A5015521335- Metabolomics and Mass Spectrometry Studies
- Liver Disease Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Veterinary Equine Medical Research
- Gut microbiota and health
- Exercise and Physiological Responses
- Diet and metabolism studies
- Adipose Tissue and Metabolism
- Poisoning and overdose treatments
- RNA Interference and Gene Delivery
- Oral Health Pathology and Treatment
- Bone Tissue Engineering Materials
- Oral microbiology and periodontitis research
- Advanced Drug Delivery Systems
- Seed and Plant Biochemistry
- Spondyloarthritis Studies and Treatments
- Probiotics and Fermented Foods
- Genomics, phytochemicals, and oxidative stress
- Forensic Entomology and Diptera Studies
- Herpesvirus Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Cardiac Arrest and Resuscitation
- Advances in Cucurbitaceae Research
- Advancements in Transdermal Drug Delivery
- Signaling Pathways in Disease
Wroclaw University of Environmental and Life Sciences
2022-2024
University of Basrah
2024
Wrocław University of Science and Technology
2019-2022
AGH University of Krakow
2019-2022
Chronic periodontitis is an inflammatory disease of tooth-supporting tissues associated with Porphyromonas gingivalis. Expansion and invasion this bacterium into the periodontium changes in metabolome oral cavity. Materials Methods: Metabolomics analysis mouth washout tongue swab samples based on proton nuclear magnetic resonance (<sup>1</sup>H-NMR) method was employed to determine metabolic status cavity chronic periodontal disease. Results: Mouth extracts contained a total 23 metabolites...
Non-alcoholic fatty liver disease (NAFLD) is associated with dysfunction of the intestinal microbiota and its metabolites. We aimed to assess whether replacing bread high-fiber buns beneficially changes metabolome in NAFLD patients. This study involved 27 adult patients validated by FibroScan® (CAP ≥ 234 dB/m). Patients were asked replace their existing for two meals buns. In this way, ate rolls every day 2 months. The following parameters analysed (at beginning after months): anthropometric...
Endometriosis is a gynecological disease defined by the presence of endometrial tissue outside uterus. To date, effective treatment this still based on invasive surgery or laparoscopy. Chelidonium majus L. (Papaveraceae) belongs to medicinal, latex-bearing plants. Extracts from plant are rich source pharmacologically active agents. Protoberberine compounds derived C. possess anticancer and antiproliferative activities. In present study rat model endometriosis, we investigated influence...
Equine metabolic syndrome (EMS) is a steadily growing endocrine disorder representing real challenge in veterinary practice. As multifactorial condition, EMS characterized by three main abnormalities including insulin resistance, increased adiposity or obesity and hoof laminitis. Adipose tissue dysfunction recognized as core pathophysiological determinant of EMS, it strongly participates to lipotoxicity systemic metaflammation, both which have been closely linked the development generalized...
Equine metabolic syndrome (EMS) is a significant global health concern in veterinary medicine. There increasing interest utilizing molecular agents to modulate hepatocyte function for potential clinical applications. Recent studies have shown promising results inhibiting protein tyrosine phosphatase (PTP1B) maintain cell various models. In this study, we investigated the effects of inhibitor Trodusquemine (MSI-1436) on equine hepatic progenitor cells (HPCs) under lipotoxic conditions. We...
Abstract Background Equine metabolic syndrome (EMS), which encompasses insulin resistance, low-grade inflammation and predisposition to laminitis is a critical endocrine disorder among the most prevalent conditions affecting horses from different breeds. According recent research, low human sex hormone-binding globulin (SHBG) serum levels correlate with an increased risk of obesity, resistance diabetes, may contribute overall dysregulations. This study aimed test whether exogenous SHBG could...
We compared fecal samples from responders and non-responders to administration of Lactobacillus reuteri DSM 17938. Data for this post hoc analysis were collected an RCT assessing the efficacy L. management acute gastroenteritis. Responders defined as subjects with diarrhea lasting no longer than 48 h. 44 children (17 27 non-responders) analyzed. There differences in clinical characteristics gut colonization between both groups. In responder group, there significantly lower levels five...
The purpose of this study was to describe the use PLDLA/TPU matrix enriched with cyclosporine A (CsA) as a therapeutic platform in horses immune-mediated keratitis (IMMK) an vitro evaluation CsA release and degradation blend well determination safety efficacy that used animal model. kinetics from matrices constructed thermoplastic polyurethane (TPU) polymer copolymer L-lactide DL-lactide (PLDLA) (80:20) TPU (10%) PLDL (90%) were studied. Moreover, we STF (Simulated Tear Fluid) at 37 °C...
Rheumatoid arthritis (RA), ankylosing spondylitis (AS), and psoriatic (PsA) are comprehensive immunological disorders. The treatment of these disorders is limited to ameliorating the symptoms improving quality life patients. In this study, serum samples from RA, AS, PsA patients were analyzed with metabolomic tools employing 1H NMR method in combination univariate multivariate analyses. results obtained study showed that changes metabolites highest for AS > RA PsA. demonstrated time until...
Six alkaloid compounds were isolated (the discovery of a natural drug, which is combination the six compounds). Alkaloids viz., 1,3,5-Triazine-2-carboxylic acid, 4-amino-6-methyl; 1,2,4-Triazino[5,6-E][1,2,4]-triazine-3,6-dione, hexahydro; 2-(4,5-Dihydro-3-methyl-5-oxo-1-phenyl-4-pyrazole)-5-nitrobenzoic acid; 4-metyl-3,4-dihydro-[1,2,3] trizolo [4,5-d] pyrimidine-5,7-dione; Propanoic acid-3-(perhydro-2,5-dioxo-imidazol imidazole-1-yl) and 1,2,3-Triazolo[4,5-f] benzotriazole-...
Equine metabolic syndrome (EMS) is a major health threat in veterinary endocrinology medicine worldwide, and there growing interest utilizing molecular agents for modulation of hepatocyte function potential clinical applications with recent studies showing promising results the inhibition PTP1B on adipose-derived stromal cells. In this study, we investigated effects MSI-1436 equine hepatic progenitor cells (HPCs) terms their proliferative activity, glucose uptake, mitochondrial morphogenesis...
Abstract There is a clear difference between severe brain damage and death. However, in clinical practice, the differentiation of these states can be challenging. Currently, there are no laboratory tools that facilitate death diagnosis. The aim our study was to evaluate utility serum metabolomic analysis differentiating coma patients (CP) from individuals with (BD). Serum samples were collected 23 adult established diagnosis 24 Glasgow Coma Scale 3 or 4, other symptoms for at least 7 days...
Abstract There is a clear difference between severe brain damage and death. However, in clinical practice, the differentiation of these states can be challenging. Currently, there are no laboratory tools that facilitate death diagnosis. The aim our study was to evaluate utility serum metabolomic analysis differentiating coma patients (CP) from individuals with (BD). Serum samples were collected 23 adult established diagnosis 24 Glasgow Coma Scale 3 or 4, other symptoms for at least 7 days...