A5101459573- Liver Disease Diagnosis and Treatment
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Ovarian cancer diagnosis and treatment
- Pediatric health and respiratory diseases
- Liver Disease and Transplantation
- Intraperitoneal and Appendiceal Malignancies
- Asthma and respiratory diseases
- Alcohol Consumption and Health Effects
- Eosinophilic Esophagitis
- Respiratory Support and Mechanisms
- Gastroesophageal reflux and treatments
- Lipid metabolism and disorders
- Diet, Metabolism, and Disease
- Helicobacter pylori-related gastroenterology studies
- Psychosocial Factors Impacting Youth
- Adipokines, Inflammation, and Metabolic Diseases
- Ovarian function and disorders
- Political Philosophy and Ethics
- Nutritional Studies and Diet
- Hospital Admissions and Outcomes
- Cognitive Science and Education Research
- Neuroscience and Neuropharmacology Research
- Game Theory and Voting Systems
- Hepatocellular Carcinoma Treatment and Prognosis
- Respiratory viral infections research
Seoul National University
2011-2025
Samsung Medical Center
2024
Seoul National University Hospital
2018
Asan Medical Center
2016
Australian Dental Association
2016
The University of Adelaide
2016
University of Ulsan
2016
Ulsan College
2016
The different clinical manifestations of gastroesophageal reflux disease (GERD) may be influenced by associated psychological factors. We evaluated the status (anxiety and depression) according to each subtype GERD.Subjects who underwent esophagogastroduodenoscopy completed a symptom questionnaire between January 2008 December 2011 were analyzed. subjects classified into following groups: erosive (ERD), non-erosive (NERD), asymptomatic esophagitis (AEE), controls. Anxiety depression assessed...
Backgrounds: Depression and anxiety disorder are frequently seen in patients with nonalcoholic fatty liver disease (NAFLD). However, the associations between mood disorders NAFLD have not been fully evaluated. In this study, we investigated relationship depression or a Korean population. Methods: We conducted retrospective cross-sectional study that included subjects who underwent abdominal ultrasonography completed symptom questionnaire for routine health check-up. was diagnosed graded...
The development of nonalcoholic fatty liver disease (NAFLD) is associated with multiple genetic and environmental factors.We performed a genome-wide association study to identify the factors related NAFLD in Korean population-based sample 1,593 subjects 2,816 controls. We replicated data another that included 744 patients 1,137 investigated single-nucleotide polymorphisms (SNPs) were NAFLD.After adjusting for age, sex body mass index, rs738409, rs12483959 rs2281135, located PNPLA3 gene,...
The Health and Prevention Enhancement (H-PEACE) study was designed to investigate the association of diagnostic imaging results, biomarkers predisease stage non-communicable diseases (NCDs), such as malignancies metabolic diseases, in an average-risk population Korea.This enrolled a large-scale retrospective cohort at Healthcare System Gangnam Center, Seoul National University Hospital, from October 2003 December 2014.The baseline follow-up information collected NCDs allows for evaluation...
Some genetic variants are associated with lung function decline and chronic obstructive pulmonary disease (COPD), but functional studies necessary to confirm causality. We investigated the susceptibility-associated or without COPD, using data from a community-based cohort (N = 8554). A genome-wide interaction study was conducted identify association between function, way relate impairment in accordance smoking status amount examined. further used linear mixed model examine time effect. found...
Progressive decline in lung function is the hallmark of chronic obstructive pulmonary disease (COPD). We aimed to assess rate forced expiratory volume 1 second (FEV1) patients from a community cohort database Korea. 5,865 subjects aged 40-69 years Ansung-Ansan I-III (2001-2006) were included this study. assessed annual FEV1 over time relation smoking status, patient sex, and presence or absence pre-bronchodilator airflow limitation using generalized additive mixed model. The mean follow-up...
A relationship between nonalcoholic fatty liver disease (NAFLD) and sarcopenia has been suggested. The aim of this study was to evaluate the association NAFLD skeletal muscle mass measured by computed tomography (CT). clinical records individuals visiting our center for a routine health check-up who underwent abdominal ultrasonography CT scanning were retrospectively reviewed. Sarcopenia diagnosed according body index (BMI)-adjusted mass, which (CT-measured (SMICT)). Of 1828 subjects (1121...
Background: Machine learning (ML) is a promising methodology for classification and prediction applications in healthcare. However, this method has not been practically established clinical data. Hyperuricemia biomarker of various chronic diseases. We aimed to predict uric acid status from basic healthcare checkup test results using several ML algorithms evaluate the performance. Methods: designed model hyperuricemia comprehensive health database by algorithms, such as discrimination...
The association between nonalcoholic fatty liver disease and lung function has not been fully examined. aim of this study was to clarify the in general population by performing cross-sectional longitudinal analysis.Participants without hepatic respiratory who underwent regular health exams including sonography spirometry with at least 3 years' follow-up were included. In analysis, baseline examined multiple regression models. analysis performed mixed linear models propensity score...
Abstract Cigarette smoke exposure is a major risk factor in chronic obstructive pulmonary disease (COPD) and its interactions with genetic variants could affect lung function. However, few gene-smoking have been reported. In this report, we evaluated the effects of on function using Korea Associated Resource (KARE) data spirometric variables—forced expiratory volume 1 s (FEV ). We found that variations FEV were different among smoking status. Thus, considered linear mixed model for...
Purpose: COPD is a leading cause of morbidity and mortality. However, few studies have used spirometry to investigate its incidence, especially in Asia. In the present study, we analyzed incidence risk factors using community cohort database Korea. Patients methods: The study included 6,517 subjects aged 40–69 years from Ansung–Ansan I–III (2001–2006). We calculated crude rate standardized corrected for Korean general population world with COPD. also determined relative risks (RRs) incident...
Abstract Recently, HLA class II loci, including HLA‐DPB1 , have been reported to be associated with interindividual variance in the hepatitis B (HB) vaccine response. In this study, we investigated significant single nucleotide polymorphisms (SNPs) for anti‐HBs antibody levels 6867 healthy Koreans using a genome‐wide association study (GWAS). GWAS, top 20 SNPs that showed ( P < 1.0 × 10 −29 ) all resided . Utilizing PCR sequencing, verified relationship of 3 most (rs1042169, rs9277355 and...
Many studies have reported an increased arterial stiffness using pulse wave velocity (PWV) in women with polycystic ovary syndrome (PCOS). However, PWV is essentially dependent on blood pressure (BP) at the time of measurement. The cardio-ankle vascular index (CAVI) a relatively new for measuring stiffness, and its conspicuous feature independency from BP aim this study was to evaluate by CAVI PCOS patients (n = 26) age-matched controls 59). measured single medical professional. mean age...
Background: Nonalcoholic fatty liver disease (NAFLD) is associated with a wide spectrum of metabolic abnormalities.This study aimed to evaluate whether NAFLD benign prostatic hyperplasia (BPH) independent other risk factors.Methods: A total 3,508 subjects who underwent prostate and hepatic ultrasonography were enrolled.NAFLD was diagnosed graded by ultrasonographic findings.BPH defined volume.Results: The prevalence BPH significantly increased according severity (P < 0.001).The multivariate...
Abstract Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD); however, more than 25% of COPD patients are non-smokers, and gene-by-smoking interactions expected to affect onset. We aimed identify the common genetic variants interacting with pack-years smoking on FEV 1 /FVC ratios in individuals normal lung function. A genome-wide interaction study (GWIS) was performed ratio ≥ 70 Korea Associated Resource cohort data, significant SNPs were validated using data from...
The inflammatory response is considered a defence mechanism against physical or infectious insults and prevalent within the central nervous system. Seizures also result in robust cascade, leading to enhanced activation of excitatory synaptic networks. Ample evidence based on animal models epilepsy has demonstrated that celecoxib, highly selective inhibitor cyclooxygenase-2, anticonvulsant effects. We aimed evaluate impact celecoxib cortical excitability electrophysiological properties brain...
Background: The neutrophil–lymphocyte ratio (NLR) is a valuable prognostic or predictive biomarker in various diseases, but the genetic factors that underlie NLR have not been studied. We attempted to investigate polymorphisms related phenotype and analyze their ability predict metabolic risks. Methods: A genome-wide association study was performed with log-transformed using an Affymetrix Axiom™ KORV1.1-96 Array. Regression models for risk status were designed identified significant...
<h3>Introduction/Background</h3> The addition of hyperthermic intraperitoneal chemotherapy (HIPEC) during interval cytoreductive surgery increases progression-free and overall survival for patients with stage III ovarian cancer in two randomized controlled trials (OV-HIPEC-01 KOV-HIPEC-01). aim this trial is to identify the benefit HIPEC & IV era maintenance therapy bevacizumab and/or PARP inhibitor. <h3>Methodology</h3> Ovarian will be at time achieving complete cytoreduction or no more...
Abstract Some genetic variants are associated with chronic obstructive pulmonary disease (COPD), but susceptibility for lung function decline has not been studied in the general population. We investigated susceptibility-associated or without COPD, using data from a community-based cohort. A genome-wide interaction study was conducted to identify association between and function, way relate impairment accordance smoking status amount examined. further used linear mixed model examine time...
INTRODUCTION: The male-predominant sex difference through the spectrum of erosive esophagitis to Barrett's esophagus is widely known. We conducted a genome-wide association study (GWAS) stratified by for identifying factors that can predict endoscopically diagnosed esophagitis. METHODS: Erosive was endoscopy and assessed severity. identified genetic associated with accounted differences in cohort 4,242 participants via GWAS. After quality control imputation, associations were investigated...
Results: Among 26 of these patients, 22 (87%) took other sleeping pills.Mean duration taking PRM among 24 patients who were followed was 28.0 ± 13.0 days.At study endpoint, satisfaction rate to 71% (n=17) and daytime sleepiness (n=2), headache (n=1), dizziness (n=1) reported as TEAE.Among 20 also prescribed pills followed-up, 40% (n=8) could reduce their dosage more than 50%. Conclusion:We observed a when we it dissatisfied with sleep even after schedule set.TEAE not prevalent simultaneously...