (BW) piglets days 28 42 (p < 0.05) increased daily gain feed intake from 14-28 throughout trial period 0.05). Correspondingly, insulin-like factor 1 (IGF-1) level day...
Abstract Dietary protein limitation (PL) is not only beneficial to human health but also applied minimize nitrogen excretion in livestock production. However, the impact of PL on intestinal physiology largely unknown. In this study, we identified 5275 quantitative proteins using a porcine model which pigs suffered PL. A total 202 |log 2 fold-change| > 1 were taken as differentially expressed and subjected functional pathway enrichment analysis reveal proteomic alterations jejunal mucosa....
Abstract Background Skeletal muscle is a complex and heterogeneous tissue accounting for approximately 40% of body weight. Excessive ectopic lipid accumulation in the fascicle would undermine integrity skeletal humans but endow with marbling-related characteristics farm animals. Therefore, balance myogenesis adipogenesis great significance homeostasis. Significant DNA methylation occurs during adipogenesis; however, pattern myogenic adipogenic precursors derived from remains unknown yet....
Stimbiotic supplementation may provide an innovative feed additive solution to accelerate the proliferation of beneficial fiber-degrading bacteria in distal intestine and utilization dietary fiber. Optimal fiber has multiple benefits for gut health nutrient utilization. This study was conducted evaluate late gestation lactation performance, plasma, colostrum, milk immunoglobulin (IgA, IgG, IgM) concentrations, anti-inflammatory antioxidant biomarkers plasma sows fed with or without a...
In the weaning period, piglets often face oxidative stress, which will cause increased diarrhea and mortality. Genistein, a flavonoid, is extracted from leguminous plants, possesses anti-inflammatory antioxidative bioactivities. However, little known about whether genistein could attenuate stress that occurs in porcine intestinal epithelial cells (IPEC-J2). Herein, this experiment was carried out to investigate protective effects of IPEC-J2 model. Our results disclosed H2O2 stimulation...