A5045600738- SARS-CoV-2 and COVID-19 Research
- Osteoarthritis Treatment and Mechanisms
- Dental Research and COVID-19
- Total Knee Arthroplasty Outcomes
- Dermatologic Treatments and Research
- Knee injuries and reconstruction techniques
- Long-Term Effects of COVID-19
- Health and Medical Education
- SARS-CoV-2 detection and testing
- Histone Deacetylase Inhibitors Research
- Hydrogen's biological and therapeutic effects
- Acute Kidney Injury Research
- Tannin, Tannase and Anticancer Activities
- Liver Disease and Transplantation
- Legionella and Acanthamoeba research
- Amoebic Infections and Treatments
- Rheumatoid Arthritis Research and Therapies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Tea Polyphenols and Effects
- Toxoplasma gondii Research Studies
- Intensive Care Unit Cognitive Disorders
- Liver physiology and pathology
- Computational Drug Discovery Methods
- Liver Disease Diagnosis and Treatment
- Parasitic Infections and Diagnostics
Universidad de Colima
2018-2024
Mexican Social Security Institute
2024
Universidad Autónoma Metropolitana
2021
Instituto Politécnico Nacional
2017
Center for Research and Advanced Studies of the National Polytechnic Institute
2017
COVID-19 vaccines primarily prevent severe illnesses or hospitalization, but there is limited data on their impact during hospitalization for seriously ill patients. In a Mexican cohort with high mortality, study assessed vaccination's effects. From 2021 to 2022, 462 patients 4455 hospital days were analyzed. The generalized multivariate linear mixed model (GENLINMIXED) binary logistic regression link, survival analysis and ROC curves used identify risk factors death. results showed that the...
Coronavirus disease 2019 (COVID‑19) is currently the major public health problem worldwide. Neutral electrolyzed saline solution that contains reactive chlorine and oxygen species may be an effective therapeutic. In present study, treatment efficacy of intravenous and/or nebulized neutral combined with usual medical care vs. alone was evaluated in ambulatory patients COVID‑19. A prospective, 2‑arm, parallel‑group, randomized, open‑label, multi‑center, phase I‑II clinical trial including 214...
(SO) is one of the most widely used plants in traditional medicine worldwide. In present study, effect an ethanolic extract
Background and Objectives: Gentamicin (GM) is a nephrotoxic aminoglycoside. Neutral electrolyzed saline (SES) compound with anti-inflammatory, antioxidant, immunomodulatory properties. The objective of the present study was to evaluate whether kidney damage by GM can be prevented and/or reversed through administration SES. Materials Methods: carried out as prospective, single-blind, five-arm, parallel-group, randomized, preclinical trial. nephrotoxicity model established in male BALB/c mice...
Background: Coronavirus disease (COVID-19) is currently the main public health problem worldwide. The administration of neutral electrolyzed saline, a solution that contains reactive species chlorine and oxygen (ROS), may be an effective therapeutic alternative due to its immunomodulating characteristics, in systemic inflammation control, as well immune response improvement, promoting control viral infection. present study evaluated efficacy treatment with intravenous and/or nebulized saline...
The worldwide efforts that healthcare professionals are making in the COVID‑19 pandemic is well known, and high risk of illness death front‑line staff experience on a daily basis reality, despite well‑defined protocols for use personal protective equipment. In addition, it known vaccination still faraway to be achieved new variants emerging, thus additional measures must explored. A prospective open‑label randomized controlled clinical trial was performed medical from Dr. Enrique Cabrera...
A promising novel cell-free bioactive formulation for articular cartilage regeneration, called BIOF2, has recently been tested in pre-clinical trials. The aim of the present study was to evaluate efficacy and safety BIOF2 intra-articular application patients with severe osteoarthritis knee.A prospective, randomized, 3-arm, parallel group clinical trial conducted. It included 24 knee (WOMAC score 65.9 ± 17). Before they entered study, all were under control through standard treatment...
Vitamin D3 or calcitriol (VitD3) has been shown to have anticancer and anti-inflammatory activity in vitro models clinical studies. However, its effect on HPV-16-related cancer sparsely explored. In this study, we aimed determine whether monotherapy combination therapy with cisplatin (CP) reduces tumor growth affects survival systemic inflammation. Treatments were administered C57BL/6 mice tumors (TC-1 cells) as follows: (1) placebo (100 µL vehicle, olive oil, orally daily); (2) VitD3 (3.75...
Metabolic syndrome (MS) has been associated with testicular damage. Nonalcoholic fatty liver disease (NAFLD) is a multisystemic that affects different organs, but its effect on the testes unknown. A study analyzing germ cell involvement BALB/c mice was carried out. parallel comparative conducted investigated alterations in germinal epithelium of male humans died from an unrelated acute event. The complete medical histories and histologic samples thoracic aorta, tissue, tissue deceased...
Osteoarthritis (OA) is a chronic disorder of synovial joints, in which there progressive softening and disintegration the articular cartilage. OA most common form arthritis, primary cause disability impaired quality life elderly. Despite considerable medical necessity, no treatment has yet been proven to act as disease‑modifying agent that may halt or reverse structural progression OA. The replacement joint with prosthesis appears be best option advanced stages disease. A formulation (BIOF2)...
Rheumatoid arthritis is globally present in about 1% of the population. This autoinflammatory disease modifies connective tissue, causing pain and inflammation joints. Over time, it causes loss joint cartilage bone mass, decreasing patient's quality life. Treatment options now available either give symptomatic alleviation or alter process. Nonetheless, adherence to chronic treatment typically limited due adverse effects. As a result, new therapy approaches, such as systemic administration...
Osteoarthritis (OA) is a major public health problem characterized by joint pain, fatigue, functional limitation and decreased quality of life the patient, which results in increased use healthcare services high economical costs. A promising novel bioactive cell-free formulation (BIOF2) for cartilage regeneration has recently been tested pre-clinical clinical trials, demonstrated success rate similar to that total arthroplasty treatment severe knee OA. The present study evaluated efficacy...
Neutral Electrolyzed Water (NEW) is a type of electrolyzed oxidizing water that exhibits health-promoting properties in humans, as evidenced by its positive effects on wound repair, encompassing mild to severe injuries, modulation both local and systemic inflammatory processes and, more recently, the prevention control infections symptoms associated with COVID-19. Concerning potential cancer treatment, there have been no prior direct investigations into cells. In this study, we examined...
Burn injuries impose challenges such as infection risk, pain management, fluid loss, electrolyte imbalance and psychological emotional impact, on healthcare professionals, requiring effective treatments to enhance wound healing. The present study evaluated the efficacy superoxidized electrolyzed solution (SES), with low (SES‑low) or high (SES‑high) concentrations of active species, alone in combination a formulation gel (G), comparison commonly prescribed for burn injury, including...
Breast cancer (BC) is the most common and main cause of mortality due to in women around World. Histone deacetylase 6 (HDAC6) a promising target for treatment BC. In present study, series novel 3‑carboxy‑coumarin sulfonamides, analogs belinostat, targeting HDAC6 were designed synthesized. The compounds synthesized purified through open‑column chromatography. Characterization was performed using spectroscopic techniques, including <sup>1</sup>H <sup>13</sup>C NMR, homonuclear heteronuclear...
Background/Objectives: Averrhoa carambola, or star fruit, is a shrub known for its medicinal properties, especially due to bioactive metabolites identified in roots and fruit with anti-cancer activity. However, the biological effects of leaves remain unexplored. This study aimed assess ethanolic extract from A. carambola on triple-negative breast cancer (TNBC), an aggressive subtype lacking specific therapy. Methods: Phytochemical analysis HPLC profile additional cell line evaluation...
Las lesiones por loxoscelismo cutáneo pueden complicarse con infecciones concomitantes debido a que el diagnóstico es presuntivo y no existe un esquema de tratamiento específico.
Abstract Background: The COVID-19 pandemic, caused by the SARS-COV-2 virus, has destabilized society all around world and is predicted to take a long time be overcome. worldwide efforts that healthcare professionals are making well known, high risk of illness death front-line staff experience on daily basis reality as well. Despite well-defined protocols for use personal protective equipment, many nurses doctors still getting sick dying. It known vaccination faraway achieved new variants...
RESUMEN.Introducción: las mascarillas de ventilación mecánica no invasiva son insumos reutilizables alta demanda en los servicios terapia respiratoria.Determinar si pueden ser desinfectadas exitosamente podría ayudar a optimizar recursos.Las soluciones electrolizadas superoxidación pH neutro desinfectantes alto nivel efectivas e inocuas utilizadas el ámbito hospitalario.Objetivo: evaluar la efectividad una solución electrolizada neutra para eliminar carga bacteriana y sus efectos sobre...