A5072762090- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Organometallic Complex Synthesis and Catalysis
- Metal complexes synthesis and properties
- Total Knee Arthroplasty Outcomes
- Long-Term Effects of COVID-19
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Crystallography and molecular interactions
- Ferrocene Chemistry and Applications
- SARS-CoV-2 and COVID-19 Research
- SARS-CoV-2 detection and testing
- Dermatologic Treatments and Research
- Hydrogen's biological and therapeutic effects
- Dental Research and COVID-19
- Mosquito-borne diseases and control
- COVID-19 Clinical Research Studies
- Synthesis and Characterization of Heterocyclic Compounds
- Asymmetric Hydrogenation and Catalysis
- Rheumatoid Arthritis Research and Therapies
- Organometallic Compounds Synthesis and Characterization
- Orthopedic Infections and Treatments
- Brain Metastases and Treatment
- Cancer-related cognitive impairment studies
- Nail Diseases and Treatments
Universidad de Colima
2021-2023
Instituto Politécnico Nacional
2004-2016
Center for Research and Advanced Studies of the National Polytechnic Institute
2004-2016
Risk factors for developing long COVID are not clearly established. The present study was designed to determine if any sign, symptom, or treatment of the acute phase, personal characteristics patient, is associated with development COVID.A cohort carried out, randomly selecting symptomatic COVID-19 patients and vaccinated. severity illness assessed through number compatible symptoms, hospitalizations, symptom score using a 10-point visual analog scale.After multivariate analysis, ≥8 (RR 2.0,...
Coronavirus disease 2019 (COVID‑19) is currently the major public health problem worldwide. Neutral electrolyzed saline solution that contains reactive chlorine and oxygen species may be an effective therapeutic. In present study, treatment efficacy of intravenous and/or nebulized neutral combined with usual medical care vs. alone was evaluated in ambulatory patients COVID‑19. A prospective, 2‑arm, parallel‑group, randomized, open‑label, multi‑center, phase I‑II clinical trial including 214...
Mefenamic acid is a non‑steroidal anti‑inflammatory drug exhibiting wide range of anti‑inflammatory, antipyretic, analgesic and probable antiviral activities. The present study evaluated the efficacy treatment with mefenamic combined standard medical care vs. plus placebo in ambulatory patients coronavirus disease 2019 (COVID‑19; nasal/oropharyngeal swabs reverse transcription‑PCR test results positive for severe acute respiratory syndrome 2). phase II prospective, two‑arm, parallel‑group,...
Arthralgia is a potentially incapacitating condition and persistent symptom in chronic or acute episodes of Chikungunya fever caused by infection with the virus (CHIKV). To best our knowledge, there are no reports on risk factors associated intensity arthralgias typical disease. Although number studies have reported development stage disease, smoking habits not been analyzed. Smoking an interesting factor to consider since it main environmental for rheumatoid arthritis (RA), similar disease...
Abstract Reactions between CS 2 and the exocyclic amino groups of 2‐aminobenzothiazoles gave series molecules bearing thiourea, isothiourea, dithiocarbamate, dithiocarboimine, dimethyldithiocarbamate, methyldithiocarbamate, S ‐CH 3 O ‐alkyl thiocarbamic ester, guanidine groups. Preferred tautomers conformers were determined. Most compounds present coordinative bonds endocyclic sulfur atom, which behaves as a Lewis acid, oxygen, nitrogen, acting bases. A new...
Background and Objectives: Gentamicin (GM) is a nephrotoxic aminoglycoside. Neutral electrolyzed saline (SES) compound with anti-inflammatory, antioxidant, immunomodulatory properties. The objective of the present study was to evaluate whether kidney damage by GM can be prevented and/or reversed through administration SES. Materials Methods: carried out as prospective, single-blind, five-arm, parallel-group, randomized, preclinical trial. nephrotoxicity model established in male BALB/c mice...
Background: Coronavirus disease (COVID-19) is currently the main public health problem worldwide. The administration of neutral electrolyzed saline, a solution that contains reactive species chlorine and oxygen (ROS), may be an effective therapeutic alternative due to its immunomodulating characteristics, in systemic inflammation control, as well immune response improvement, promoting control viral infection. present study evaluated efficacy treatment with intravenous and/or nebulized saline...
The worldwide efforts that healthcare professionals are making in the COVID‑19 pandemic is well known, and high risk of illness death front‑line staff experience on a daily basis reality, despite well‑defined protocols for use personal protective equipment. In addition, it known vaccination still faraway to be achieved new variants emerging, thus additional measures must explored. A prospective open‑label randomized controlled clinical trial was performed medical from Dr. Enrique Cabrera...
A promising novel cell-free bioactive formulation for articular cartilage regeneration, called BIOF2, has recently been tested in pre-clinical trials. The aim of the present study was to evaluate efficacy and safety BIOF2 intra-articular application patients with severe osteoarthritis knee.A prospective, randomized, 3-arm, parallel group clinical trial conducted. It included 24 knee (WOMAC score 65.9 ± 17). Before they entered study, all were under control through standard treatment...
The metathesis reaction of [(η4-COD)Ir(μ-Cl)]2 (4) with two equivalents the sodium thiapentadienide (1Na) or potassium sulfinylpentadienide salt (2K) led to formation corresponding dimers [(η4-COD)Ir(μ2-1-2,5-η-CH2CHCHCHS)]2 (5) and [(η4-COD)Ir(μ2-1-2,5-η-CH2CHCHCHSO)]2 (9). single-crystal analysis 5 9 reveals presence thiapentadienyl sulfinylpentadienyl ligands bridging through sulfur atoms terminal double bonds both iridium centers. Treatment PMe3 produces...
ABSTRACT Objectives Helicobacter pylori gastric infection strongly correlates with diseases such as chronic gastritis, functional dyspepsia, and complications peptic ulcers cancer. In developing countries, systemic therapies are not usually successful due to elevated antibiotic resistance. Additionally, oral H. periodontal disease correlate treatment failures. This study aimed explore the effect of an integral therapy, comprising hygiene concomitant treatment, increase eradication...
Reactions of the tetranuclear (Cp*RuCl)4 (1) with corresponding butadienesulfinate salts Li[SO2CH═CR′CH═CHR] [R = R′ H, (2a); R Me, (2b); (2c)] in THF result formation tetrameric [Cp*Ru(1,2,5-η-SO2CH═CR′CH═CHR)LiCl]4 (3); (4); (5)] complexes. Compound 5 has been isolated two pseudo-polymorphic crystal forms as space group P4̅21c and 5·3THF, where there are three molecules solvated per tetramer, I4̅. Both tetramers occupied a crystallographic 4-fold-roto inversion axis. In both structures...
The reaction of dinuclear (Cp*RhCl2)2 (1) with the lithium butadienesulfinate salt Li[SO2CH═CHCH═CH2] (2-Li) in THF results formation dimeric [Cp*Rh(Cl)2(5-η-SO2CH═CRCH═CHR)(Li)(THF)]2 (3) 82% yield, while an excess potassium butadienesulfinate, K[SO2CH═CHCH═CH2] (2-K), affords mononuclear rhodium ion pair [Cp*RhCl(5-η-SO2CH═CHCH═CH2)(5-η-S(O2−K+)CH═CHCH═CH2)] (5-K) 90% yield. Compound 5-K reacts AgBF4 to give neutral compound [Cp*Rh(1,2,5-η-SO2CH═CHCH═CH2)(5-η-SO2CH═CHCH═CH2)] (6) 67%...
Dengue virus (DENV) is currently considered as one of the most important mosquito-borne viral pathogens affecting humans. Genetic variations in viruses are likely to be a condition for more effective evasion immune system and resulting severe clinical consequences. The DENV‑1 NS5 gene was sequenced establish whether during an epidemic burst there were genetic any variant associated (through case‑control design) with behavior. A total 31 patients positive enrolled. Among nucleotide...
The molecule (η5-Me2Pdl)Mn(CO)3 (η5-Me2Pdl = 2,4-dimethyl-η5-pentadienyl) has been prepared by a new method and used as starting material to prepare the molecules (η5-Me2Pdl)Mn(CO)n(PMe3)3–n (n 2, 1) phosphine substitution for carbonyls. first carbonyl is achieved thermally in refluxing cyclohexane, second requires photolysis. At room temperature benzene associative intermediate (η3-Me2Pdl)Mn(CO)3(PMe3) that precedes initial loss of observed. Single-crystal structures are reported all...
Osteoarthritis (OA) is a chronic disorder of synovial joints, in which there progressive softening and disintegration the articular cartilage. OA most common form arthritis, primary cause disability impaired quality life elderly. Despite considerable medical necessity, no treatment has yet been proven to act as disease‑modifying agent that may halt or reverse structural progression OA. The replacement joint with prosthesis appears be best option advanced stages disease. A formulation (BIOF2)...
Rheumatoid arthritis is globally present in about 1% of the population. This autoinflammatory disease modifies connective tissue, causing pain and inflammation joints. Over time, it causes loss joint cartilage bone mass, decreasing patient's quality life. Treatment options now available either give symptomatic alleviation or alter process. Nonetheless, adherence to chronic treatment typically limited due adverse effects. As a result, new therapy approaches, such as systemic administration...
Osteoarthritis (OA) is a major public health problem characterized by joint pain, fatigue, functional limitation and decreased quality of life the patient, which results in increased use healthcare services high economical costs. A promising novel bioactive cell-free formulation (BIOF2) for cartilage regeneration has recently been tested pre-clinical clinical trials, demonstrated success rate similar to that total arthroplasty treatment severe knee OA. The present study evaluated efficacy...
Neutral Electrolyzed Water (NEW) is a type of electrolyzed oxidizing water that exhibits health-promoting properties in humans, as evidenced by its positive effects on wound repair, encompassing mild to severe injuries, modulation both local and systemic inflammatory processes and, more recently, the prevention control infections symptoms associated with COVID-19. Concerning potential cancer treatment, there have been no prior direct investigations into cells. In this study, we examined...
Burn injuries impose challenges such as infection risk, pain management, fluid loss, electrolyte imbalance and psychological emotional impact, on healthcare professionals, requiring effective treatments to enhance wound healing. The present study evaluated the efficacy superoxidized electrolyzed solution (SES), with low (SES‑low) or high (SES‑high) concentrations of active species, alone in combination a formulation gel (G), comparison commonly prescribed for burn injury, including...