A5089597024- Parkinson's Disease Mechanisms and Treatments
- Epigenetics and DNA Methylation
- Neuropeptides and Animal Physiology
- Amyotrophic Lateral Sclerosis Research
- Diabetes Treatment and Management
- Enterobacteriaceae and Cronobacter Research
- Family and Disability Support Research
- Genetic Neurodegenerative Diseases
- Escherichia coli research studies
- Pharmacology and Obesity Treatment
- Pancreatic function and diabetes
- Viral gastroenteritis research and epidemiology
Deleted Institution
2023
Tongji University
2022
Jiangsu Normal University
2020-2022
Xinjiang Agricultural University
2021
Abstract Background Aging is the strongest risk factor for Parkinson's disease (PD), which a clinically heterogeneous movement disorder with highly variable age at onset. DNA methylation (DNAm age) an epigenetic clock that could reflect biological aging. Objectives The aim was to evaluate whether PD onset associated DNAm‐age acceleration (difference between DNAm and chronological age). Methods We used genome‐wide Infinium MethylationEPIC array assess in discovery ( n = 96) replication 182)...
Diabetes is characterized by pancreas dysfunction and commonly associated with obesity. Hypoglycemic agents capable of improving β-cell function reducing body weight therefore are gaining increasing interest. Though glucagon-like peptide 1 receptor (GLP-1R)/cholecystokinin 2 (CCK-2R) dual agonist ZP3022 potently increases mass improves glycemic control in diabetic db/db mice, the vivo half-life (t1/2) short, its activity limited. Here, we report discovery a series novel GLP-1R/CCK-2R...
Non-O157 Shiga toxin (stx)-producing Escherichia coli (STEC) is recognized as an important human diarrheal pathogen. Cattle are the principal reservoirs of STEC, although other animals can be carriers. Humans mainly infected by consuming contaminated drinking water or food. This study aimed to evaluate virulence potential isolated bovine non-O157 STEC humans in Xinjiang. During 2015-2017, 978 rectal swab samples collected from cattle 5 farms were screened for presence toxin-encoding genes...
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Abstract Parkinson’s disease is a clinically and genetically heterogeneous movement disorder with highly variable age-at-onset. DNA methylation (DNAm) age an epigenetic clock that could reflect biological aging. Studies of DNAm-age acceleration (difference between chronological age) are pertinent to neurodegenerative diseases (e.g., disease), for which aging the strongest risk-factor. We assessed in idiopathic (n=96) longitudinal LRRK2 cohort at four time-points over 3-year period (n=220),...