A5008725478- Cerebrovascular and Carotid Artery Diseases
- Intracranial Aneurysms: Treatment and Complications
- Acute Ischemic Stroke Management
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Ultrasound and Hyperthermia Applications
- Vascular Malformations Diagnosis and Treatment
- Ultrasound Imaging and Elastography
- Venous Thromboembolism Diagnosis and Management
- Alzheimer's disease research and treatments
- Moyamoya disease diagnosis and treatment
- Advanced MRI Techniques and Applications
- Traumatic Brain Injury and Neurovascular Disturbances
- Aortic aneurysm repair treatments
- Advanced Fluorescence Microscopy Techniques
- Intracerebral and Subarachnoid Hemorrhage Research
- Cholinesterase and Neurodegenerative Diseases
- Cerebral Venous Sinus Thrombosis
- Non-Invasive Vital Sign Monitoring
- Neurosurgical Procedures and Complications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Peripheral Artery Disease Management
- Dementia and Cognitive Impairment Research
- Vascular Procedures and Complications
- Stroke Rehabilitation and Recovery
University of Vermont Medical Center
2020-2024
Centre Hospitalier Métropole Savoie
2012-2024
University of Vermont
2022-2024
University of Cincinnati
2023
University of Cincinnati Medical Center
2023
Massachusetts General Hospital
2008-2022
Harvard University
2005-2020
American Headache Society
2020
New York Proton Center
2020
Athinoula A. Martinos Center for Biomedical Imaging
2009-2012
Amyloid-β (Aβ) deposits have been identified as key players in the progression of Alzheimer's disease (AD). Recent evidence indicates that probably precede and induce neuronal atrophy. Therefore, methods enable monitoring pathology before clinical symptoms are observed would be beneficial for early AD detection. Here, we report design, synthesis, testing a curcumin-derivatized near-infrared (NIR) probe, CRANAD-2. Upon interacting with Aβ aggregates, CRANAD-2 undergoes range changes, which...
Objective: To determine the correspondence between uptake of Pittsburgh Compound B (PiB) in life and measures -amyloid (A) postmortem tissue analysis.Patient: A 76-year-old man with a clinical diagnosis dementia Lewy bodies underwent fluorodeoxyglucose 18 F PiB positron emission tomographic brain scans.Imaging revealed marked region specific binding abnormal uptake.Intervention: Autopsy was performed 3 months after scan.Results: confirmed diagnosis; addition, there severe cerebral amyloid...
Object The goal of this study was to explore the feasibility using low-frequency magnetic resonance (MR) image–guided focused ultrasound as a noninvasive method for temporary disruption blood–brain barrier (BBB) at targeted locations. Methods Rabbits were placed inside clinical 1.5-tesla MR imaging unit, and sites in their brains 20-second burst sonications (frequency 260 kHz). peak pressure amplitude during varied between 0.1 0.9 MPa. Each sonication performed after an intravenous injection...
Alzheimer's disease is a neurodegenerative disorder typified by the accumulation of small protein, beta-amyloid, which aggregates and primary component amyloid plaques. Many new therapeutic diagnostic agents for reducing plaques have limited efficacy in vivo because poor transport across blood-brain barrier. Here we demonstrate that low-intensity focused ultrasound with microbubble contrast agent may be used to transiently disrupt barrier, allowing non-invasive, localized delivery imaging...
Ultrasound (US) enhanced with microbubble contrast agents may transiently disrupt the blood-brain barrier (BBB) minimal damage, providing a technique for noninvasive, localized drug-delivery deep within brain. The mechanism and temporal profile of disruption are not understood, owing to limitations imaging modalities used previously. In this study, we monitored US-induced BBB multiphoton microscopy, high-resolution spatial information about permeabilization immediate effects US exposure....
Abstract Imidacloprid is a new insecticide from the family of neonicotinoids, which interact with insect nicotinic acetylcholine receptor. The effects imidacloprid at dose that does not affect sensory or motor functions are studied on non‐associative learning abilities in honeybee. behavioral procedure habituation proboscis extension reflex (PER). topically applied thorax (1 μl) doses 5, 10, and 20 ng/bee induces an increase gustatory threshold defined as lowest concentration sucrose...
We describe the application of a time domain diffuse fluorescence tomography system for whole body small animal imaging. The key features are use point excitation in free space using ultrashort laser pulses and noncontact detection gated, intensified charge-coupled device (CCD) camera. Mouse shaped epoxy phantoms, with embedded fluorescent inclusions, were used to verify performance recently developed asymptotic lifetime-based algorithm. algorithm is based on multiexponential analysis decay...
A general linear model for time domain (TD) fluorescence tomography is presented that allows a lifetime-based analysis of the entire temporal response from turbid medium. Simulations are used to show TD optimally performed using two complementary approaches: direct few points near peak response, which provides superior resolution; and an asymptotic multi-exponential based decay portion accurate localization yield distributions various lifetime components present in imaging These results...
We compare frequency-and time-domain formulations of deep-tissue fluorescence imaging turbid media. Simulations are used to show that tomography, implemented via the asymptotic lifetime-based approach, offers a significantly better separability multiple lifetime targets than frequency-domain approach. also demonstrate experimentally, using complex-shaped phantoms, advantages approach over Fourier-based for analyzing data.
Near-infrared ͑NIR͒ fluorescence tomography of multiple fluorophores has previously been limited by the bandwidth NIR spectral regime and broad emission spectra most fluorophores.We describe in vivo three spectrally overlapping using lifetime-based separation.Timedomain images are acquired a voltage-gated, intensified chargecoupled device ͑CCD͒ free-space transmission geometry with 750 nm Ti:sapphire laser excitation.Lifetime components fit from asymptotic portion decay curve reconstructed...
Triage of posterior circulation stroke from emergent large-vessel occlusion (pc-ELVO) is challenging owing to the stuttering clinical course and potential for rapid decline. Growing data support use mechanical thrombectomy in pc-ELVO, but there are limited addressing imaging criteria patient selection. We present our triage algorithm used select patients endovascular therapy (EVT) setting pc-ELVOS. a consecutive retrospective database 2004 2016 describe practice patterns prognostic factors...
BACKGROUND AND OBJECTIVES: Dual antiplatelet therapy (DAPT) is necessary to minimize the risk of periprocedural thromboembolic complications associated with aneurysm embolization using pipeline device (PED). We aimed assess impact platelet function testing (PFT) on reducing PED flow diversion in patients receiving aspirin and clopidogrel. METHODS: Patients unruptured intracranial aneurysms requiring were identified from 13 centers for retrospective evaluation. Clinical variables including...
We show that fluorescence lifetime is a powerful contrast mechanism can enhance the whole-body imaging of fluorescent proteins (FPs), in presence background tissue autofluorescence (AF). The nonexponential AF decay characterized from time-domain (TD) measurements on multiple nude mice and separated FP using linear fit to priori basis functions. illustrate this approach an orthotopic mouse tumor model breast adenocarcinoma. also report four commonly used FPs distinct lifetimes, indicating...
OBJECTIVE Several grading systems for procedural risk in the endovascular treatment of brain arteriovenous malformations (AVMs) have been proposed, including Buffalo, Puerto Rico, and AVM embocure scoring systems. The authors sought to validate these an independent patient cohort compare each system established Spetzler-Martin (SM) scale. METHODS One hundred four consecutive patients underwent adjunctive embolization AVMs between 2002 2016 with goal reducing surgical or hemorrhagic before...
Abstract We hypothesized a difference in the spatial distribution of intracranial vessel wall enhancement between CNS vasculitis and risk factors for atherosclerotic disease (ICAD). Fifty-five MR imaging (VWI) exams were included this retrospective observational study. Intracranial arteries evaluated by branching pattern (e.g., primary, secondary, tertiary segments). Demographic laboratory data as well ICAD factors, including diagnosis hypertension, collected. A primary angiitis (PACNS) was...
Introduction The LVIS Blue is an FDA-approved stent with 28% metallic coverage that indicated for use in conjunction coil embolization the treatment of intracranial aneurysms. Given a porosity similar to approved flow diverters and higher than currently available stents, we sought evaluate effectiveness this device Methods We performed observational single-center study initial occlusion at 6-month follow-up patients treated our institution using modified Raymond–Roy classification (mRRC),...
ABSTRACT BACKGROUND AND PURPOSE We hypothesized that vessel wall MR imaging (VWI) with 3D‐time‐of‐flight magnetic resonance (3D‐TOF‐MRA) together increases the ability to detect abnormal intracranial segments compared 3D‐TOF‐MRA alone. METHODS Ninety‐three consecutive subjects a clinical history of suspected vasculopathy imaged both VWI and 3D‐TOF‐MRAs were retrospectively reviewed. The reviewed by two independent neuroradiologists classifying arterial as normal or based on caliber changes....