A5035276450- Renal and related cancers
- Pluripotent Stem Cells Research
- Seed and Plant Biochemistry
- Renal cell carcinoma treatment
- Microbial Metabolites in Food Biotechnology
- Renal Diseases and Glomerulopathies
- Thermodynamic and Structural Properties of Metals and Alloys
- CRISPR and Genetic Engineering
- Polysaccharides and Plant Cell Walls
- Genetic and Kidney Cyst Diseases
- Organ Donation and Transplantation
- Plant Molecular Biology Research
- RNA regulation and disease
- RNA modifications and cancer
- Food composition and properties
- RNA Research and Splicing
- Genetics and Plant Breeding
- Chemical Thermodynamics and Molecular Structure
- Connexins and lens biology
- Plant Reproductive Biology
- Plant tissue culture and regeneration
- Tissue Engineering and Regenerative Medicine
- Epigenetics and DNA Methylation
- Advanced Physical and Chemical Molecular Interactions
- Proteoglycans and glycosaminoglycans research
The University of Queensland
2020-2022
Hospital for Sick Children
2019
Kumamoto University
2013-2018
University of Dhaka
2002-2013
Glomerular podocytes express proteins, such as nephrin, that constitute the slit diaphragm, thereby contributing to filtration process in kidney. development has been analyzed mainly mice, whereas analysis of human kidney minimal because limited access embryonic kidneys. We previously reported induction three-dimensional primordial glomeruli from induced pluripotent stem (iPS) cells. Here, using transcription activator–like effector nuclease-mediated homologous recombination, we generated...
Mutations in the NPHS1 gene, which encodes NEPHRIN, cause congenital nephrotic syndrome, resulting from impaired slit diaphragm (SD) formation glomerular podocytes. However, methods for SD reconstitution have been unavailable, thereby limiting studies field. In present study, we established human induced pluripotent stem cells (iPSCs) a patient with an missense mutation, and reproduced process using iPSC-derived kidney organoids. The mutant NEPHRIN failed to become localized on cell surface...
Induced pluripotent stem cells (iPSC) derived from healthy individuals are important controls for disease-modeling studies. Here we apply precision health to create a high-quality resource of control iPSCs. Footprint-free lines were reprogrammed four volunteers the Personal Genome Project Canada (PGPC). Multilineage-directed differentiation efficiently produced functional cortical neurons, cardiomyocytes and hepatocytes. Pilot users demonstrated versatility by generating kidney organoids, T...
Two of the most widely and intensively cultivated jute species, Corchorus capsularis olitorius, suffer severely from a stem rot disease caused by fungus Macrophomina phaseolina. Wild C. trilocularis, shows resistance to this pathogenic fungus. In study, technique differential display was applied identify genes which are differentially expressed, under both infected un-infected conditions, between trilocularis olitorius var O-72. xyloglucan endotransglycosylase/hydrolase (XTH) designated...
There is an urgent need for developing crops with greater tolerance to environmental stresses. This even more important fiber crops, which are being pushed the marginal low-productive lands in order make room food crops. Jute source of a highly versatile and environmentally friendly natural fiber, second only cotton terms production variety uses. In this study, we used tissue culture independent method introducing CMV 35S promoter driven katE gene from Escherichia coli K12 into popular jute...
The mite is considered as one of the major limiting factors jute production in Bangladesh. So it essential to select genotypes with desired resistance allele combination using DNA markers. Eighty-eight SSR primers were used screen resistant and sensitive parents. Among them only twenty-one primer pairs showed polymorphism. A genetic linkage map was constructed these polymorphic hundred fifty F2 populations, derived from a cross between markers J-170 HK-89 have been mapped at 34.1 cM 35.4 cM,...
Sulfate is a key anion that required for range of physiological functions within the brain. These include sulfonation extracellular proteoglycans to facilitate local growth factor binding and regulate shape morphogen gradients during development. We have previously shown mice lacking one allele sulfate transporter Slc13a4 exhibit reduced transport into brain, deficits in social behaviour, performance learning memory tasks, abnormal neurogenesis ventricular/subventricular zone lining lateral...
A leucine-rich repeat-containing protein kinase (LRR-PK) gene has been identified in Corchorus capsularis. This gene, named CcLRR-RLK1, is 3032 bp long and encodes a composed of 958 amino acid residues. The deduced peptide contains 3 distinctive domains: transmembrane domain, 5 motifs, serine/threonine domain. Expression analysis indicated that the reduced by several environmental stresses including high salt, fungus, abscisic acid, suggesting its possible involvement multiple stress...
Abstract Objective Sulfation is an essential physiological process that regulates the function of a wide array molecules involved in brain development. We have previously shown expression levels for sulfate transporter Slc13a4 to be elevated during postnatal development, and accumulation brains +/− mice reduced, suggesting role this critical window In order understand pathways regulated by cellular sulfation within brain, we performed bulk RNA-sequencing analysis forebrain day 20 (P20)...
Summary Induced Pluripotent Stem Cells (iPSC) derived from healthy individuals are important controls for disease modeling studies. To create a resource of genetically annotated iPSCs, we reprogrammed footprint-free lines four volunteers in the Personal Genome Project Canada (PGPC). Multilineage directed differentiation efficiently produced functional cortical neurons, cardiomyocytes and hepatocytes. Pilot users further demonstrated line versatility by generating kidney organoids,...